Cardiorespiratory findings in sudden unexplained/unexpected death in epilepsy (SUDEP)

Stöllberger, Claudia; Finsterer, Josef

doi:10.1016/j.eplepsyres.2004.03.008

Cited by 199 publications

(186 citation statements)

References 75 publications

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“…Following this reasoning, postmortem examinations in people dying of SUDEP have found hearts that are dilated and heavier than expected 16,29,31,32 and pulmonary edema in approximately 50-86% of cases 16,26,29,32,33 . Furthermore, others have described pathological changes in the hearts of those dying with SUDEP, including fibrosis of the walls of small coronary arteries, atrophy of cardiomyocytes, myofibrillar degeneration, edema of the conductive tissue and morphological abnormalities of the cardiac conduction system 26,29,31,34,35 .…”

Section: Sudden Unexpected Death In Epilepsymentioning

confidence: 96%

“…Information concerning risk factors for SUDEP is conflicting, but potential risk factors include: early adulthood 16 , early onset of epilepsy 22 , long duration of epilepsy 23 , uncontrolled seizures (mainly in those with TlE) 23,24 , high seizure frequency [23][24][25] , certain seizure types 23,26 , higher numbers of antiepileptic drug (AED) 22,23,27 and winter temperatures 28 . Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures, electrolyte disturbances, arrhythmogenic drugs or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a role 29,30 .…”

Section: Sudden Unexpected Death In Epilepsymentioning

confidence: 99%

“…Furthermore, others have described pathological changes in the hearts of those dying with SUDEP, including fibrosis of the walls of small coronary arteries, atrophy of cardiomyocytes, myofibrillar degeneration, edema of the conductive tissue and morphological abnormalities of the cardiac conduction system 26,29,31,34,35 . These abnormalities may be the consequence of repeated hypoxemia and/or may be associated with the increase of catecholamines during an ictal sympathetic storm 29,31,34 .…”

Section: Sudden Unexpected Death In Epilepsymentioning

confidence: 99%

“…Several studies have assessed the frequency and character of ictal cardiac rhythm during seizures 29,36,37 and the most compelling evidence derives from the presence of ictal arrhythmias 30 . when ictal cardiorespiratory variables were recorded in people with epilepsy, an increase in heart rate in 91% of 41 seizures and a transient bradycardia in five seizures (four patients) were found 38 .…”

Section: Sudden Unexpected Death In Epilepsymentioning

confidence: 99%

“…As we know, the risk of sudden death is clearly increased in the epilepsy population, and SUDEP is the most common seizure-related category 29,30,48,49 . SUDEP is mainly, but not exclusively, a problem for patients with chronic uncontrolled epilepsy 49 .…”

Section: Gustave Flaubert: Death Due Epilepsy?mentioning

confidence: 99%

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The mistery of Gustave Flaubert's death: could sudden unexpected death in epilepsy be part of the context?

Albuquerque

Scorza

Arida

et al. 2009

Arq. Neuro-Psiquiatr.

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-Epilepsy is the most common serious neurological condition and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but high seizure frequency is a potential risk factor. Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a role. More than two decades ago, temporal lobe epilepsy was suggested as having been the ''nervous disease'' of Gustave Flaubert, one of the most important French novelists. In these lines, as the circumstances of his death were the subject of fabulous and mysterious speculations, we postulated in this paper that Falubert's death could be due SUDEP phenomenon.KEy worDS: epilepsy, Gustave Flaubert, SUDEP, seizure. O mistério da morte de Gustave Flaubert: pode a morte súbita em epilepsia fazer parte o contexto ?Resumo -A epilepsia é a condição neurológica crônica grave mais comum e a morte súbita em epilepsia (SUDEP) é a mais importante causa de morte diretamente relacionada à epilepsia. Informações sobre fatores de risco para SUDEP são conflitantes, porém, a alta freqüência de crises epilépticas é um fator de risco em potencial. Além disso, os mecanismos causais para SUDEP ainda não estão conhecidos, mas é muito provável que arritmias cardíacas durante e entre as crises epilépticas ou a transmissão da atividade epiléptica para o coração via sistema nervoso autônomo desempenhem um importante papel. Mais de duas décadas atrás, foi proposto que a "doença nervosa" de Gustave Flaubert, um dos mais importantes novelistas franceses, era epilepsia do lobo temporal. Nesse sentido, como a morte de Gustave Flaubert ainda seja motivo de misteriosa especulação, nosso artigo propõe que a mesma poderia estar relacionada ao fenômeno de SUDEP.

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