Cardiopulmonary Function Studies in Workers Dealing with Asbestos and Glasswool

Bjure, J.; Söderholm, B; Widimský, J

doi:10.1136/thx.19.1.22

Cited by 24 publications

(3 citation statements)

References 15 publications

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“…However, in the present comparison of groups of individuals there was a very clear difference, with only one abnormal x-ray in the control series and 21 in the exposed series. A reduced arterial oxygen tension and a raised alveolar-arterial oxygen difference have been reported by a number of workers (Wright, 1955;Williams and Hugh-Jones, 1960b;Bjure, Soderholm, and Widimsky, 1964). Reduced lung volumes without airway obstruction were also found.…”

Section: Discussionmentioning

confidence: 64%

Insulation workers in Belfast. 1. Comparison of a random sample with a control population

Langlands

1971

Occupational and Environmental Medicine

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Section: Discussionmentioning

confidence: 64%

Insulation workers in Belfast. 1. Comparison of a random sample with a control population

Langlands

1971

Occupational and Environmental Medicine

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“…Reduced transfer factor and restrictive ventilatory impairment are a common functional profile. Other types of profile are, however, reported (Bjure et al, 1964;Muldoon and Turner-Warwick, 1972;Fournier-Massey and Becklake, 1975). Chronic bronchitis may modify the results of functional studies.…”

mentioning

confidence: 99%

TruCutR needle biopsy in asbestosis and silicosis: correlation of histological changes with radiographic changes and pulmonary function in 41 patients.

Tukiainen¹,

Taskinen²,

Korhola³

et al. 1978

Occupational and Environmental Medicine

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A percutaneous needle biopsy was performed with a TruCutR needle on 41 patients with suspected pneumoconiosis. Patients selected for biopsy tended to have brief or unusual dust exposure, as well as questionable radiographic opacities. Sixteen had been exposed to asbestos, 13 to silica and 12 to mixed dust containing quartz, coal, iron, asbestos and talc. All patients in the asbestos group and most in the other two groups had a reduced transfer factor. Most patients in the asbestos group and about 25 % of the other patients had restrictive ventilatory impairment. Chest radiographs were assessed according to standard films of the ILO U/C International Classification (International Labour Office, 1972). In 25 patients radiographic opacities were absent or scanty (categories 0-1/1). The dominant radiographic feature of many patients exposed to asbestos was a ground-glass appearance or a bilateral elevation of the diaphragm, or both, features difficult to assess according to the ILO U/C scheme. Most histological changes were those usually seen in pneumoconiosis. However, in only two patients with silicosis were silicotic nodules detected. The specimens of seven patients showed a granulomatous inflammation. The severity of alveolar wall involvement correlated well with the transfer factor value but poorly with radiographic changes. The profusion of radiographic opacities also correlated poorly with functional impairment. As a diagnostic tool the needle biopsy was valuable in asbestosis and slightly less so in mixed-dust fibrosis. The biopsy specimens showed changes compatible with asbestosis in 75% of the suspected cases and in 86% of those in which asbestosis was the final diagnosis. In the mixed-dust group pneumoconiosis was confirmed in 67 % and 80 %, respectively. In the diagnosis of silicosis an open biopsy is probably more reliable than a percutaneous one, particularly if radiographic changes are minimal. Histological changes in the needle biopsy specimen were compatible with silicosis in only 36 % of the suspected cases and in 63 % of those in which the final diagnosis was silicosis.

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“…The pattern of lung function changes in asbestosis is characterized by a restrictive ventilatory insufficiency with impairment of gas exchange in re lation to a pulmonary diffuse fibrosis [Marks et al, 1957;Read and Wil liams, 1959;Leathart, 1960;Bader et al, 1961Bader et al, ,1965; H eard and Williams, 1961; Rubino et al, 1961;Bjure et al, 1964;G aly and Pellet, 1964;Sartorelli, 1963Sartorelli, , 1964Sartorelli et al, 1964; Thomson et al, 1965;Becklake et al, 1970;Langlands et al, 1971], It is interesting to note that a reduction in pulmonary diffusing capacity for CO, both with single breath and steady-state methods, was frequently demonstrated in asbestos-exposed subjects with very slight radiographic changes and also with normal X-ray [Williams, 1964;Leathart, 1968;Sartorelli, 1966;Kleinfeld et al, 1966;H arries, 1969].…”

mentioning

confidence: 99%

Lung Function in Relation to Radiographic Changes in Asbestos Workers

et al. 1973

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A functional study involving VC, FEV 1.0 sec, RV, steady-state DLCO and fractional CO up- take at rest and, where possible, at two exercise levels (50 and 100 W), has been carried out on 724 male subjects exposed to asbestos dust inhalation. Subjects were divided into 5 groups according to UICC radiological classification of Cincinnati (1970): group 1 0/0–0/1, with asbestos exposure of less than 10 years; group II 0/0–0/1, with asbestos exposure of more than 10 years; group III 1/0–1/1, group IV 1/2–2/1–2/2 and group V 2/3–3/2–3/3. The following results were obtained: obstructive ventilatory insufficiency was observed in a percentage of cases variable between 11.2 and 24.2% in the different groups; restrictive ventilatory insufficiency was observed in 5.6% of subjects in group I, 10.1 % in group II, and 31.1–41.9–69.2%, respectively, in groups III, IV and V; impairment of gas exchange at rest and during exercise (reference to the lowest values obtained in 123 normal male subjects) was found in 4.6–6.4% of subjects in group I, 9.6–19.2% of subjects in group II and in a percentage of above 20% (till 100 %) in groups III, IV and V. Low values of DLCO in some cases of asbestos-exposed workers without radiological changes and without obstructive pulmonary disease suggest that the pulmonary damage induced by asbestos fibers may determine functional alterations of gas exchanges even in the preradiological stages

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Cardiopulmonary Function Studies in Workers Dealing with Asbestos and Glasswool

Cited by 24 publications

References 15 publications

Insulation workers in Belfast. 1. Comparison of a random sample with a control population

Insulation workers in Belfast. 1. Comparison of a random sample with a control population

TruCutR needle biopsy in asbestosis and silicosis: correlation of histological changes with radiographic changes and pulmonary function in 41 patients.

Lung Function in Relation to Radiographic Changes in Asbestos Workers

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