Cardiopulmonary exercise test predicts sustained ventricular arrhythmias in chronic heart failure

Correale, Michele; Passero, Tommaso; Totaro, Antonio; Greco, C; Rosa, Fiorella De; Concilio, Morena; Abbruzzese, S.; Acanfora, Gianfranco; Ieva, Riccardo

doi:10.1007/s12471-012-0339-x

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Our results show that low peak VO2 is associated with a long-term occurrence of MVA. These results are similar to findings of Correale et al (2013, 36-43), they found that patients with heart failure and episodes of sustained ventricular tachycardia had lower peak VO2 values [17].…”

Section: Discussionsupporting

confidence: 92%

Reduced exercise tolerance is associated with a higher risk of malignant ventricular arrhythmias

García-Saldivia¹,

Lopez-Garcia²,

Franco-Ojeda³

et al. 2019

The Assessment of Cognitive Function Determines the Time of Operation of Hydrocephalus Drainage in Severe TBI

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Keywords:Exercise test heart failure cardiovascular disease implantable defibrillator sudden death ventricular arrhythmia VO2 A B S T R A C T Malignant ventricular arrhythmia (MVA) is one of the most frequent causes of mortality among patients with cardiovascular disease. Exercise tolerance is a powerful variable to evaluate the cardiopulmonary system condition. The proposal of this research is to establish an association between peak oxygen uptake (VO2) and the incidence of long-term malignant ventricular arrhythmia. Methods:A historical cohort of patients with heart disease of a third level hospital of cardiology were studied. Every patient performed a symptoms-limited cardiopulmonary exercise testing and were followedup to10 years. We defined malignant ventricular arrhythmia (MVA) as a combined outcome composed by tachycardia or ventricular fibrillation, implantation of a cardioverter (ICD) or sudden death. Patients were split in 2 groups according to MVA. Using a ROC curve, peak VO2 was divided in two groups, according to a 25 mlO2/kg/min cut-point. Bivariate analysis identified those variables associated with MVA, that were included in a multivariable regression Cox model. All p values less than 0.05 were considered stochastically significant.Results: A total of 1767 individuals were studied, and 116 combined outcomes occurred. After Cox regression analysis, four variables were identified as statistically significant risk-factors for MVA: reduced VO2 (HR 1.75, CI 95% 1.04 to 2.92), heart failure (HR 6.15, CI 95% 2.85 to 13.21), history of ICD (HR 2.12, CI 95% 1.26 to 3.55) and diuretic use (HR 2.6, CI 95% 1.6 to 4.2). Conclusion:Maximal exercise tolerance is strongly associated with a long-term occurrence of malignant ventricular arrhythmia, together with other variables such as heart failure, history of previous ICD or diuretic use.

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Section: Discussionsupporting

confidence: 92%

Reduced exercise tolerance is associated with a higher risk of malignant ventricular arrhythmias

García-Saldivia¹,

Lopez-Garcia²,

Franco-Ojeda³

et al. 2019

The Assessment of Cognitive Function Determines the Time of Operation of Hydrocephalus Drainage in Severe TBI

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show abstract

“…Patients underwent pulmonary and cardiology assessment by clinical examination and assessed by CPET and RHC as reported elsewhere . Medical history, heart rate, systolic blood pressure, body mass index, NYHA class and medications were recorded.…”

Section: Methodsmentioning

confidence: 99%

Cardiopulmonary exercise test predicts right heart catheterization

Correale

Tricarico

Ferraretti

et al. 2017

Eur J Clin Investigation

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“…As for many chronic diseases, however, the correlations between symptoms and the degree of cardiac impairment at rest, and between symptoms and disease prognosis, are poor in patients with HF [3]. Indeed, our understanding of the exact mechanisms of progressive intolerance to exercise is far from complete.…”

Section: Introductionmentioning

confidence: 99%

Exercise training in chronic heart failure: mechanisms and therapies

Piepoli

2012

Neth Heart J

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Decreased exercise capacity negatively affects the individuals' ability to adequately perform activities required for normal daily life and, therefore, the independence and quality of life. Regular exercise training is associated with improved quality of life and survival in healthy individuals and in cardiovascular disease patients. Also in patients with stable heart failure, exercise training can relieve symptoms, improve exercise capacity and reduce disability, hospitalisation and probably mortality. Physical inactivity can thus be considered a major cardiovascular risk factor, and current treatment guidelines recommend exercise training in patients with heart failure in NYHA functional classes II and III. Exercise training is associated with numerous pulmonary, cardiovascular, and skeletal muscle metabolic adaptations that are beneficial to patients with heart failure. This review discusses current knowledge of mechanisms by which exercise training is beneficial in these patients.

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Cardiopulmonary exercise test predicts sustained ventricular arrhythmias in chronic heart failure

Abstract: CPX provides prognostic independent information for risk of SVA in subjects with CHF.

Cited by 6 publications

References 23 publications

Reduced exercise tolerance is associated with a higher risk of malignant ventricular arrhythmias

Reduced exercise tolerance is associated with a higher risk of malignant ventricular arrhythmias

Cardiopulmonary exercise test predicts right heart catheterization

Exercise training in chronic heart failure: mechanisms and therapies

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