Cardiopulmonary effects of two constant rate infusions of dexmedetomidine in isoflurane anaesthetized ponies

Marcilla, Miguel Gozalo; Schauvliege, Stijn; Duchateau, Luc; Gasthuys, Frank

doi:10.1111/j.1467-2995.2010.00537.x

Cited by 29 publications

(47 citation statements)

References 43 publications

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“…According to the results of Marcilla et al [16] aconstant rate infusion of dexmedetomidine produced similar cardiovascular effects in isoflurane anaesthetized horses independent of infusion rates used (1 and 1.75 μg•kg −1 •hour −1 ). We used the second rate as it is considered equipotent to CRI of the other alpha-2 agonists described in the introduction section [20].…”

Section: Discussionmentioning

confidence: 92%

“…Administration of dexmedetomidine as an adjunctive agent to isoflurane anaesthesia produced an anaesthetic-sparing effects in human [13] [14] and dogs [15]. Its effects were studied on isoflurane anaesthetized horses by Marcilla et al [16] [17]. In the former investigation the authors found out that the two CRIs used (1 and 1.75 µg•kg −1 •hour −1 ) produced similar, small cardiopulmonary effects within an acceptable clinical range; in the former study they claimed that dexmedetomidine CRI at 1.75 µg•kg −1 •hour −1 after a bolus of 3.5 µg•kg −1 did not reduce EtIso but improved recovery quality.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Dexmedetomidine Continuous Rate Infusion (CRI) on Isoflurane Anaesthesia in Healthy Horses

Sleiman¹,

Dinev²,

Simeonova³

2016

IJCM

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The concept of the modern anaesthesiological technique partial intravenous anaesthesia (PIVA) is by means of infusion of different pharmacological agents as a supplement to inhalation anaesthetics to reduce the concentration of volatile agents maintaining surgical anaesthesia and to decrease their noxious side effects mainly on cardiovascular and respiratory systems. Alpha-2 agonists are agents with frequent use in equine practice either as sedatives or in general anaesthesia PIVA protocols. The most selective amongst them, dexmedetomidine, is characterized by fewer side effects, lower doses, and fast elimination which make it appropriate for application as a continuous rate infusion (CRI). The purpose of this study was to trace out the effects of dexmedetomidine continuous rate infusion (CRI) as part of PIVA using isoflurane on volatile agent requirements, cardiovascular function, respiration and coagulation parameters, and recovery in healthy horses. Six healthy horses with average age 9.0 ± 5.1 year and mean body weight 247.7 ± 71.4 kg were subjected to either 3-hour lasting isoflurane or isoflurane-dexmedetomidine anaesthesia two weeks apart. The main clinical and anaesthesiological parameters were monitored in 10 minutes intervals. Electrolytes, acid-base, blood gases, and coagulation parameters were measured at the beginning and at the end of each anaesthesia. Recovery times and qualities were also recorded. The results showed that, the addition of dexmedetomidine by CRI at 1.75 μg•kg −1 •hour −1 to isoflurane anaesthesia slightly reduced isoflurane requirement for maintenance of surgical anaesthesia but had negligible effects on the recovery time and quality. PIVA using dexmedetomidine and isoflurane produced respiratory acidosis similar to isoflurane anaesthesia alone but with significantly more pronounced hypoxaemia and hyperlactaemia. Both investigated anaesthesia protocols did not influence significantly haemocoagulation parameters.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Effects of Dexmedetomidine Continuous Rate Infusion (CRI) on Isoflurane Anaesthesia in Healthy Horses

Sleiman¹,

Dinev²,

Simeonova³

2016

IJCM

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“…In a clinical, blinded, placebo‐controlled, randomized study with 40 adults, healthy, client‐owned horses, undergoing surgical procedures under general anaesthesia for more than 60 min, the limited cardiopulmonary effects of the 1.75 μg kg −1 hr −1 rate described in Marcilla et al. () were confirmed (Marcilla, Schauvliege, Segaert, Duchateau, & Gasthuys, ). After the 3.5 μg/kg sedation dose, 11 horses required additional doses to obtain acceptable sedation before induction of general anaesthesia.…”

Section: Reported Studies (2005–2017)mentioning

confidence: 88%

“…Based on Bettschart‐Wolfensberger et al. (), Marcilla, Schauvliege, Duchateau, and Gasthuys () designed an experimental study with six adults, healthy ponies. Each pony was anaesthetized once for 150 min, with periods of 30 min alternating saline with low and high doses of dexmedetomidine.…”

Section: Reported Studies (2005–2017)mentioning

confidence: 99%

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Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)

Gozalo-Marcilla

Gasthuys

Luna

et al. 2017

Vet Pharm & Therapeutics

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The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005. We also aimed to answer the question whether the use of dexmedetomidine can currently be justified. For that, we compiled information from databases, such as PubMed, Google Scholar and Web of Science and the proceedings of the last veterinary anaesthesiology meetings. Dexmedetomidine is an attractive drug to be used in horses, mainly due to its pharmacokinetic profile and pharmacodynamics that favour its use as intravenous constant rate infusion (CRI). Nowadays, its clinical use is popular for sedation in prolonged standing procedures and during partial intravenous anaesthesia (PIVA) and total intravenous anaesthesia (TIVA). However, legal requirements for its use should be taken into account.

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General Anesthesia in the Recumbent Horse

Grubb¹

2012

Advances in Equine Laparoscopy

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Cardiopulmonary effects of two constant rate infusions of dexmedetomidine in isoflurane anaesthetized ponies

Cited by 29 publications

References 43 publications

The Effects of Dexmedetomidine Continuous Rate Infusion (CRI) on Isoflurane Anaesthesia in Healthy Horses

The Effects of Dexmedetomidine Continuous Rate Infusion (CRI) on Isoflurane Anaesthesia in Healthy Horses

Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)

General Anesthesia in the Recumbent Horse

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