Cardiopulmonary effects during anaesthesia induced and maintained with propofol in acepromazine pre-medicated donkeys

Naddaf, Hadi; Baniadam, Ali; Rasekh, Abdolrahman; Arasteh, Abdolmajid; Sabiza, Soroush

doi:10.1111/vaa.12138

Cited by 7 publications

(6 citation statements)

References 7 publications

(31 reference statements)

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“…The present case report describes different treatment strategies and their effectiveness. Hypoxaemia is a known and common adverse effect in anesthetised horses 2,3 and has also been shown in other equids 16–18 …”

Section: Discussionmentioning

confidence: 97%

“…Hypoxaemia is a known and common adverse effect in anesthetised horses 2,3 and has also been shown in other equids. [16][17][18] The development of hypoxaemia in this mule was not expected because the mule was small and positioned in lateral recumbency. Both factors could be anticipated to help maintain arterial oxygenation.…”

Section: Discussionmentioning

confidence: 97%

“…Besides differences in drug requirements, no major relevant anatomical or physiological differences in pulmonary function are expected between horses, donkeys and mules 15 . The amount of research is sparse, but it has been shown that these species develop hypoxaemia under general anaesthesia similarly to the horse 16–19 . However, mules exist in a wide variety of weights and body shapes, which may lead to large variations in the development of hypoxaemia 15…”

Section: Introductionmentioning

confidence: 99%

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Successful management of hypoxaemia in a mule during general anaesthesia

Hoeberg

Levionnois

Andreis

2021

Vet Record Case Reports

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An 8-year-old, 167 kg mule was scheduled for surgical treatment of a hip luxation in lateral recumbency. During general anaesthesia, after a short phase of spontaneous breathing followed by mechanical ventilation at standard settings, the mule developed hypoxaemia (arterial oxygen partial pressure (PaO 2 ) 8.3 kPa). First, respiratory rate, tidal volume and fraction of inspired oxygen (FiO 2 ) were increased; 5 cmH 2 0 of positive end-expiratory pressure (PEEP) and nebulized salbutamol were administered. Second, three vital capacity manoeuvres were executed (tidal volume of 20 ml kg −1 ). No immediate improvement in PaO 2 (8.0 kPa) was observed. A further recruitment manoeuvre with increased peak inspiratory pressure (up to 44 cmH 2 O) and PEEP (25 cmH 2 O) was performed. Over the following 120 min, PaO 2 increased progressively. The mule recovered without complications. This case reports that mules can develop hypoxaemia during general anaesthesia that can be treated with recruitment manoeuvres. However, the effect may not be immediate.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Successful management of hypoxaemia in a mule during general anaesthesia

Hoeberg

Levionnois

Andreis

2021

Vet Record Case Reports

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“…The association of alpha 2 -agonists and muscle relaxants produces less cardiovascular depression in ponies and horses [25][26][27][28][29][30][31]. A variety of TIVA protocols have been set up for different kinds of surgery in horses, although little is documented for donkeys and mules [32,33]. This type of general anaesthesia is generally preferred in miniature or in young donkeys because of the difficult orotracheal intubation, related to the different anatomical features of the larynx compared to horses [34].…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effect of Butorphanol during Castration in Donkeys under Total Intravenous Anaesthesia

Straticò

Carluccio

Varasano

et al. 2021

Animals

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Pain management is necessary for all surgical procedures. Little scientific evidence about drug efficacy in donkeys is available. The aim of this study was to evaluate the analgesic effect of butorphanol in donkeys undergoing orchiectomy under total intravenous anaesthesia with guaifenesin-ketamine-detomidine. A randomized blinded prospective clinical trial (Protocol n. 2021/0000338), was carried out on 18 clinically healthy donkeys undergoing bilateral orchiectomy. Patients were assigned to Group D (n = 8) or Group DB (n = 10) if receiving intravenous detomidine or detomidine-butorphanol respectively, before induction of general anaesthesia with ketamine-diazepam. Intraoperative muscle relaxation, nystagmus, palpebral reflex, heart and respiratory rate, and non-invasive blood pressure were evaluated every 2 min; time to prepare the patient, duration of surgery and anaesthesia and recovery score were recorded. Group D had significantly longer surgical time, higher heart rate, higher systolic and mean blood pressure (p < 0.05; repeated measure ANOVA), increased muscle rigidity and expression of palpebral reflex (p < 0.05; Mann–Whitney U test) than group DB. Top-ups with thiopental were statistically higher in Group D. Butorphanol and detomidine together produced a more stable anaesthetic plan. The low dosage of opioid and alpha-2-agonists and reduced rescue anaesthesia are responsible for a safer and more superficial anaesthesia, which is mandatory under field conditions.

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“…It inhibits the N-methyld-aspartate receptor and modulates calcium influx through slow calcium-ion channels by directly activates gamma-aminobutyric acid receptors [3]. Cardiopulmonary effects are stable when administration the continuous infusion rate of propofol for maintenance of anesthesia in donkeys [4]. Thiopental sodium is an ultrashort acting barbiturate; that possesses muscle relaxant and poor analgesia properties [5].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of Propofol and Thiopental Sodium for Gastrotomy in Rabbits

Menghwar¹

2021

PAB

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This study showed that heart and respiratory rate of all rabbits after administration of Xylazine HCL was decreased in both treatments. The body temperature was decreased throughout the period of anesthesia with both types of anesthesia and xylazine as compared to the control values. Comparison of the both treatments showed that there was no significant difference (P= 0.6258) found in body temperature during anesthesia. However, Xylazine HCl produced a mild degree of sedation within 2.33±0.25 and 2.5±0.18 minutes with both treatments (A and B) respectively. The mean time required for induction of anesthesia after administration of different anesthetic drugs was 29±1.53 and 56±1.93 seconds with both treatments A and B respectively. Results showed that the induction was smooth and rapid with propofol (treatment A) than thiopental sodium (treatment B). While, duration of anesthesia was 22±1.71 and 57.5±2.81 minutes after induction with treatment A and B respectively. Surgical anesthesia (stage 3-plane 3) occurred at 5 to 25 minutes and (stage 3-plane 2) at 5 to 40 minutes were recorded in treatments (A and B) respectively. The mean duration of analgesia was 26.67±2.11and 60±1.83 minutes with treatment with A and B respectively. Degree of analgesia and degree of muscle relaxation was deep with treatment A as compared to treatment B. Recovery from anesthesia was shorter 8.17±1.05 with treatment A than18.33±1.67 minutes treatment with B. It is concluded that propofol produced safest, rapid anesthesia in all rabbits for gastrotomy than thiopental sodium in rabbits.

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Cardiopulmonary effects during anaesthesia induced and maintained with propofol in acepromazine pre-medicated donkeys

Cited by 7 publications

References 7 publications

Successful management of hypoxaemia in a mule during general anaesthesia

Successful management of hypoxaemia in a mule during general anaesthesia

Analgesic Effect of Butorphanol during Castration in Donkeys under Total Intravenous Anaesthesia

Comparative study of Propofol and Thiopental Sodium for Gastrotomy in Rabbits

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