Cardioprotective effects of curcumin-loaded magnetic hydrogel nanocomposite (nanocurcumin) against doxorubicin-induced cardiac toxicity in rat cardiomyocyte cell lines

Abstract

Curcumin, is a yellow substance extracted from Curcuma longa rhizomes, it is a crystalline compound that has been traditionally applied in culinary practices and medicines in India. The aim of our study is to demonstrate the efficacy of curcumin-loaded magnetic hydrogel nanocomposite in the treatment of heart hypertrophy. 10 rats weighing 150-200 g each were induced with heart failure using 2.5 mg/kg doxorubicin for 2 weeks. The test groups were treated with curcumin-loaded magnetic hydrogel nanocomposite while the control was treated with curcumin alone. malondialdehyde (MDA) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPX) enzymes activities were monitored after two weeks of last the dose. In addition, the expression of three heart failure markers; atrial natriuretic peptide (ANP), B type natriuretic peptide (BNP), and beta major histocompatibility complex (β-MHC) were observed, it was found that the expression of these markers decreases with an increase in the concentration of curcumin (P < 0.05). Curcumin elevated the decreased level of GPX and SOD, and reduced the elevated level of MDA in cardiac tissue. We suggest this combination to be a potent therapy for heart failure and hypertension in the nearest future.

A complex micellar system co-delivering curcumin with doxorubicin against cardiotoxicity and tumor growth

“…It has been reported that the protective effect of CUR on acute DOX-induced toxicity is related to its antioxidant capacity. 33 Measurements of those biomarkers in the rat model further demonstrated the involvement of free radical over-formation and oxidative stress in DOX-induced cardiotoxicity. In contrast with the control, free DOX alone treatment caused a remarkable elevation of MDA and escalating levels of SOD and GSH-Px in rat heart tissue, which could be significantly improved by CPDMC but not the cocktail formulation at same dosages.…”

Sulforaphane protection against the development of doxorubicin‐induced chronic heart failure is associated with Nrf2 Upregulation

“…Rats were randomly allocated into four groups (n=30 per group): control, SFN, DOX and DOX plus SFN (DOX/SFN) groups. Rats in the DOX and DOX/SFN groups were intraperitoneally injected with DOX (TCI Chemical Industry Development Inc., Tokyo, Japan) dissolved in saline at 2.5 mg/kg body weight every other day for six times, and the accumulated dose was 15 mg/kg . SFN (Sigma‐Aldrich, St Louis, MO, USA) dissolved in 1% dimethyl sulfoxide (DMSO) and diluted in saline was subcutaneously administered at 0.5 mg/kg every day in rats in the SFN and DOX/SFN groups.…”

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

“…In 2017, Namdari and Eatemadi [198] demonstrated the cardioprotective effect of CUR-loaded magnetic hydrogel nanocomposite (Cur-NIPAAM-MAA-NP) against doxorubicin-induced cardiac toxicity in rats. They reported that the nanoparticles were successfully synthetized with 91% of efficiency of entrapment.…”