Cardioprotective Effects of Aqueous Extract of <i>Salvia miltiorrhiza</i> on Heart Failure is Related to SDF-1/CXCR4 Axis and Bcl-2 Family Expressions

Abstract

Salvia Miltiorrhizae Bge, a popular Chinese herb has been widely adopted for use in Chinese hospitals for both the prevention and the active management of cardiovascular disease. there is no study on its cardioprotective effects against HF and more importantly, the underlying mechanisms of its beneficial effects by SDF-1/CXCR4 axis remain poorly understood. This study was performed to investigate the protective effects and possible mechanism of aqueous extract of Salvia miltiorrhiza (AESM) on HF rats. In the study, cardioprotective effects of AESM on HF rats was evaluated by herat function, myocardial pathology, myocardial cell proliferation, SDF-1, CXCR4 and Bcl-2 family mRNA expressions. In the experiment, we found that AESM exerted beneficially protective effects on the HF rats, mainly recoverying normal heart function, myocardial pathology and myocardial cell proliferation. The underlying mechanism of these protective effects of AESM appeared to involve improving the SDF-1/CXCR4 axis and Bcl-2 family expressions.

Simultaneous Determination of Four Tanshinones by UPLC-TQ/MS and Their Pharmacokinetic Application after Administration of Single Ethanol Extract of Danshen Combined with Water Extract in Normal and Adenine-Induced Chronic Renal Failure Rats

“…Salvia miltiorrhiza , a traditional Chinese herbal medicine, derived from the root of Salvia miltiorrhiza and belonging to the Salvia genus of family of Labiatae, has been used widely in clinics for the treatment of coronary heart diseases, particularly angina pectoris and myocardial infarction [1,2]. Previous research demonstrated that Salvia miltiorrhiza possessed various pharmacological effects for improving cerebral ischemia reperfusion injury, blood rheology, platelet function, anti-hypertensive, anti-inflammatory, and protecting the cardiovascular system [3,4,5,6,7].…”

Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia

“…Salvia miltiorrhiza Bge., belonging to the Salvia genus of family of Labiatae, has been widely used for the treatment of coronary heart diseases, angina, cerebrovascular disease and hypertension (Cao et al, ; Cheng, ; Chinese Pharmacopoeia Commission, ; Kang, Yun, Ryoo, & Lee, ; Li, Wang, Feng, & Yang, ; Sun et al, ; Takeo et al, ; Zhang et al, ). The major active compounds in S. miltiorrhiza mainly include hydrosoluble salvianolic acids and liposoluble tanshinones (Gu, Zhang, Su, & Ouyang, ; Liu et al, ; Liu, Guo, Ye, Lin, & Guo, ; M. Liu et al, ; Ma, Zhang, Zhang, & Gan, ; Qiao et al, ; Yang et al, ).…”