Cardioprotective effects of acute isovolemic hemodilution in a rat model of transient coronary occlusion*

Abstract

Our data provide the first experimental demonstration that preischemic moderate AIH confers cardioprotection and improves survival in a rat model of myocardial infarct.

Relationship between blood viscosity and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

“…Moreover, hemodilution could be another therapeutic strategy, though these patients are already hemodiluted because of intravenous hydration; however, few data are available from studies performed in experimental animals [32][33][34] and in humans [35].…”

Impact of Blood Transfusion on Short- and Long-Term Mortality in Patients With ST-Segment Elevation Myocardial Infarction

“…Whether these changes account for the majority of in vivo adverse outcomes associated with transfusion is uncertain at this time (23,38,39). It has been suggested that, with increased hemoglobin, the platelets are exposed to increased shear forces, which increases platelet aggregation toward the vessel wall and may worsen ischemia (40,41).…”

Anemia and perioperative red blood cell transfusion: A matter of tolerance

“…It has recently been shown that ANH to the same degree in CAD patients undergoing on-pump coronary artery bypass graft surgery results in a lower release of markers of myocardial injury, a lower need for dobutamine, and a decreased incidence of postoperative arrhythmias compared with the nonhemodiluted control group (32). Similarly, the same study group demonstrated the cardioprotective effects of moderate acute isovolemic hemodilution in rats before coronary occlusion leading to myocardial infarction (33). Hemodiluted animals showed a smaller myocardial infarct size, a lower incidence of fatal ventricular tachyarrhythmias, and a higher survival (33).…”

“…Similarly, the same study group demonstrated the cardioprotective effects of moderate acute isovolemic hemodilution in rats before coronary occlusion leading to myocardial infarction (33). Hemodiluted animals showed a smaller myocardial infarct size, a lower incidence of fatal ventricular tachyarrhythmias, and a higher survival (33).…”