Cardioprotective effects of 44Bu, a newly synthesized compound, in rat heart subjected to ischemia/reperfusion injury

Başgut, Bilgen; Kayki, Gizem; Bartošová, Ladislava; Özakça, Işıl; Seymen, Aytac; Kandilci, Hilmi Burak; Uğur, Mehmet; Turan, Belma; Özçeli̇kay, A.Tanju

doi:10.1016/j.ejphar.2010.04.045

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…It also exerted the most pronounced arrhythmogenic effects and the QRS duration was slightly prolonged. We may assume that these phenomena may be caused by a blocking of ion channels, similar to substances tested in the last few years (Brunton et al 2006;Basgut et al 2010;Tengler et al 2013b). Butyl derivatives exhibited the most promising effects in the present study, in that they reduced blood pressure without any interference with other heart parameters investigated.…”

Section: Discussionsupporting

confidence: 73%

Influence of new ultra-short-acting β-blockers on selected physiological indicators in laboratory rats

Baďo¹,

Dlouhá²,

Kolmanová³

et al. 2017

Vet. Med. - Czech

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High rates of cardiovascular mortality have long been a serious problem in all European countries. Despite advancements in health care the situation is not improving fast enough. In the last decades, no new ultra-short-acting β-blockers have been registered in the European Union except for esmolol and landionol. In this study, eight newly-synthesised ultra-short-acting β-blockers were tested. These β-blockers contain an ester functional group which can be easily cleaved by plasma or cytoplasmic esterases. The substances were prepared in the Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno. Systolic blood pressure, heart rate and the interval of the QRS complex were evaluated using normotensive laboratory Wistar rats. The tested compounds were administered intravenously into the vena jugularis during general anaesthesia. The arteria carotis was exposed and cannulated to a Universal Perfusion System Basic Unit (UPSBU) of type Uniper UP-100. The universal perfusion system for isolated organs was capable of measuring and transducing actual values of blood pressure. ECG records were made using the ECG SEIVA – Praktik Veterinary. A series of substances named 2FC2a, 2FC2b, 2FC2c, 2FC2d, and another series with substances named 2FT2a, 2FT2b, 2FT2c, 2FT2d were tested at a dose of 3 mg/kg. Results were statistically compared to placebo. The best results were obtained for propyl and butyl derivatives with the highest lipophilicity. These acted as the best blood pressure reducers immediately after their administration. None of the compounds notably affected the heart rate. Statistical data show that carbamate substitution considerably prolongated the duration of the QRS complex as compared to placebo or etheric substitution. The carbamate substitution caused a pronounced arrhythmogenic effect. Thus, we could confirm the short-term hypotensive effect of the compounds. We observed an effect on the electrical conduction system of the heart while no effects were observed on heart rate. Our study contributes to better describing potential new ultra-short-acting β-blockers and facilitates selection for further testing.

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Section: Discussionsupporting

confidence: 73%

Influence of new ultra-short-acting β-blockers on selected physiological indicators in laboratory rats

Baďo¹,

Dlouhá²,

Kolmanová³

et al. 2017

Vet. Med. - Czech

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“…Ischemia and reperfusion (IR) injuries are a primary cause of cardiac failure, morbidity, and mortality after cardiac operations [4,37] and heart infarctions [20,21]. The primary focus in treating myocardial infarction in clinical settings of cardiac surgery and reperfusion therapy has become how to salvage the viable myocardial tissue and restore its electrical and mechanical functions [41].…”

Section: Introductionmentioning

confidence: 99%

The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway

et al. 2012

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In this study, we evaluated the effect of curcumin (Cur) post-treatment on isolated perfused rat hearts that had been subjected to a protocol of ischemia and reperfusion injury. We also examined whether the Janus kinase 2 and signal transducer and activator 3 of transcription (JAK2/STAT3) signaling pathway plays a role in the cardioprotective effects of Cur post-treatment. Isolated perfused rat hearts were subjected to 60 min of ischemia, followed by 60 min of reperfusion. The hearts were exposed to 1-μM Cur during the first 10 min of reperfusion in the absence or presence of the JAK kinase-specific inhibitor AG490 (AG, 1 μM). The Cur treatment conferred a cardioprotective effect, and the treated hearts demonstrated an improved post-ischemic cardiac functional recovery, a decreased myocardial infarct size and decreased lactate dehydrogenase release in the coronary flow, a reduced number of apoptotic cardiomyocytes, up-regulation of the anti-apoptotic protein Bcl2 and down-regulation of the pro-apoptotic protein Caspase3. AG blocked the Cur-mediated cardioprotection by inhibiting the JAK2/STAT3 signaling pathway, as reflected by the abrogation of the Cur-induced up-regulation of Bcl2 and down-regulation of Caspase3. The results suggest that Cur post-treatment can attenuate IR injury through the activation of the JAK2/STAT3 signaling pathway, which transmits a survival signal to the myocardium.

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Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles

Huang

Chen

Huang

et al. 2020

Neurosecretion: Secretory Mechanisms

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Cardioprotective effects of 44Bu, a newly synthesized compound, in rat heart subjected to ischemia/reperfusion injury

Cited by 5 publications

References 29 publications

Influence of new ultra-short-acting β-blockers on selected physiological indicators in laboratory rats

Influence of new ultra-short-acting β-blockers on selected physiological indicators in laboratory rats

The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway

Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles

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