2010
DOI: 10.1016/j.vph.2010.04.002
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Cardioprotective effect with carbon monoxide releasing molecule-2 (CORM-2) in isolated perfused rat heart: Role of coronary endothelium and underlying mechanism

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Cited by 35 publications
(28 citation statements)
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“…Moreover, CORM-2 showed significantly improved post-ischaemic recovery of heart rate, coronary flow rate, cardiodynamic parameters and reduced infarct size (Soni et al, 2012). PC with CORM-2 in rat isolated hearts markedly decreased LDH and CK levels in coronary effluent after global ischaemia, providing also a significant improvement in coronary flow rate, heart rate, cardiodynamic parameters and marked attenuation in infarct size (Soni et al, 2010). In addition, marked LV dysfunction following coronary artery occlusion and reperfusion was ameliorated by CORM-3 in mouse hearts (Clark et al, 2009).…”
Section: Experimental Model Effect Of H2s Proposed Mechanism(s) Refermentioning
confidence: 91%
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“…Moreover, CORM-2 showed significantly improved post-ischaemic recovery of heart rate, coronary flow rate, cardiodynamic parameters and reduced infarct size (Soni et al, 2012). PC with CORM-2 in rat isolated hearts markedly decreased LDH and CK levels in coronary effluent after global ischaemia, providing also a significant improvement in coronary flow rate, heart rate, cardiodynamic parameters and marked attenuation in infarct size (Soni et al, 2010). In addition, marked LV dysfunction following coronary artery occlusion and reperfusion was ameliorated by CORM-3 in mouse hearts (Clark et al, 2009).…”
Section: Experimental Model Effect Of H2s Proposed Mechanism(s) Refermentioning
confidence: 91%
“…The mechanism by which CORM-2 triggers PC in rat isolated hearts is probably due to the activation of the p38 MAPK β and PKC pathways before ischaemia as well as PI3-kinase pathway during reperfusion (Soni et al, 2012) and activation of the K ATP channels (Soni et al, 2010).…”
Section: Experimental Model Effect Of H2s Proposed Mechanism(s) Refermentioning
confidence: 99%
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“…CO (or CORM) also modulates non-cardiac ion channels, with potential repercussions on cardiovascular function. For example, the activation of the I KATP channel in vascular smooth muscle cells may account for the cardioprotective effect of CORM-2 observed in the perfused rat heart (Soni et al, 2010) since this effect is reversed by glibenclamide. CO also activates TREK-1 (tandem pore-domain K + channel), and inhibits native or recombinant Kv 2.1 (Dallas et al, 2011), which may be cardiprotective (Dhalla et al, 2000;Honore, 2007).…”
Section: Beneficial Effects Of Comentioning
confidence: 99%
“…In mammalian cells CO is generated by the enzyme heme-oxygenase [4]. CO participates in the regulation of a wide variety of cellular functions [5,6,7,8,9] and contributes to the regulation of cell death [10,11,12,13,14,15]. CO may elicit both vasodilation and vasoconstriction [16,17].…”
Section: Introductionmentioning
confidence: 99%