“…Experimental studies suggest that ischemic postconditioning prevents myocardial reperfusion injury and limits infarct size by inhibiting MPTP opening (Argaud et al, 2005). As with ischemic preconditioning, the mechanism through which this is achieved is not clear, but a number of potential signaling pathways have been proposed: 1) the activation of the prosurvival cardioprotective pathways, such as the RISK, SAFE, and NO-cGMP-PKG pathways, at the onset of reperfusion inhibit MPTP opening (Hausenloy et al, 2005Bopassa et al, 2006;Heusch et al, 2008Heusch et al, , 2011Boengler et al, 2011a;Andreadou et al, 2014); 2) the delayed restoration in intracellular pH may inhibit MPTP opening (Cohen et al, 2007); and 3) the reduction in ROS generated at reperfusion may prevent MPTP opening (Clarke et al, 2008).…”