Cardioprotective effect of vincristine on isoproterenol-induced myocardial necrosis in rats

Panda, Sasmita; Kar, Anand; Ramamurthy, V. V.

doi:10.1016/j.ejphar.2013.10.049

Cited by 37 publications

(23 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current b e n i -s u e f u n i v e r s i t y j o u r n a l o f b a s i c a n d a p p l i e d s c i e n c e s 3 ( 2 0 1 4 ) 2 3 9 e2 4 6 study is unique from previous literatures in the sense that it is the first to examine the cardioprotective potential of rosuvastatin, ellagic acid and, especially, their combination on isoproterenol-intoxicated rats in the presence of HL. Alterations of ECG pattern, especially ST-segment elevation, represent the standard measure used to precisely diagnose MI in humans and animals (Panda et al, 2014). In our study, HM group demonstrated a significant ST-segment elevation which could be due to the deleterious effects of isoproterenol on cardiac cell membrane integrity with subsequent reduced mechanical capacity of the ventricles (Thippeswamy et al, 2009).…”

Section: Discussionmentioning

confidence: 58%

Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Elhemely

Omar

Ain-Shoka

et al. 2014

Beni-Suef University Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

Hyperlipidemia Isoproterenol RosuvastatinEllagic acid a b s t r a c t Hyperlipidemia (HL) with subsequent coronary atherosclerosis is the major trigger of ischemia and hence, myocardial infarction (MI) occurs. The present study aimed to elucidate the effects of pretreatment with rosuvastatin and ellagic acid, as well as their combination on isoproterenol-induced MI in hyperlipidemic rats. Adult rats were fed with a cholesterol-rich diet for seven weeks and received rosuvastatin (10 mg/kg) and/or ellagic acid (30 mg/kg) by oral gavage daily starting from the fifth week then subcutaneously injected with two doses 24-h apart of 100 mg/kg isoproterenol in the last two days. ECG pattern was monitored and both cardiac biomarkers (cTnI, CK-MB, LDH and AST) and lipid profile (TC, TG, HDL-c and LDL-c) were measured in serum. MDA and GSH levels were quantified in cardiac homogenates and heart tissue damage was examined by histopathology. Furthermore, the expression levels of iNOS, eNOS, Bax and Bcl-2 in heart samples were assessed by western blotting. Three-week pretreatment with rosuvastatin and/or ellagic acid markedly ameliorated HL-and isoproterenol-induced alterations in ECG, cardiac markers, oxidation markers, lipid profile and heart architecture. Both drugs downregulated iNOS and upregulated eNOS, while only rosuvastatin and the combination downregulated Bax. This study provides evidence that rosuvastatin and ellagic acid possess cardioprotective effect on the hyperlipidemic-myocardial infarction rat model and the combination does not offer extra protection than monotherapy.

show abstract

Section: Discussionmentioning

confidence: 58%

Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Elhemely

Omar

Ain-Shoka

et al. 2014

Beni-Suef University Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Pretreatment with vincristine restored the activity of these membrane bound enzymes. In addition, it preserved mitochondrial structure, prevented the loss of cristae, and swelling of mitochondria due to ISP (Panda, Kar, & Ramamurthy, ). In a similar study, combination of vincristine and quercetin proved better against ISP‐induced toxicity compared with the individual drugs (Panda & Kar, ).…”

Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 99%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant-based interventions screened for cardioprotective effect in ISP-induced cardiotoxicity, and their probable mechanistic profile is summarized.

show abstract

“…1,2 As the pathophysiological changes induced by ISO can mimic the state of pathological changes in cardiac tissue in the progress of human heart failure, the model of ISO-induced myocardial injury has been widely used in exploring the cardioprotective effect of many drugs on cardiac function. 1,2 As the pathophysiological changes induced by ISO can mimic the state of pathological changes in cardiac tissue in the progress of human heart failure, the model of ISO-induced myocardial injury has been widely used in exploring the cardioprotective effect of many drugs on cardiac function.…”

Section: Introductionmentioning

confidence: 99%

Fuziline alleviates isoproterenol‐induced myocardial injury by inhibiting ROS‐triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway

Fan

Yao

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Fuziline, an aminoalcohol-diterpenoid alkaloid derived from Aconiti lateralis radix preparata, has been reported to have a cardioprotective activity in vitro. However, the potential mechanism of fuziline on myocardial protection remains unknown. In this study, we aimed to explore the efficacy and mechanism of fuziline on isoproterenol (ISO)-induced myocardial injury in vitro and in vivo. As a result, fuziline effectively increased cell viability and alleviated ISO-induced apoptosis. Meanwhile, fuziline significantly decreased the production of ROS, maintained mitochondrial membrane potential (MMP) and blocked the release of cytochrome C, suggesting that fuziline could play the cardioprotective role through restoring the mitochondrial function.Fuziline also could suppress ISO-induced endoplasmic reticulum (ER) stress via the PERK/eIF2α/ATF4/Chop pathway. In addition, using ROS scavenger NAC could decrease ISO-induced apoptosis and block ISO-induced ER stress, while PERK inhibitor GSK2606414 did not reduce the production of ROS, indicating that excess production of ROS induced by ISO triggered ER stress. And fuziline protected against ISO-induced myocardial injury by inhibiting ROS-triggered ER stress. Furthermore, fuziline effectively improved cardiac function on ISO-induced myocardial injury in rats. Western blot analysis also showed that fuziline reduced ER stress-induced apoptosis in vivo. Above these results demonstrated that fuziline could reduce ISO-induced myocardial injury in vitro and in vivo by inhibiting ROS-triggered ER stress via the PERK/eIF2α/ATF4/Chop pathway. K E Y W O R D Sapoptosis, ER stress, fuziline, isoproterenol, ROS | 1333 FAN et Al.

show abstract

Cardioprotective effect of vincristine on isoproterenol-induced myocardial necrosis in rats

Cited by 37 publications

References 42 publications

Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Fuziline alleviates isoproterenol‐induced myocardial injury by inhibiting ROS‐triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway

Contact Info

Product

Resources

About