Cardioprotective Effect of Phyllanthus Fraternus Leaves Extract Against Cyclophosphamide - Induced Myocardial Injury in Rats

Moirangthem, Rakesh S.; Gunindro, Ngangom; Takhellambam, Dipdeba Singh; Khuraijam, Sucheta Devi; Meena, NS; Selvatici, Rita

doi:10.22159/ajpcr.2017.v10i12.21003

Cited by 1 publication

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“…Other components are β-myrcene, β-ocimene, linalool, and E-1decenal. 8 Previous reports showed that andaliman ethyl acetate extract has cardioprotective effects 9 and free radical scavenging activity. 10 It is believed that the ethanol extract of andaliman can counteract the hematotoxic effect of doxorubicin.…”

Section: Introductionmentioning

confidence: 99%

Effect of andaliman (Zanthoxylum acanthopodium DC.) ethanol extract on doxorubicin-induced toxicity on hematology in male rats

Angela

Dalimunthe

Harahap

et al. 2023

J. Drug Delivery Ther.

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Introduction: Doxorubicin is one of the chemotherapy drugs that have harmful effects on blood hematology. Blood hematological diseases are caused by its adverse effects and anticancer properties. The antioxidant properties of several plants have been reported to be closely related to reduced toxicity in blood hematology. Andaliman (Zanthoxylum acanthopodium) ethanolic extract (AEE) is thought to reduce the toxicity of doxorubicin due to the antioxidant properties of its secondary metabolite content. This study aimed to determine the effect of AEE on doxorubicin-induced rats and its effect on blood cells. Materials and Method: A total of 24 male rats were divided into 6 groups: (1) Normal group; (2) 0.5% Na-CMC group; (3) 50 mg/kg BW quercetin group; (4) AEE 75 mg/kg BW group; (5) AEE 150 mg/kg BW group; and (6) AEE group 300 mg/kg BW administered orally for 9 days. On days 8 and 9, doxorubicin 10 mg/kg BW was administered. Rats were sacrificed for blood collection, and measured at the Integrated Laboratory of the USU Hospital. Results: AEE reduces the toxicity of doxorubicin on blood parameters. Furthermore, it affects Hb, white blood cells, platelet cells, monocytes, lymphocytes, neutrophils, and several related protein metabolisms as well as organ damage. Dose 150 or 300 mg/kg AEE reduce all blood toxins to near-normal levels and decrease the lymphocyte and neutrophil suppressive activity of doxorubicin. Conclusion: Andaliman ethanol extract can improve Hb count, white blood cells, platelet cells, monocytes, lymphocytes, neutrophils, protein metabolism, and organ damage. Furthermore, AEE can be used in combination with doxorubicin to reduce its hematological toxicity. Keywords: toxicity, hematology, doxorubicin, andaliman, Zanthoxylum acanthopodium, extract

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Section: Introductionmentioning

confidence: 99%