Cardioprotective Effect of Leaf and Root Extracts of Newbouldia laevis against Carbon Tetrachloride Induced-Cardiotoxicity in Albino Rats

Agbafor, K. N.; Ezeali, C.; Akubugwo, E. I.; Obiudu, I.K.; Uraku, A. J.; Ogbanshi, M. E.; Edwin, N.; Ugwu, Okechukwu Paul-Chima

doi:10.9734/ejmp/2015/17673

Cited by 9 publications

(10 citation statements)

References 10 publications

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“…However, some alkaloids, monoterpenes and flavonoids also have protective effects against chemically induced convulsions (Librowski et al, 2000;Johnston and Beart, 2004). The phytochemicals, alkaloids, tannins, saponins, flavonoids, anthraquinones, terpenoids and cardiac glycosides have been found in extracts of the plant (Oloyede, 2004;Agbafor et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Anticonvulsant and Analgesic Properties of Leaf and Root Extracts of Newbouldia laevis

Agbafor¹,

Ezeali²,

Akubugwo³

2015

Asian J. of Biochemistry

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Extracts of various parts of Newbouldia laevis are used traditionally in Eastern Nigeria in management and treatment of several diseases, including some neurological disorders. This study investigated anticonvulsant and analgesic potentials of leaf and root extracts. The extracts were prepared with deionized water and ethylacetate. Extracts doses of 200, 400, 600 and 800 mg kgG 1 b.wt. were used for the investigations. Anticonvulsant potential of the extracts against pentylenetetrazole-induced convulsion was tested in albino rats, by measuring time for convulsion onset, duration of convulsion and plasma glucose and Ca 2+ levels before, during and after convulsion, using diazepam as standard. The hot plate method was used to investigate the analgesic property of the extracts using morphine sulphate as standard. Pretreatment of the animals with different doses of the extracts delayed the onset of convulsion in a dose-dependent manner. Convulsion was not observed in 800 mg kgG 1 b.wt. of Deionized Water Leaf (DWL) extract and in diazepam pretreated groups. The extracts decreased significantly (p<0.05) the severity of convulsion and prolonged the duration of convulsion induced by pentylenetetrazole. The plasma concentration of glucose and Ca 2+ decreased significantly (p<0.05) in the test groups through the course of convulsion, while they did not change significantly (p>0.05) in the non-convulsed groups.All the extracts at all doses and 4 mg kgG 1 of morphine sulphate (an analgesic) showed a significant (p<0.05) percentage inhibition against hot plate induced pain. The difference between the analgesic potentials of 800 mg kgG 1 of DWL extract and 4 mg kgG 1 morphine sulphate was not significant (p>0.05). These findings indicate that the extracts may be effective in management/treatment of convulsion and pains.

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Section: Resultsmentioning

confidence: 99%

Anticonvulsant and Analgesic Properties of Leaf and Root Extracts of Newbouldia laevis

Agbafor¹,

Ezeali²,

Akubugwo³

2015

Asian J. of Biochemistry

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“…Agbafor et al in 2015 reported the cardio-protective potential of aqueous extract of leaf and root in ccl4 induced cardiotoxicity in Albino wistar rats. The extracts contained alkaloids; tannins; saponins; flavonoids; anthraquinones; terpenoids and cardiac glycosides in varied proportions which contribute to the various medicinal applications of leaves and roots of N. Laevis [81] . The phytochemical constituents of the extracts contribute to the various medicinal applications of leaves and roots of N. Laevis.…”

Section: Various Therapeutic Effects Of Newbouldia Laevis: a Review 6...mentioning

confidence: 99%

“…However; pretreatment of animals with the extracts or aspirin resulted in a significant (P <0.05) and dose-dependent prevention of elevation in the levels of CK; LDH; AST; total cholesterol; triglycerides and HDL and reduction in HDL. The cardio-protective potential may be as a result of the antioxidant property of the phyto-constituents [81] .…”

Section: Various Therapeutic Effects Of Newbouldia Laevis: a Review 6...mentioning

confidence: 99%

Newbouldia’s Laevis biological effects against metabolic syndrome components: A review

Bwegne¹,

Ayina²,

Pagnangdé³

et al. 2022

World J. Adv. Res. Rev.

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This study focused on a review of existing data on Newbouldia laevis and its potential effects on metabolic syndrome. Progressive changes in lifestyle that promote sedentary lifestyle, nutritional imbalances associated with excessive levels of refined sugars and fat that promote excess calories, and genetic factors have contributed significantly to the increase in cardiovascular disease, diabetes and the emergence of the concept of metabolic syndrome. Metabolic syndrome refers to an aggregation of factors that intervene, most often together, it is defined as a set of biological and clinical disorders whose metabolic aberrations are mainly: Insulin resistance and dysglycemia, obesity (general and abdominal), atherogenic dyslipidaemia, high blood pressure pro-inflammatory and prothrombotic states. The management of metabolic syndrome is very complex, because the components are associated differently in each patient due to the genetic susceptibility of each to develop one component over another, and the many environmental factors influencing the development of the pathology. The African continent is full of a great diversity of plant species, most of which are used by people as medicines to solve their health problems, because they are readily available. The African hyssop or Newbouldia laevis is a plant in the family Bignoniaceae. The qualitative phytochemical screening revealed the presence of alkaloids, tannins, saponins, terpenes, flavonoids, and cardiac glycosides anthraquinones in Newbouldia laevis leaf extract. Several therapeutic properties have been attributed to the plant Newbouldia laevis including anti-hyperglycemic, cardio-protective and hypotensive activity, body weight reduction, anti-inflammatory, antithrombotic, hepato-protective, antiparasitic, antibiotic. Herbal medicine is an alternative way to treat metabolic syndrome, and its importance is growing.

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“…Frederich et al [26] have studied and reported the high antiplasmodial activity of indole alkaloids isolated from natural sources. The presence of cardiac glycosides in the extract could be responsible for its folklore use in cardiovascular diseases as well as its cardioprotective effect reported by Agbafor et al [27] Tannins have been reported to possess good antioxidant activity which could further result in good antiplasmodial activity. [28] Terpenes are known to exhibit good antiplasmodial activity as they are commonly implicated in the antiplasmodial activity of medicinal plants.…”

Section: Curative Testmentioning

confidence: 99%

Antiplasmodial Activity of the Ethanol Leaf Extract of Newbouldia Laevis

Igboasoiyi¹

2017

WJPPS

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Cardioprotective Effect of Leaf and Root Extracts of Newbouldia laevis against Carbon Tetrachloride Induced-Cardiotoxicity in Albino Rats

Cited by 9 publications

References 10 publications

Anticonvulsant and Analgesic Properties of Leaf and Root Extracts of Newbouldia laevis

Anticonvulsant and Analgesic Properties of Leaf and Root Extracts of Newbouldia laevis

Newbouldia’s Laevis biological effects against metabolic syndrome components: A review

Antiplasmodial Activity of the Ethanol Leaf Extract of Newbouldia Laevis

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