Antiplasmodial Activity of the Ethanol Leaf Extract of Newbouldia Laevis

Igboasoiyi, Arnold C.

doi:10.20959/wjpps201704-8716

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…[7][8] Extracts from different parts of Newbouldia leavis plant have been extensively studied and reported to possess analgesic, anti-nociceptive, anti-inflammatory, uterine contractile, anti-diabetic, anti-cancer, anticoagulant, antioxidant, antimicrobial, sedative, antimalarial, anti-ulcer, anti-convulsant and depressant activities. [9][10][11][12][13][14][15][16][17]…”

Section: Introductionmentioning

confidence: 99%

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

2023

TJNPR

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This research aimed at evaluating the toxicological profile of ethanol stem-bark extract of N. laevis in Wistar rats. Repeated oral dose toxicity studies (28 and 90 days) were carried out with 32 rats for 28-day study and 40 rats for 90-day study. The rats were divided into 4 groups (A, B, C and D) of six rats per group and were treated with 250, 500 and 1,000 mg/kg body-weight of the extract for 28 and 90 days respectively. Blood samples were collected at the end of the experiment and were used for Biochemical and Haematological investigations, organs were also collected for histological examination. There was significant (p ≤ 0.05) reduction in WBCs following 28-day treatment and a significant (p ≤ 0.05) increase after 90-day treatment. The RBCs, haemoglobin and haematocrit increased significantly (p ≤ 0.05) at 1,000 mg/kg following 28-day treatment and at all doses for RBCs and haemoglobin after 90-day treatment. A significant (p ≤ 0.05) increase in HDL and a decrease in LDL was observed after 28-day treatment, the 90 days treatment showed significant (p ≤ 0.05) decrease in HDL and an increase in LDL. The AST level also increased significantly (p ≤ 0.05) after 28-day treatment. Histological-examination revealed pathological abnormalities in kidney and liver of the treated rats at all doses. This study showed that extract of N. laevis stem-bark was toxic when used at high doses and for a long period of time in the treated rats.

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Section: Introductionmentioning

confidence: 99%

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

2023

TJNPR

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“…Humanity faces different challenges due to the proliferation of diseases caused by organisms found everywhere in the environment. The author [2] opined that using plants to manage and treat diseases is an age-long practice. According to him, it has been found that many plants possess medicinal value, and different parts of these plants have helped synthesise medicines used in hospitals, clinics, and other health care centres.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Acute Toxicity and Analgesic Activity of Extracts From Newbouldia laevis in Laboratory Animals

Peter

Ekene²,

Chiaguguom³

et al. 2022

PoS

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Extraction was by cold maceration using methanol. The extract was concentrated in vacuo to yield a brown solid of 120.191 g. The crude methanol extract was partitioned into n-hexane 0.1 g, dichloromethane 2.5 g, ethylacetate 4.6 g, and methanol 10.0 g fractions via coarse chromatography. Secondary metabolites identified; 21.73±0.36% alkaloids, 40.78±0.27% flavonoids, 15.99±0.044% saponins, 6.088±0.06% tannins, 3.086±0.03% terpenoids and 12.13±0.01% Cardiac Glycosides. Acute toxicity test showed no death in the rats administered with low dose (1000 mg/kg) and high dose (6000 mg/kg). Analgesic activities of crude methanol extract and fractions showed that at a low dose of 4000 mg/kg of the extract and the fractions have percentage inhibition of pains as methanol crude (63.48±4.62), methanol fraction (79.14±7.39), dichloromethane fraction (60.79±6.69), ethylacetate fraction (23.26±9.75) and n-hexane fraction (64.82±9.75). At a high dose of 8000 mg/kg, the percentage inhibition of pain was 5200±2.00, 71.87±7.04, 80.31±6.20, 45.61±12.60 and 43.87±8.13. Statistical analysis; P>0.05 confidence level, methanol fraction recorded highest analgesic activities while ethylacetate fraction had least.

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Antiplasmodial Activity of the Ethanol Leaf Extract of Newbouldia Laevis

Abstract: Malaria is a parasitic protozoan disease caused by the protozoan parasites belonging to the genus Plasmodium. It is a major threat to health and constitutes medical and developmental challenge to

Cited by 2 publications

References 13 publications

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

Phytochemical Screening, Acute Toxicity and Analgesic Activity of Extracts From Newbouldia laevis in Laboratory Animals

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