“…Decreases JAK2/signal transducer and activator of transcription 1 activity, enhances antioxidant capacity and decreases apoptosis (Zhou et al, 2019) Hyperlipidemia combined with MI/R model in male Wistar rats 8, 16, 32 mg•kg -1 i.p. Suppresses the over-expression of TLR4 (Han et al, 2016) H/R and LPS-induced neonatal rat ventricular myocytes 1, 3, 10 mmol•L -1 / Decreases excessive secretion of inflammatory cytokines, down-regulates over-expression of TLR4 and NF-kB (Han et al, 2016) H/R-induced H9c2 cells 6.25, 12.5, 25 mmol•L -1 / Improves cardiomyocyte viability, maintains mitochondrial membrane potential, reduces apoptotic cardiomyocytes, decreases Caspase-3 activity, and inhibits NLRP3 inflammasome activation (Ye et al, 2020) H/R-induced H9c2 cells 1.25, 5, 20 mmol•L -1 / Activates the hexokinase II proteins, restores mitochondrial energy, reduces ROS generation (Min and Wei, 2017) H/R-induced H9c2 cells 20 mmol•L -1 / Inactivates the JAK2/signal transducer and activator of the transcription 1 pathway (Zhou et al, 2019) H/R-induced H9c2 cells 5, 20, 80 mmol•L -1 / Up-regulates HO-1 expression through the PI3K/Akt/Nrf2 signaling pathway (Liu et al, 2012) MI/R model in hearts isolated from male SD rats 50, 100, 200 mmol•L -1 / Enhances NO production by eNOS activation (Liu et al, 2008) H/R-induced cardiomyocytes isolated from SD rat hearts 100, 200 mmol•L -1 / Modulates the reduction of viability and the loss of rodshaped cells, and interacts with the mtPTP (Huber et al, 2018) Hypertension Male spontaneous hypertension rat and normotensive Wistar-Kyoto rats…”