Cardioprotective effect of hydroalcoholic extract of Brazilian red propolis against isoproterenol-induced myocardial infarction in rats

Neto, José Clementino; Paulino, Emanuel Tenório; Rodrigues, Amanda Karine Barros Ferreira; Silva, Jessyka Carolina Galvão da; Bernardino, Alessandro Cesar; Oliveira, José Marcos dos Santos; Nascimento, Ticiano Gomes do; Oliveira, Woodland de Souza; Santos, Josué Carinhanha Caldas; Smaniotto, Salete; Ribeiro, Êurica Adélia Nogueira

doi:10.1016/j.phyplu.2021.100190

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Because of the abundance of these compounds in propolis, it can help treat a variety of cardiovascular diseases. The ability of flavonoids to scavenge free radicals is responsible for all of their therapeutic implications 83 . Propolis also contains caffeic acid and benzyl caffeate, which inhibit the formation of lipid peroxides, and its extract possesses anti-lipid peroxidative properties 83 , 84 .…”

Section: Discussionmentioning

confidence: 99%

“…The ability of flavonoids to scavenge free radicals is responsible for all of their therapeutic implications 83 . Propolis also contains caffeic acid and benzyl caffeate, which inhibit the formation of lipid peroxides, and its extract possesses anti-lipid peroxidative properties 83 , 84 . Another antioxidant biomarker is CAT, which is a peroxidase enzyme that performs a pivotal function in the metabolism of ROS and OS adaptation 85 .…”

Section: Discussionmentioning

confidence: 99%

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Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats

El-Hakam

Laban

El-Din

et al. 2022

Sci Rep

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Hypertension-induced ventricular and vascular remodeling causes myocardial infarction, heart failure, and sudden death. Most available pharmaceutical products used to treat hypertension lead to adverse effects on human health. Limited data is available on apitherapy (bee products) combinations for treatment of hypertension. This study aims to evaluate the antihypertensive effects of combinations of natural apitherapy compounds used in the medical sector to treat a variety of diseases. Rats were assigned into six groups consisting of one control group and five hypertensive groups where hypertension (blood pressure > 140/90) was induced with dexamethasone. One of these groups was used as a hypertension model, while the remaining four hypertensive groups were treated with a propolis, royal jelly, and bee venom combination (PRV) at daily oral doses of 0.5, 1.0, and 2.0 mg/kg, and with losartan 10 mg/kg. The PRV combination at all doses decreased arterial blood pressure below the suboptimal value (p < 0.001), and PRV combination treatment improved dexamethasone-induced-ECG changes. The same treatment decreased angiotensin-II, endothelin-1, and tumor growth factor β serum levels in hypertensive rats. Additionally, PRV combination improved histopathological structure, and decreased serum levels of NF-kB and oxidative stress biomarkers. We concluded that PRV combination therapy may be used as a potential treatment for a variety of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats

El-Hakam

Laban

El-Din

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It has wide-spectrum biological effects due to its rich chemical and mineral content. Studies have shown that it has antibacterial, antioxidant [ 13 ], antiviral [ 10 ], antitumor [ 14 ], immunomodulatory [ 15 ], anti-inflammatory [ 16 ], hepatoprotective [ 17 ], cardioprotective [ 18 ], neuroprotective [ 19 ], antidiabetic [ 20 ], regenerative [ 21 ], anesthetic [ 22 ], antiallergic [ 23 ] and biological effects. Parallel to these activities, its effects on inflammatory diseases such as gingivitis, osteoarthritis, mastitis, rhinitis and asthma were also investigated [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Antiviral, Cytotoxic, Antioxidant Activities, Total Phenolic Profile and Chemical Content of Propolis Samples in Different Colors from Turkiye

et al. 2022

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Propolis is a valuable natural substance obtained by honey bees after being collected from the bark, resin of trees, plant leaves and mixed with their saliva, and has been widely used for various biological activities. The properties of propolis can vary widely by botanical origin, location of the hives and colony population. It is thought that the color of propolis is one of the main factors determining its acceptability and originates from the flower markers, pollen and nectar of some plants and is directly related to its chemical content. It is important to compare and standardize the colors, chemical content and biological activities of propolis in our country, which has a rich endemic plant diversity. Thus, in this study, the color indexes of 39 propolis samples from different locations in Turkiye were determined by Lovibond Tintometer, for the first time. The color index, total phenolic content, cytotoxic and antioxidant activities relationship of propolis and two commercial propolis samples were also investigated by HCA and PCA. Turkish propolis, which is defined by its color indices, chemical contents and many different activity potentials, such as antioxidant, antiviral and cytotoxic activity, will find use in many fields from medicine to cosmetics with this study.

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Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota

Zhang,

Zhao,

Zhao

et al. 2023

Inflammopharmacol

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Cardioprotective effect of hydroalcoholic extract of Brazilian red propolis against isoproterenol-induced myocardial infarction in rats

Cited by 5 publications

References 23 publications

Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats

Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats

Comparative Study of Antiviral, Cytotoxic, Antioxidant Activities, Total Phenolic Profile and Chemical Content of Propolis Samples in Different Colors from Turkiye

Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota

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