Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota

Zhang, Xuemei; Zhao, Ying; Zhao, Xin; Zhang, Ji; Diao, Jiayu; Jia, Shuo; Feng, Panpan; Yu, Penghua; Cheng, Gong

doi:10.1007/s10787-023-01307-9

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…Muribaculaccae was high abundance differential species of Gansu alpine ne wool sheep. Among them, Verrucomicrobia had anti-in ammatory effects and maintained glucose homeostasis in the host microbiota 50 . Kiritimatiellaeota is involved in arginine and fatty acid biosynthetic pathways 51 .…”

Section: Discussionmentioning

confidence: 99%

Differences in intestinal barrier function between Tianhua mutton sheep and Gansu alpine fine wool sheep (Ovis aries)

Li,

Liu,

Duan

et al. 2024

Preprint

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The purpose of this study was to investigate the difference of intestinal barrier function between Tianhua mutton sheep and Gansu alpine fine wool sheep by HE staining, VFA assay and 16S full-length sequencing. The results showed as follows: 1) Compared with Gansu alpine fine wool sheep, Tianhua mutton sheep showed significantly higher villus height, significantly lighter crypt depth and significantly higher ratio of villus to crypt in duodenum and ileum (P-value < 0.05). 2) In both duodenum and jejunum, the contents of acetic acid and total acid were significantly higher in Tianhua mutton sheep than in Gansu alpine fine wool sheep (P-value < 0.05). 3) The overall comparison of the intestinal tract revealed that the Ace index of Tianhua mutton sheep was significantly higher than that of Alpine fine wool sheep (P-value < 0.05). The intestinal flora was able to separate significantly between the two breeds. LEfSe analysis found that Clostridia, Christensenellaceae-R-7-group-bacterium-AC2043 was the high abundance differential species in Tianhua mutton sheep. 4)The dominant flora of the two fine wool sheep were different in the five intestinal segments, but the content of beneficial bacteria of Tianhua mutton sheep was generally higher than that of Gansu alpine fine wool sheep. It can be seen that the intestinal barrier of Tianhua mutton sheep is better than that of Gansu alpine fine wool sheep, and Tianhua mutton sheep has a stronger adaptation to the living conditions of alpine pasture.

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Section: Discussionmentioning

confidence: 99%

Differences in intestinal barrier function between Tianhua mutton sheep and Gansu alpine fine wool sheep (Ovis aries)

Li,

Liu,

Duan

et al. 2024

Preprint

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Danggui Shaoyao San: comprehensive modulation of the microbiota-gut-brain axis for attenuating Alzheimer’s disease-related pathology

He,

Jin,

et al. 2024

Front. Pharmacol.

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Background: Alzheimer’s disease (AD), an age-associated neurodegenerative disorder, currently lacks effective clinical therapeutics. Traditional Chinese Medicine (TCM) holds promising potential in AD treatment, exemplified by Danggui Shaoyao San (DSS), a TCM formulation. The precise therapeutic mechanisms of DSS in AD remain to be fully elucidated. This study aims to uncover the therapeutic efficacy and underlying mechanisms of DSS in AD, employing an integrative approach encompassing gut microbiota and metabolomic analyses.Methods: Thirty Sprague-Dawley (SD) rats were allocated into three groups: Blank Control (Con), AD Model (M), and Danggui Shaoyao San (DSS). AD models were established via bilateral intracerebroventricular injections of streptozotocin (STZ). DSS was orally administered at 24 g·kg−1·d−1 (weight of raw herbal materials) for 14 days. Cognitive functions were evaluated using the Morris Water Maze (MWM) test. Pathological alterations were assessed through hematoxylin and eosin (HE) staining. Bloodstream metabolites were characterized, gut microbiota profiled through 16S rDNA sequencing, and cortical metabolomics analyzed. Hippocampal proinflammatory cytokines (IL-1β, IL-6, TNF-α) were quantified using RT-qPCR, and oxidative stress markers (SOD, CAT, GSH-PX, MDA) in brain tissues were measured with biochemical assays.Results: DSS identified a total of 1,625 bloodstream metabolites, predominantly Benzene derivatives, Carboxylic acids, and Fatty Acyls. DSS significantly improved learning and spatial memory in AD rats and ameliorated cerebral tissue pathology. The formulation enriched the probiotic Ligilactobacillus, modulating metabolites like Ophthalmic acid (OA), Phosphocreatine (PCr), Azacridone A, Inosine, and NAD. DSS regulated Purine and Nicotinate-nicotinamide metabolism, restoring balance in the Candidatus Saccharibacteria-OA interplay and stabilizing gut microbiota-metabolite homeostasis. Additionally, DSS reduced hippocampal IL-1β, IL-6, TNF-α expression, attenuating the inflammatory state. It elevated antioxidative enzymes (SOD, CAT, GSH-PX) while reducing MDA levels, indicating diminished oxidative stress in AD rat brains.Conclusion: DSS addresses AD pathology through multifaceted mechanisms, encompassing gut microbiome regulation, specific metabolite modulation, and the mitigation of inflammation and oxidative stress within the brain. This holistic intervention through the Microbial-Gut-Brain Axis (MGBA) underscores DSS’s potential as an integrative therapeutic agent in combatting AD.

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Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota

Cited by 2 publications

References 46 publications

Differences in intestinal barrier function between Tianhua mutton sheep and Gansu alpine fine wool sheep (Ovis aries)

Differences in intestinal barrier function between Tianhua mutton sheep and Gansu alpine fine wool sheep (Ovis aries)

Danggui Shaoyao San: comprehensive modulation of the microbiota-gut-brain axis for attenuating Alzheimer’s disease-related pathology

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