Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats

Abstract

Objectives:To study the preventive role of curcumin against doxorubicin (Dox)-induced myocardial toxicity in rats.Materials and Methods:Cardiotoxicity was produced by cumulative administration of Dox (15 mg/kg for two weeks). Curcumin (200 mg/kg, po) was administered as pretreatment for two weeks and then for two alternate weeks with Dox. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), biochemical parameters such as aspartate aminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase (ALP), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were monitored after three weeks of last dose.Results:The repeated administration of Dox induced cardiomyopathy associated with an antioxidant deficit and increased level biomarkers. Pretreatment with the curcumin significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH and CPK and biochemical parameters such as AST, ALT and ALP back to normal. Curcumin increased the reduced level of GSH, SOD and CAT and decreased the elevated level of malondialdehyde (MDA) in cardiac tissue.Conclusion:The biochemical and histopathology reports support the cardioprotective effect of curcumin which could be attributed to antioxidant.

Effect of co-administered lopinavir/ritonavir and sulfamethoxazole/trimethoprim on cardiac function and architecture of albino rats

“…23,24 Increase in cardiac MDA level observed in animals treated with LPV/r is consistent with some reported observations. 25 Elevation in cardiac MDA level observed with respect to treatment with these single agents could be attributed to cardiac injury induced by oxidative stress.…”

Effect of Curcumin on Mitochondrial Function of Cardiomyocytes With Doxorubicininduced Oxidative Stress

“…Це жовтий пігмент, отриманий з коренів рослини Curcuma longa, який використову-ється як біологічно активна добавка в терапії атеросклерозу, цукрового діабету, при алер-гічних захворюваннях. Він має протектив-ний ефект при пошкодженнях міокарда [8], впливає на активність цитокінів, ензимів та транскрипційних факторів, пов'язаних із гіпоксією [9], а також зменшує токсичний вплив доксорубіцину на серце, печінку та нирки за рахунок його антиоксидантних властивостей [10][11][12]. Водночас комплексне вивчення протективного ефекту куркуміну на мітохондріальний апарат кардіоміоцитів при застосуванні антрациклінів досі не про-водилося.…”

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

“…It is largely present in fruits, vegetables, aromatic plants, tea, and red wine (Pandey and Rizvi 2009). The use of both CMN and QR has been reported as a therapeutic agent to mitigate various kinds of toxicity including cardiotoxicity (Matouk et al 2013;Swamy et al 2012), nephrotoxicity (Ciftci et al 2012;Nabavi et al 2012), hepatotoxicity (Waseem and Parvez 2013;Sekaran et al 2012), and neurotoxicity (Haleagrahara et al 2013;Yadav et al 2011). Pretreatment with CMN and QR was found to modulate mitochondrial dysfunction in rodents, and its property as an antioxidant is widely held to be responsible for its protective effects in the mitochondria (Carrasco-Pozo et al 2012;Sood et al 2011).…”