Cardioprotective effect of amlodipine in oxidative stress induced by experimental myocardial infarction in rats

Begum, Sudhira; Akhter, Nargis

doi:10.3329/bjp.v2i2.570

Cited by 8 publications

(8 citation statements)

References 15 publications

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“…Drug doses were guided by the literature and adjusted through pilot trials. NAC was given in a dose of 300 mg/kg/day (Abla et al, 2005, Hsieh et al, 2014), amlodipine was given in a dose of 10 mg/kg/day (Begum and Akhter, 2007), lisinopril was given in a dose of 20 mg/kg/day (Albarwani et al, 2015), and allopurinol was given in a dose 50 mg/kg/day (Aldaba-Muruato et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

Mohammed¹,

Messiha²,

Abo-Saif³

2016

Saudi Pharmaceutical Journal

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Section: Methodsmentioning

confidence: 99%

Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

Mohammed¹,

Messiha²,

Abo-Saif³

2016

Saudi Pharmaceutical Journal

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“…Some other investigators demonstrated the cardioprotective effect of amlodipine in oxidative stress induced by experimental myocardial infarction in rats. Here, amlodipine significantly decreased serum AST and LDH levels and protected the myocardium from adrenalin induced myocardial injury [17].…”

Section: Introductionmentioning

confidence: 79%

Cardioprotective effect of Curcuma longa (turmeric) on serum cardiac marker enzymes in isoproterenol induced myocardial infarction in rats

Akhter¹,

Nahar²

2022

World J. Adv. Res. Rev.

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Myocardial infarction is one of the major causes of global premature mortality and morbidity. As a traditional medicine, Curcuma longa have been used to reduce risk of cardiovascular disease. This study was designed to evaluate the cardioprotective effect of Curcuma longa in isoproterenol induced myocardial infarction in rats. Total 28 Wistar albino male rats were divided into BC (base line control group), ISP (isoproterenol treated control group), CLP-ISPT (Curcuma longa pretreated and isoproterenol treated group) and AP-ISPT (amlodipine pretreated and isoproterenol treated group). At the end of experiment, all the rats were sacrificed. Blood samples were collected from the heart. Serum Aspartate Aminotransferase (AST), Lactate Dehydrogenase (LDH) and Creatine Kinase-MB (CK-MB) levels were estimated to assess myocardial injury. The statistical analysis was done by one-way ANOVA, followed by Bonferroni test. In this study, mean serum AST, LDH and CK-MB levels were significantly (P<0.001) higher in ISP than those of BC. Again, mean serum AST (P<0.001), LDH (P<0.01), CK-MB (P<0.05) levels were significantly lower in CLP-ISPT and AP-ISPT than those of ISP group. From the results, it can be concluded that Curcuma longa has cardioprotective effect on isoproterenol induced myocardial infarction in rats.

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“…Our result is in agreement with other investigators findings. Previously (14,15) found significantly elevated biochemical parameters after the inoculation of adrenaline. Our results are also according to (16) that showed a highly significant elevation in the cardiac biomarkers.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Cardioprotective Potential of Hydroalcoholic Peel Extract of Citrullus Colocynthis

Manzoor¹,

Khan²,

Iqbal

et al. 2020

Preprint

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Background and objective: Myocardial infarction is the number one cause of death both in males and females in many developed countries. Citrullus colocynthis is a medicinal plant used for the treatment for asthma, constipation, cough. The current study evaluates the cardioprotective potential of hydroalcoholic peel extract of Citrullus colocynthis against adrenaline-induced myocardial infarction in rabbits.Materials and Methods: Animals were divided into four major groups each group consisting of six rabbits. Group - 1 was given adrenaline 2mg/kg subcutaneously for two successive days. Considerably (p<0.001) accelerated the ALP, AST, ALT, Troponin, CK-MB, LDH, and CRP (p<0.05). Group 2, 3, 4 rabbits pre-treated with the peel extract of C. colocynthis 100mg/kg, 200mg/kg, 300mg/kg respectively orally for 14 successive days and on 14th and 15th-day adrenaline was inoculated considerably improve the impact of adrenaline through lowering the levels of CK-MB, LDH, Troponin, AST, CRP, ALT, and ALP.Results: The myocardial tissues of adrenaline induced group have more necrotic lesions. A slight deteriorating modifications of myocardial tissues usually in cardiac cells structure were observed in the group treated with extract.Conclusion: The out-turn showed the cardioprotective potential of hydroalcoholic peel extract of C. colocynthis in a dose-dependent manner.

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Cardioprotective effect of amlodipine in oxidative stress induced by experimental myocardial infarction in rats

Cited by 8 publications

References 15 publications

Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

Cardioprotective effect of Curcuma longa (turmeric) on serum cardiac marker enzymes in isoproterenol induced myocardial infarction in rats

Evaluation of Cardioprotective Potential of Hydroalcoholic Peel Extract of Citrullus Colocynthis

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