Cardioprotective actions of nisoldipine in postreperfusion myocardial ischemia

The acute effects on left ventricular function of nisoldipine were studied in six patients 56 +/- 12 hours (range 44 to 72 hours) after the onset of uncomplicated acute myocardial infarction. Nisoldipine was administered as a 4.5 micrograms/kg intravenous bolus over 3 minutes followed by an infusion of 0.2 microgram/kg during 60 minutes. Radionuclide angiography and two-dimensional echocardiography were performed before and during infusion with nisoldipine. The left ventricular ejection fraction increased significantly from 38% +/- 10% to 49% +/- 10% (P = 0.028) during nisoldipine infusion. Regional wall motion index was determined both by radionuclide and by two-dimensional echocardiography and showed a significant change during nisoldipine infusion from 1.9 +/- 0.3 to 1.5 +/- 0.3 (p = 0.028, radionuclide angiography) and from 0.7 +/- 0.2 to 0.3 +/- 0.2 (p = 0.043, two dimensional echocardiography). Heart rate increased significantly from 78 +/- 12 min-1 to 92 +/- 13 min-1 (p = 0.028), but mean double product did not change significantly during nisoldipine infusion. It is concluded that nisoldipine significantly improves global and regional left ventricular function in patients shortly after acute myocardial infarction. This beneficial effect may, however, be partially offset by an increase in heart rate. Since mean double product did not change, it is suggested that nisoldipine may improve coronary blood flow in patients with acute myocardial infarction.

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Effect of iloprost on reperfusion-induced arrhythmias and myocardial ion shifts in isolated rat hearts

Tósaki¹,

Koltai²,

Paubert-Braquet³

1990

European Journal of Pharmacology

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Cardioprotective actions of nisoldipine in postreperfusion myocardial ischemia

Cited by 10 publications

References 20 publications

Effects of Dihydropyridine Calcium Antagonists upon Microvascular Function Following Ischemia and Oxidative Stress

Effects of Dihydropyridine Calcium Antagonists upon Microvascular Function Following Ischemia and Oxidative Stress

The acute effects of intravenous nisoldipine on left ventricular function 24 to 72 hours after uncomplicated acute myocardial infarction

Effect of iloprost on reperfusion-induced arrhythmias and myocardial ion shifts in isolated rat hearts

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