Effect of iloprost on reperfusion-induced arrhythmias and myocardial ion shifts in isolated rat hearts

Tósaki, Árpád; Koltai, M.; Paubert-Braquet, Monique

doi:10.1016/0014-2999(90)94097-h

Cited by 13 publications

(11 citation statements)

References 57 publications

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“…The molecules with the ratios larger than unity and with their interferometric data available are actually found to have significant concentration in the CND: HC3N (J = 11-10, 12-11), SO (JN = 32-21), CH3CN (JK = 6K -5K ) (Takano et al 2014), CS (J = 2-1) Takano et al 2014;Tosaki et al 2017). SiO (J = 2-1) , and HCN (J = 1-0) (e.g., Kohno et al 2008).…”

Section: Integrated Intensity Ratios In Ngc 1068 Between Nro 45 M Andmentioning

confidence: 98%

“…Such different distributions are actually found with the high spatial resolution data obtained with interferometers including ALMA. The CO emission is distributed both in the CND and the starburst ring (e.g., Schinnerer et al 2000), but 13 CO and C 18 O show weak emission lines in the CND and mainly distributed in the starburst ring (e.g., Helfer & Blitz 1995;Papadopoulos et al 1996;Takano et al 2014;Tosaki et al 2017). Therefore, the ratios are higher with the small beam of the 45 m telescope than those with the 30 m telescope.…”

Section: Integrated Intensity Ratios Between Isotopic Species (J = 1-0)mentioning

confidence: 98%

“…On the other hand, the molecules with the ratios smaller than unity and with their interferometric data available are found to be distributed mainly in the starburst ring: 12 CO (J = 1-0) (e.g., Schinnerer et al 2000), 13 CO (J = 1-0) and C 18 O (J = 1-0) (e.g., Takano et al 2014;Tosaki et al 2017). C2H (N = 1-0) and CH3OH (JK =2K -1K ) also show the ratios smaller than unity, and these molecular lines are found to be distributed significantly both in the CND and the starburst ring for C2H; Takano et al (2014) and Tosaki et al (2017) for CH3OH). Nakajima et al (2011) has already suggested that C2H (N = 1-0) is insusceptible to AGN or is tracing cold molecular gas rather than the X-ray irradiated hot gas based on their observations toward NGC 1068 and NGC 253 in the early stage of this line survey.…”

Section: Integrated Intensity Ratios In Ngc 1068 Between Nro 45 M Andmentioning

confidence: 99%

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A molecular line survey toward the nearby galaxies NGC 1068, NGC 253, and IC 342 at 3 mm with the Nobeyama 45 m radio telescope: The data

Takano

Nakajima

Kohno

2019

Publications of the Astronomical Society of Japan

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We present observational data of a molecular line survey toward the nearby galaxies NGC 1068, NGC 253, and IC 342 at the wavelengths of 3 mm (∼85-116 GHz) obtained with the Nobeyama 45 m radio telescope. In IC 342 the line survey with high spectral resolution at the 3 mm region was reported for the first time. NGC 1068 is a nearby gas-rich galaxy with X-rays from an active galactic nucleus (AGN), and NGC 253 and IC 342 are nearby gas-rich galaxies with prototypical starbursts. These galaxies are useful to study the impacts of X-rays and ultraviolet radiation on molecular abundances. The survey was carried out with the resulting rms noise level of a few mK (T * A ). As a result we could obtain almost complete data of these galaxies at the 3 mm region: We detected 19-23 molecular species depending on the galaxies including several new detections (e.g., cyclic-C 3 H 2 in IC 342). We found that the intensities of HCN, CN, and HC 3 N relative to 13 CO are significantly strong in NGC 1068 compared to those in NGC 253 and IC 342. On the other hand, CH 3 CCH was not detected in NGC 1068. We obtained these results with the narrow beam (15 ′′ .2-19 ′′ .1) of the 45 m telescope among the single-dish telescopes, and in particular selectively observed the molecular gas close to the circumnuclear disk (CND) in NGC 1068. Our line intensities in NGC 1068 were compared to those obtained with the IRAM 30 m radio telescope already reported. As a result, the intensity ratio of each line was found to have information on the spatial distribution. Our observations obtained the line intensities and stringent constraints on the upper limit for the three galaxies with such narrow beam, and consequently, the data will be a basis for further observations with high spatial resolution.

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Section: Integrated Intensity Ratios In Ngc 1068 Between Nro 45 M Andmentioning

confidence: 98%

Section: Integrated Intensity Ratios Between Isotopic Species (J = 1-0)mentioning

confidence: 98%

Section: Integrated Intensity Ratios In Ngc 1068 Between Nro 45 M Andmentioning

confidence: 99%

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A molecular line survey toward the nearby galaxies NGC 1068, NGC 253, and IC 342 at 3 mm with the Nobeyama 45 m radio telescope: The data

Takano

Nakajima

Kohno

2019

Publications of the Astronomical Society of Japan

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“…The cardioprotective effects of PGI 2 have been ascribed to the opening of mitochondrial K(ATP) channels [22]. It is interesting to note that chronic treatment of normotensive and spontaneously hypertensive rats with iloprost reduced the incidence of reperfusion-induced arrhythmia [38]. In addition, COX-2-derived PGI 2 has been found to mediate not only ischemic preconditioning but also isoflurane- and diazoxide-induced preconditioning in vivo [39].…”

Section: Discussionmentioning

confidence: 99%

Prostanoid Receptors Involved in Regulation of the Beating Rate of Neonatal Rat Cardiomyocytes

et al. 2012

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Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investigated in detail. In our experiments, prostaglandin (PG)F2α and prostanoid FP receptor agonists (fluprostenol, latanoprost and cloprostenol) produced a decrease in the beating rate. Two prostanoid IP receptor agonists (iloprost and beraprost) induced first a marked drop in the beating rate and then definitive abrogation of beating. In contrast, the prostanoid DP receptor agonists (PGD2 and BW245C) and TP receptor agonists (U-46619) produced increases in the beating rate. Sulprostone (a prostanoid EP1 and EP3 receptor agonist) induced marked increases in the beating rate, which were suppressed by SC-19220 (a selective prostanoid EP1 antagonist). Butaprost (a selective prostanoid EP2 receptor agonist), misoprostol (a prostanoid EP2 and EP3 receptor agonist), 11-deoxy-PGE1 (a prostanoid EP2, EP3 and EP4 receptor agonist) did not alter the beating rate. Our results strongly suggest that prostanoid EP1 receptors are involved in positive regulation of the beating rate. Prostanoid EP1 receptor expression was confirmed by western blotting with a selective antibody. Hence, neonatal rat cardiomyocytes express both prostanoid IP and FP receptors (which negatively regulate the spontaneous beating rate) and prostanoid TP, DP1 and EP1 receptors (which positively regulate the spontaneous beating rate).

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“…A larger controlled clinical study is needed to evaluate the clinical effects in humans of a long term treatment with iloprost on life threatening arrhythmias. 1 Recently, subchondral insufficiency fracture of the femoral head (SIF) has been reported as a differential diagnosis in patients suspected of having osteonecrosis. [2][3][4] We describe the clinicopathological features of a patient with SLE with a history of corticosteroid treatment, who developed SIF.…”

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confidence: 99%

Effects of acute administration of iloprost on the cardiac autonomic nervous system and ventricular repolarisation in patients with systemic sclerosis

Guideri¹

2006

Annals of the Rheumatic Diseases

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Effect of iloprost on reperfusion-induced arrhythmias and myocardial ion shifts in isolated rat hearts

Cited by 13 publications

References 57 publications

A molecular line survey toward the nearby galaxies NGC 1068, NGC 253, and IC 342 at 3 mm with the Nobeyama 45 m radio telescope: The data

A molecular line survey toward the nearby galaxies NGC 1068, NGC 253, and IC 342 at 3 mm with the Nobeyama 45 m radio telescope: The data

Prostanoid Receptors Involved in Regulation of the Beating Rate of Neonatal Rat Cardiomyocytes

Effects of acute administration of iloprost on the cardiac autonomic nervous system and ventricular repolarisation in patients with systemic sclerosis

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