Cardioprotective Action of Ginkgo biloba Extract against Sustained β-Adrenergic Stimulation Occurs via Activation of M2/NO Pathway

Mesquita, Thássio; Jesus, Itamar Couto Guedes de; Santos, João Filipe; Almeida, Grace Kelly Melo de; Vasconcelos, Carla M. L. de; Guatimosim, Sílvia; Macedo, Fabrício Nunes; Santos, Robervan Vidal dos; Menezes-Filho, José Evaldo Rodrigues de; Miguel-dos-Santos, Rodrigo; Matos, Paulo Tojal Dantas; Scalzo, Sérgio; Santana‐Filho, Valter Joviniano; Albuquerque‐Júnior, Ricardo Luiz Cavalcanti de; Pereira-Filho, Rose Nely; Lauton-Santos, Sandra

doi:10.3389/fphar.2017.00220

Cited by 28 publications

(19 citation statements)

References 56 publications

(80 reference statements)

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“…This may be the reason that the sperm parameters of rats exposed to cellphone radiation were negatively affected and histopathological damages in the testes increased. It was determined that Egb761 had a protective and therapeutic effect against many types of tissue damage and various diseases (29,43,44). In this case, we also found that Egb761 alleviated the adverse effects of cellphones on testes and semen parameters.…”

supporting

confidence: 52%

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Gevrek¹,

Aydın²,

Ozsoy³

et al. 2017

BLL

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OBJECTIVES: To determine the effects of Egb761 on testicular tissues and semen parameters in rats exposed to cellphone waves. BACKGROUND: EGb761 has antioxidant properties as a free-radical scavenger. Cellphone electromagnetic radiation (EMR) induces oxidative stress in cells. METHODS: Twenty-one Wistar albino male adult rats were divided into three groups (control, experimental, treatment), including seven rats in each. The experimental and treatment groups were exposed to cellphone EMR (0.96 W/kg) for six weeks (4 hrs/day). Egb761 (100 mg/kg/day) was also added to the treatment. Testes, epididymal semen and blood plasma were used for analysis. RESULTS: Exposure to cellular phone radiation resulted in a signifi cant impairment in testicular morphometry and histological structure, reduction of total and motile sperm numbers and plasma testosterone level. Egb761 administration improved testicular damage and led to a marked increase in plasma testosterone levels and total and motile sperm numbers. CONCLUSION: Male reproductive system is susceptible to cellphone radiation. Cellphone waves induce toxic effects in testicular tissues, impair spermatogenesis and cause an imbalance in testosterone hormone levels. Egb761 ameliorated these toxic effects by reversing testicular tissue damage, restoring normal spermatogenesis and hormone levels. This suggests that Egb761 is a potential therapeutic agent against EMR-induced male reproductive toxicity (Tab. 3, Fig. 6, Ref. 45). Text in PDF www.elis.sk.

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supporting

confidence: 52%

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Gevrek¹,

Aydın²,

Ozsoy³

et al. 2017

BLL

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“…These effects were mediated by the upregulation of M 2 receptors and the downregulation of b 1adrenergic receptors. GBE also restored eNOS activity and consequently elevated NO levels (Mesquita et al, 2017). In addition, the anti-hypertensive effects of EGb761 supplementation were documented in hypertensive rats where SBP, DBP, and arterial BP were reduced.…”

Section: In Vivo Preclinical Evaluation Of Ginkgo Bilobamentioning

confidence: 83%

“…VSMC, vascular smooth muscle cell; ECM, extracellular matrix; EC, endothelial cell; NO, nitric oxide; PPARY, peroxisome proliferator-activated receptor-gamma. By decreasing VEGF-A and FGF-2 levels (Kim et al, 1999b;Keum et al, 2003;Park et al, 2005;Persson et al, 2006;Shin Y. et al, 2013;Deng et al, 2017;Singh et al, 2017;Lee et al, 2019a) Gingko By decreasing caspase 3 and pro-apoptotic Bax expression and increasing anti-apoptotic Bcl-2 expression (Akiba et al, 2007;Lin et al, 2007;Mansour et al, 2011;Liu et al, 2013;Liou et al, 2015;Mesquita et al, 2017;Abdel-Zaher et al, 2018;Huang et al, 2018;Chen et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, vasodilatory and antihypertensive properties of GBE can exert cardioprotective benefits (Perez-Vizcaino et al, 2009). In this regard, GBE has exhibited ACE inhibitory activities (Mansour et al, 2011), activation of cholinergic pathways, endothelial health improvement, inhibition of endothelium activation and adhesion (Mesquita et al, 2017), and serum lipid-lowering activities (Liou et al, 2015;Huang et al, 2018) among other reported effects that are beneficial in CVD.…”

Section: Ginkgo Biloba At the Bench: Mechanism Of Action In Cvdsmentioning

confidence: 99%

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Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed. We also endeavor to document the recent studies aimed to dissect the cellular and molecular cardio-protective mechanisms of the four plants, using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the

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“…GbE is used in treatment of nervous system diseases with high inflammatory mediator relations, acute pancreatitis, myocardial and intestinal ischaemia‐reperfusion damage (Mesquita et al., ; Zhang, Wang, Zhang, Han, & Yang, ). In vivo and in vitro studies stated that GbE is a broad‐spectrum free radical scavenger due to the GbE flavonoids scavenge free radicals, decrease lipid peroxidation and increase antioxidant activities (Mohamed & El‐Moneim, ; Tredici, ).…”

Section: Discussionmentioning

confidence: 99%

The ameliorative effects ofGinkgo bilobaon apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion

et al. 2018

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Torsion/detorsion (T/D) induces testicular damages in both germinal epithelial and interstitial tissues. Ginkgo biloba extract (GbE) exerts antioxidant and free radical scavenger. We investigated the effect of GbE on testicular tissues, Leydig and sperm cells in rats injured with T/D. Twenty-eight Wistar albino rats were randomly assigned into four groups (Control, GbE, Treatment: T/D+GbE, T/D). T/D performed to the rats in torsion, treatment received GbE (50 mg/kg) 1 hr before T/D, GbE group received only GbE (50 mg/kg) and control was defined as sham group. After T/D, the testes along with epididymis were removed and processed. LH-R expression, apoptosis, sperm morphology and histopathological damage scores were determined for each group. Testicular T/D caused significant increases in apoptosis and sperm morphology anomaly, and a significant decrease in Johnsen's testicular biopsy scores, LH-R expression of Leydig cell and normal sperm cell count. GbE ameliorated testicular histopathology and caused significant increases in LH-R expression, normal sperm cell count in the treated and particularly GbE group. Consequently, GbE may prevent testicular injury and enhance Leydig and sperm cell activity following both T/D and normal situation owing to its antioxidant, anti-apoptotic, free radical scavenger and anti-inflammatory effects.

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Cardioprotective Action of Ginkgo biloba Extract against Sustained β-Adrenergic Stimulation Occurs via Activation of M2/NO Pathway

Cited by 28 publications

References 56 publications

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

The ameliorative effects ofGinkgo bilobaon apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion

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