Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Abstract

OBJECTIVES: To determine the effects of Egb761 on testicular tissues and semen parameters in rats exposed to cellphone waves. BACKGROUND: EGb761 has antioxidant properties as a free-radical scavenger. Cellphone electromagnetic radiation (EMR) induces oxidative stress in cells. METHODS: Twenty-one Wistar albino male adult rats were divided into three groups (control, experimental, treatment), including seven rats in each. The experimental and treatment groups were exposed to cellphone EMR (0.96 W/kg) for six weeks (4 hrs/day). Egb761 (100 mg/kg/day) was also added to the treatment. Testes, epididymal semen and blood plasma were used for analysis. RESULTS: Exposure to cellular phone radiation resulted in a signifi cant impairment in testicular morphometry and histological structure, reduction of total and motile sperm numbers and plasma testosterone level. Egb761 administration improved testicular damage and led to a marked increase in plasma testosterone levels and total and motile sperm numbers. CONCLUSION: Male reproductive system is susceptible to cellphone radiation. Cellphone waves induce toxic effects in testicular tissues, impair spermatogenesis and cause an imbalance in testosterone hormone levels. Egb761 ameliorated these toxic effects by reversing testicular tissue damage, restoring normal spermatogenesis and hormone levels. This suggests that Egb761 is a potential therapeutic agent against EMR-induced male reproductive toxicity (Tab. 3, Fig. 6, Ref. 45). Text in PDF www.elis.sk.

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

“…The results suggest that EGB761 can be a protective and therapeutic agent against the male reproductive toxicity induced through electromagnetic radiation and through aluminum, besides lessening the alterations caused by ischemia in the testicular tissue, helping to treat the infertility in such cases. [28,67,68] Colorectal cancer The results showed that EGB761 has antitumor activity, and it can help to prevent the progression of the colorectal cancer.…”

“…The same happens after partial hepatectomy, in which the free radicals harm liver regeneration. In addition to those cases, oxidative stress can reduce the total number of moving sperm cells and induce lesions to the myocardium during the heart reperfusion [12,14,[28][29][30]. In all these cases, it is possible to use EGB761 (▶ Table 1).…”

Untitled

“…According to Gevrek et al [28], radiation produced by electromagnetic mobile phones can lead to oxidative stress, being responsible for causing testicular morphometry damages, decreasing the number of moving spermatozoids, and decreasing testosterone levels. This study showed beneficial results after the administration of EGB761 in mice that were subjected to radiationreducing the toxic effects, reverting the damage to the testicular tissue, and restoring spermatogenesis and hormonal levels-suggesting that EGB761 is a protective and therapeutic agent against male reproductive toxicity induced by radiation.…”

Protective effects of Ginkgo biloba L. against natural toxins, chemical toxicities, and radiation: A comprehensive review

“…Gevrek, Aydin, Ozsoy, Aygun, and Bicer () demonstrated that intraperitoneal injection of 100 mg/kg/day of EGb761 reversed high testicular apoptotic index and the testis histomorphological changes and disturbances related to animal fertility, such as decreased sperm numbers and testosterone hormone level induced by cell phone electromagnetic radiation (0.96 W/kg for six weeks and 4 hr/day; Gevrek et al, ). Another study showed that long‐term exposure of rats' brain to the cell phone radiofrequency increased cell apoptotic markers in the hippocampus region and GB decreased cell mortality (Gevrek, ).…”

“…Gevrek, Aydin, Ozsoy, Aygun, and Bicer (2017) Gevrek et al, 2017). Another study showed that long-term exposure of rats' brain to the cell phone radiofrequency increased cell apoptotic markers in the hippocampus region and GB decreased cell mortality (Gevrek, 2018).…”