Cardiometabolic Syndrome and Increased Risk of Heart Failure

Abstract

Approximately 50 % of patients with heart failure have diastolic heart failure (HFPEF) with the major predisposing risk factors age, inactivity, obesity, insulin resistance (IR), type-2 diabetes, and hypertension. The prognosis of HFPEF is comparable to that of systolic heart failure, but without any specific or effective treatment. This review presents a biomathematically corrected diagnostic approach for quantification of diastolic dysfunction (DD) via the age dependency of diastolic function. Pathophysiological mechanisms for DD in the cardiometabolic syndrome (CMS) are mainly based on downstream effects of IR including insufficient myocardial energy supply. The second section discusses therapeutic strategies for the control and therapy of CMS, IR, and the associated DD/HFPEF with a focus on dietary therapy that is independent of weight loss but improves all manifestations of the CMS and reduces cardiovascular risk.

Prevalence of hyperuricemia in Sukkur; Pakistan: A cross sectional survey.

“…14 This trend that indicates high prevalence of hyperuricemia can be attributed to increasing age which means increase number of years with chronic diseases like hypertension and diabetes. 15 Other reasons for this increase prevalence of hyperuricemia in developing country such as India and Pakistan may be recent changes in diet, a sedentary lifestyle, antihypertensive medications mainly diuretics. 16,17…”

Comorbidities in Practice. Clinical Guidelines

“…Урбанизация приводит к нездоровому образу жизни за счет увеличения употребления табака и алкоголя, продуктов с высоким солевым компонентом, повышенным содержанием жиров в продуктах питания, а также снижения физической активности. Урбанизация поощряет переход от тра-диционной кулинарии к готовым и обработанным пищевым продуктам, которые часто содержат много калорий, соли и жира [64].…”

“…По этой причине в международной классификации болезней 10-го пересмотра такого диагноза нет. Вместе с тем, в реальной клинической практике и научных иссле-дованиях во всем мире данный термин по-преж-нему широко используется (таблица 2) [64].…”