Cardiogenic shock after primary percutaneous coronary intervention: Effects of levosimendan compared with dobutamine on haemodynamics

García-González, Martín J.; Domínguez‐Rodríguez, Alberto; Ferrer-Hita, Julio J.; Abreu-González, Pedro; Muñoz, Miguel Bethencourt

doi:10.1016/j.ejheart.2006.01.007

Cited by 79 publications

(62 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Levosimendan has been recommended for short-term treatment of acute decompensated heart failure (HF) [4]. Recently, we have showed that levosimendan treatment extended its short-term effectiveness on haemodynamics in CS complicating STEMI revascularized by primary angioplasty (PCI) [5]. Nevertheless, information about its effect on long-term outcome is scarce.…”

Section: Introductionmentioning

confidence: 99%

Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty

Samimi-Fard

García-González

Domínguez‐Rodríguez

et al. 2008

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty

Samimi-Fard

García-González

Domínguez‐Rodríguez

et al. 2008

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

“…In an updated meta‐analysis comprising six trials, we found no statistically significant difference in short‐term mortality,27, 28, 29, 30, 31, 32 long‐term mortality,27, 30, 31, 33, 34, 35 ischemic events,30, 34 acute kidney injury,31 dysrhythmias,30, 36 or hospital length‐of‐stay37 in patients with cardiogenic shock treated with dobutamine vs. levosimendan (Fig. 3, Fig.…”

Section: Resultsmentioning

confidence: 94%

Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure

Møller

Granholm

Junttila

et al. 2018

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

BackgroundAdult critically ill patients often suffer from acute circulatory failure and those with low cardiac output may be treated with inotropic agents. The aim of this Scandinavian Society of Anaesthesiology and Intensive Care Medicine guideline was to present patient‐important treatment recommendations on this topic.MethodsThis guideline was developed according to GRADE. We assessed the following subpopulations of patients with shock: (1) shock in general, (2) septic shock, (3) cardiogenic shock, (4) hypovolemic shock, (5) shock after cardiac surgery, and (6) other types of shock, including vasodilatory shock. We assessed patient‐important outcome measures, including mortality and serious adverse reactions.ResultsFor all patients, we suggest against the routine use of any inotropic agent, including dobutamine, as compared to placebo/no treatment (very low quality of evidence). For patients with shock in general, and in those with septic and other types of shock, we suggest using dobutamine rather than levosimendan or epinephrine (very low quality of evidence). For patients with cardiogenic shock and in those with shock after cardiac surgery, we suggest using dobutamine rather than milrinone (very low quality of evidence). For the other clinical questions, we refrained from giving any recommendations or suggestions.ConclusionsWe suggest against the routine use of any inotropic agent in adult patients with shock. If used, we suggest using dobutamine rather than other inotropic agents for the majority of patients, however, the quality of evidence was very low, implying high uncertainty on the balance between the benefits and harms of inotropic agents.

show abstract

“…In a small randomized controlled trial of patients with or without cardiogenic shock after acute myocardial infarction and revascularization, levosimendan significantly improved hemodynamics and coronary flow reserve compared with placebo or dobutamine. 67,68 Severe hyperglycemia worsens outcomes in critically ill patients. In diabetic and nondiabetic patients with acute coronary syndrome, hyperglycemia was associated with cardiovascular complications and increased incidence of mortality, effects consistently seen in the setting of PCI.…”

Section: Management: Pharmacologic Approachesmentioning

confidence: 99%

How Does One Diagnose and Manage Acute Myocardial Ischemia in the Intensive Care Unit?

Zafirova¹,

Moitra²,

Ellis³

2010

Evidence-Based Practice of Critical Care

View full text Add to dashboard Cite

Cardiogenic shock after primary percutaneous coronary intervention: Effects of levosimendan compared with dobutamine on haemodynamics

Abstract: The primary objective of our study was achieved better by the end of the 24 h infusion of levosimendan than by dobutamine.

Cited by 79 publications

References 28 publications

Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty

Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty

Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure

How Does One Diagnose and Manage Acute Myocardial Ischemia in the Intensive Care Unit?

Contact Info

Product

Resources

About