Cardioembolic stroke

Murtagh, Blaithnead; Smalling, Richard W.

doi:10.1007/s11883-006-0009-9

Cited by 84 publications

(76 citation statements)

References 54 publications

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“…Cardioembolic strokes usually have more severe clinical status and a higher risk of recurrence in the short term compared to other stroke groups (13,14). Echocardiography serves as the cornerstone in evaluating patients who may have had a cardioembolic stroke (15).…”

Section: Discussionmentioning

confidence: 99%

Left atrial dilatation in undetermined group according to TOAST classification: echocardiographic assessment of stroke patients

Takoğlu¹,

Can²

2013

Turk J Med Sci

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Th is paper presents the author's integrated regional studies during the last decade. Th e main purpose is to present an overall understanding of the geological structure, sedimentary basins and hydrocarbon systems of the whole Western Black Sea Zone (WBSZ). Th is study is based on original data from boreholes, seismic and gravity-magnetic surveys and hydrocarbon accumulations.Many geophysical borehole data obtained for WBSZ during the last 3-4 decades were interpreted mostly at a national level using diff erent approaches, terminology and nomenclature for the same or similar lithostratigraphic and tectonic units. Th erefore, a unifi ed approach to interpretation of borehole-seismic data and correlation of stratigraphic, sedimentological and tectonic units has a key importance for overall clarifi cation of the deep geological structure and the hydrocarbon challenges.A set of regional geological cross-sections along good quality basic seismic lines and basic boreholes was constructed. A detailed tectonic map of the WBSZ has been compiled by integrated interpretation of seismic borehole and gravitymagnetic data. Th e defi nition of hydrocarbon systems and promising exploration trends is made by source rock assessment, Oil-Oil and Oil-Source rock correlations, analyses of the reservoir/seal pairs and the hydrocarbon migration and accumulation. Genetic correlations are based on many Rock-Eval, Gas Chromatography/Mass Spectrometry (GC-MS) and carbon isotope analyses.Th e complex geological structure of the WBSZ is defi ned by four groups of tectonic units: (1) Western Black Sea basin (WBSB) -its western zone with the Kamchia and the Histria westward wedging branches (sub-basins); ( 2) portions of the Moesian, Scythian and East European platforms; (3) fragments of the North Dobrogea, Eastern Balkan, Eastern Srednogorie and Strandzha orogens; (4) Burgas and Babadag basins.Four diff erent oil genetic types have been identifi ed. Th ree main hydrocarbon systems with economic potential are defi ned, they relate to: WBSB and its Histria and Kamchia branches, the East-Varna trough and the Bourgas basin. Conceptual models for hydrocarbon systems and their prospect exploration trends are constructed.

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Section: Discussionmentioning

confidence: 99%

Left atrial dilatation in undetermined group according to TOAST classification: echocardiographic assessment of stroke patients

Takoğlu¹,

Can²

2013

Turk J Med Sci

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“…25,26,28,29 Moreover, CES is generally severe, reflected by greater disability, greater rates of stroke recurrence, and greater mortality than in other subtypes of strokes. 24,30 Prior knowledge of a diagnosis of AF and appropriate anticoagulation is therefore important to reduce the risk for stroke in such patients. Clinical trials on stroke prevention in patients with AF have shown that anticoagulation with warfarin reduces the risk for stroke substantially 25,31 and is more effective than therapy with antiplatelet agents such as aspirin and clopidogrel.…”

Section: Discussionmentioning

confidence: 99%

Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke

Grétarsdóttir¹,

Þorleifsson²,

Manolescu³

et al. 2008

Annals of Neurology

257

184

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We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES. The association with noncardiogenic stroke is intriguing and suggests that atrial fibrillation may be underdiagnosed in patients presenting with stroke. This discovery may have implications for workup and treatment of IS.

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“…Cardiovascular disease is associated with at least a fivefold increased incidence of stroke [34], with embolism of cardiac origin accounting for over one-fifth of all ischemic strokes [3,19]. The incidence of first-ever cardioembolic stroke is estimated to be 30 per 100,000 population [15], Stroke due to cardioembolism is also associated with a higher mortality and carries the risk of early and long-term recurrence [9,10]; consequently, it is a significant health-care challenge.…”

Section: Introductionmentioning

confidence: 99%

“…The epidemiology and clinical features of cardioembolic stoke have been investigated in several studies [3,10,15,19]. Health-economic evaluations, however, on this important clinical condition are scarce.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of costs and outcome in cardioembolic stroke or TIA

et al. 2009

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The costs of acute stroke care, length of hospital stay (LOS), and outcome in patients with cardioembolic stroke or cardioembolic transient ischemic attacks (TIA) were investigated with the aim of estimating the clinical and health-economic impacts of cerebral cardioembolism. The study population consisted of 511 consecutive patients with the diagnosis of ischemic stroke (n = 379) or TIA (n = 132) treated at the Department of Neurology, Philipps University, Marburg. Cerebral cardioembolism was defined according to the criteria of the Cerebral Embolism Task Force. Clinical status was assessed by means of Barthel index (BI) and modified Rankin Scale. Costs were calculated using a bottom-up approach. All costs (in Euros) were inflated to the 2008 level. Compared to non-cardioembolic stroke (n = 278) patients, patients who had suffered cardioembolic stroke (n = 101) had more severe clinical deficits on admission (BI 46.3 +/- 27.0 vs. 59.3 +/- 34.1; P < 0.01), worse recovery (BI on discharge 59.2 +/- 28.9 vs. 73.1 +/- 33.4; P < 0.01), and increased LOS (12.6 +/- 5.7 vs. 10.0 +/- 7.8 days; P < 0.01). The latter also required a relatively higher daily resource utilization due to increased expenses for personnel and diagnostics. Mean costs of acute care for patients with cardioembolic stroke [euro 4890 per patient (95% confidence interval 4460-5200)] were significantly higher than those for patients with non-cardioembolic stroke [euro 3550 (95% confidence interval 3250-3850); P < 0.01]. The clinical and health-economic impact of cardiogenic cerebral embolism on stroke care is considerable. Patients with cardioembolic stroke/TIA are more severely impaired, and they require longer hospital treatment and increased resource utilization. Costs of acute care of cardioembolic stroke/TIA patients may exceed those of non-cardioembolic stroke/TIA by up to 40%.

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Cardioembolic stroke

Cited by 84 publications

References 54 publications

Left atrial dilatation in undetermined group according to TOAST classification: echocardiographic assessment of stroke patients

Left atrial dilatation in undetermined group according to TOAST classification: echocardiographic assessment of stroke patients

Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke

Evaluation of costs and outcome in cardioembolic stroke or TIA

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