Cardio-supportive devices (VRD &amp; DCC device) and patches for advanced heart failure: A review, summary of state of the art and future directions

Naveed, Muhammad; Han, Lei; Khan, Ghulam Jilany; Yasmeen, Sufia; Mikrani, Reyaj; Abbas, Muhammad; Li, Cunyu; Zhou, Xiaohui

doi:10.1016/j.biopha.2018.03.049

Cited by 23 publications

(17 citation statements)

References 106 publications

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“…The medical mesh implanted for 14 d endured a pull‐off force of 2.27 N, as compared to 0.91 N for a silicon implant. The first soft robotic device (CorInnova Inc., USA) that can be delivered by a minimally invasive method through a delivery tube was designed (Figure i) . The pneumatic driver inside the device conforms to the heart without sutures and compresses the heart in synchrony with the native heart rhythm.…”

Section: Soft Bioelectronics–assisted Therapymentioning

confidence: 99%

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Hong

Jeong

Cho

et al. 2019

Adv Funct Materials

395

271

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Cardiovascular disease is the leading cause of death and has dramatically increased in recent years. Continuous cardiac monitoring is particularly important for early diagnosis and prevention, and flexible and stretchable electronic devices have emerged as effective tools for this purpose. Their thin, soft, and deformable features allow intimate and long-term integration with biotissues, which enables continuous, high-fidelity, and sometimes large-area cardiac monitoring on the skin and/or heart surface. In addition to monitoring, intimate contact is also crucial for high-precision therapies. Combined with tissue engineering, soft bioelectronics have also demonstrated the capability to repair damaged cardiac tissues. This review highlights the recent advances in wearable and implantable devices based on flexible and stretchable electronics for cardiovascular monitoring and therapy. First, wearable/implantable soft bioelectronics for cardiovascular monitoring (e.g., the electrocardiogram, blood pressure, and oxygen saturation level) are reviewed. Then, advances in cardiovascular therapy based on soft bioelectronics (e.g., mesh pacing, ablation, robotic sleeves, and electronic stents) are discussed. Finally, device-assisted tissue engineering therapy (e.g., functional electronic scaffolds and in vitro cardiac platforms) is discussed.

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Section: Soft Bioelectronics–assisted Therapymentioning

confidence: 99%

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Hong

Jeong

Cho

et al. 2019

Adv Funct Materials

395

271

View full text Add to dashboard Cite

show abstract

“…Active hydraulic ventricular attaching support system (ASD) is a net cover made of silicone a biocompatible material with a heart-shaped configuration consisting of flexible interconnected hollow tubules; it is surgically fixed to the outer wall of the heart and covers both ventricles of the heart providing physical support [18]. ASD is manufactured as previously described method [19,20]. Briefly, the 3D printed wax model of ASD was made at first, and covered it with silicone evenly, then heated it at 100 • C for one hour to melt the wax and obtain the pure silicone ASD (Fig.…”

Section: Designing and Manufacturing Of Asdmentioning

confidence: 99%

Therapeutic approach for global myocardial injury using bone marrow-derived mesenchymal stem cells by cardiac support device in rats

Liu

Naveed

Mikrani

et al. 2021

Biomed Microdevices

Self Cite

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Bone marrow-derived mesenchymal stem cells (BMSCs) have been considered a promising therapeutic approach to cardiovascular disease. This study intends to compare the effect of BMSCs through a standard active cardiac support device (ASD) and intravenous injection on global myocardial injury induced by isoproterenol. BMSCs were cultured in vitro, and the transplanted cells were labeled with a fluorescent dye CM-Dil. Isoproterenol (ISO) was injected into the rats; two weeks later, the labeled cells were transplanted into ISO-induced heart injury rats through the tail vein and ASD device for five days. The rats were sacrificed on the first day, the third day, and the fifth day after transplantation to observe the distribution of cells in the myocardium by fluorescence microscopy. The hemodynamic indexes of the left ventricle were measured before sacrificing. H&E staining and Masson's trichrome staining were used to evaluate the cardiac histopathology. In the ASD groups, after three days of transplantation, there were a large number of BMSCs on the epicardial surface, and after five days of transplantation, BMSCs were widely distributed in the ventricular muscle. But in the intravenous injection group, there were no labeled-BMSCs distributed. In the ASD+BMSCs-three days treated group and ASD+BMSCs -five days-treated group, left ventricular systolic pressure (LVSP), maximum rate

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“…In addition to mechanical reinforcement of the myocardium, patches may also be engineered to serve as a cellular substrate (i.e., engineered ECM) to recruit and retain cell types involved in native myocardial regeneration and angiogenesis ( Serpooshan et al, 2013 ). Building on these techniques, scaffolds can serve as vehicles to deliver therapeutic cytokines, growth factors, proteins, and stem cells to the affected areas ( Naveed et al, 2018 ).…”

Section: Tissue Engineered Solutionsmentioning

confidence: 99%

The Expanding Armamentarium of Innovative Bioengineered Strategies to Augment Cardiovascular Repair and Regeneration

Elde

Wang

Woo

2021

Front. Bioeng. Biotechnol.

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Cardiovascular disease remains the leading cause of death worldwide. While clinical trials of cell therapy have demonstrated largely neutral results, recent investigations into the mechanisms of natural myocardial regeneration have demonstrated promising new intersections between molecular, cellular, tissue, biomaterial, and biomechanical engineering solutions. New insight into the crucial role of inflammation in natural regenerative processes may explain why previous efforts have yielded only modest degrees of regeneration. Furthermore, the new understanding of the interdependent relationship of inflammation and myocardial regeneration have catalyzed the emergence of promising new areas of investigation at the intersection of many fields.

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Cardio-supportive devices (VRD & DCC device) and patches for advanced heart failure: A review, summary of state of the art and future directions

Cited by 23 publications

References 106 publications

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Therapeutic approach for global myocardial injury using bone marrow-derived mesenchymal stem cells by cardiac support device in rats

The Expanding Armamentarium of Innovative Bioengineered Strategies to Augment Cardiovascular Repair and Regeneration

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