Cardio-Pulmonary Interactions at High Altitude

Maggiorini, Marco

doi:10.1007/978-1-4419-8997-0_13

Cited by 16 publications

(1 citation statement)

References 39 publications

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“…VD3 treatment significantly reduced K + and Na + concentrations and ultimately maintained electrolyte homeostasis. Patients with lung injury caused by hyperbaric hypoxia may also present with generalized edema and pleural-pericardial effusion, and the resulting heart failure may be the cause of elevated K + and Na + levels [ 35 , 36 ]. Similarly, a previous study showed that Compared with controls, patients with lung injury caused by hyperbaric hypoxia had significantly higher serum Na + and K + [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 improved hypoxia-induced lung injury by inhibiting the complement and coagulation cascade and autophagy pathway

Dai,

Lin,

et al. 2024

BMC Pulm Med

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Background Pulmonary metabolic dysfunction can cause lung tissue injury. There is still no ideal drug to protect against hypoxia-induced lung injury, therefore, the development of new drugs to prevent and treat hypoxia-induced lung injury is urgently needed. We aimed to explore the ameliorative effects and molecular mechanisms of vitamin D3 (VD3) on hypoxia-induced lung tissue injury. Methods Sprague–Dawley (SD) rats were randomly divided into three groups: normoxia, hypoxia, and hypoxia + VD3. The rat model of hypoxia was established by placing the rats in a hypobaric chamber. The degree of lung injury was determined using hematoxylin and eosin (H&E) staining, lung water content, and lung permeability index. Transcriptome data were subjected to differential gene expression and pathway analyses. In vitro, type II alveolar epithelial cells were co-cultured with hepatocytes and then exposed to hypoxic conditions for 24 h. For VD3 treatment, the cells were treated with low and high concentrations of VD3. Results Transcriptome and KEGG analyses revealed that VD3 affects the complement and coagulation cascade pathways in hypoxia-induced rats, and the genes enriched in this pathway were Fgb/Fga/LOC100910418. Hypoxia can cause increases in lung edema, inflammation, and lung permeability disruption, which are attenuated by VD3 treatment. VD3 weakened the complement and coagulation cascade in the lung and liver of hypoxia-induced rats, characterized by lower expression of fibrinogen alpha chain (Fga), fibrinogen beta chain (Fgb), protease-activated receptor 1 (PAR1), protease-activated receptor 3 (PAR3), protease-activated receptor 4 (PAR4), complement (C) 3, C3a, and C5. In addition, VD3 improved hypoxic-induced type II alveolar epithelial cell damage and inflammation by inhibiting the complement and coagulation cascades. Furthermore, VD3 inhibited hypoxia-induced autophagy in vivo and in vitro, which was abolished by the mitophagy inducer, carbonyl cyanide-m-chlorophenylhydrazone (CCCP). Conclusion VD3 alleviated hypoxia-induced pulmonary edema by inhibiting the complement and coagulation cascades and autophagy pathways.

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Section: Discussionmentioning

confidence: 99%

Vitamin D3 improved hypoxia-induced lung injury by inhibiting the complement and coagulation cascade and autophagy pathway

Dai,

Lin,

et al. 2024

BMC Pulm Med

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Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness

Rimoldi

Rexhaj

Villena

et al. 2016

Advances in Experimental Medicine and Biology

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Studies of high-altitude populations, and in particular of maladapted subgroups, may provide important insight into underlying mechanisms involved in the pathogenesis of hypoxemia-related disease in general. Chronic mountain sickness (CMS) is a major public health problem in mountainous regions of the world affecting many millions of high-altitude dwellers. It is characterized by exaggerated chronic hypoxemia, erythrocytosis, and mild pulmonary hypertension. In later stages these patients often present with right heart failure and are predisposed to systemic cardiovascular disease, but the underlying mechanisms are poorly understood. Here, we present recent new data providing insight into underlying mechanisms that may cause these complications.

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Das Respiratorische System auf großer Höhe: Pathophysiologie und neue Therapieoptionen

Trübsbach

Pircher

Treml

et al. 2011

Wien Klin Wochenschr

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Cardio-Pulmonary Interactions at High Altitude

Cited by 16 publications

References 39 publications

Vitamin D3 improved hypoxia-induced lung injury by inhibiting the complement and coagulation cascade and autophagy pathway

Vitamin D3 improved hypoxia-induced lung injury by inhibiting the complement and coagulation cascade and autophagy pathway

Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness

Das Respiratorische System auf großer Höhe: Pathophysiologie und neue Therapieoptionen

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