Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness

Rimoldi, Stefano F.; Rexhaj, Emrush; Villena, Mercedes; Salmòn, Carlos Salinas; Allemann, Yves; Scherrer, Urs; Sartori, Cláudio

doi:10.1007/978-1-4899-7678-9_6

Cited by 2 publications

(2 citation statements)

References 75 publications

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“…The reduced capacity for responding to α-adrenergic stimulation after hypoxia acclimation in lowland white-footed mice could reflect a plastic vascular response resulting from chronic activation of the hypoxic chemoreflex. The hypoxic chemoreflex, initiated when the carotid bodies detect low arterial O 2 levels, leads to sympathoadrenal activation, and the resulting α-mediated vasoconstriction can increase vascular resistance, restrict blood flow to some tissues, and induce systemic hypertension ( Calbet, 2003 ; Hainsworth and Drinkhill, 2007 ; Hainsworth et al, 2007 ; Richalet, 2016 ; Rimoldi et al, 2016 ; Sander, 2016 ). The observed response of lowland white-footed mice to chronic hypoxia should help attenuate these effects by reducing the responsiveness of the systemic vasculature to catecholamines.…”

Section: Discussionmentioning

confidence: 99%

Adrenergic control of the cardiovascular system in deer mice native to high altitude

Wearing

Nelson

Ivy

et al. 2022

Current Research in Physiology

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Studies of animals native to high altitude can provide valuable insight into physiological mechanisms and evolution of performance in challenging environments. We investigated how mechanisms controlling cardiovascular function may have evolved in deer mice ( Peromyscus maniculatus ) native to high altitude. High-altitude deer mice and low-altitude white-footed mice ( P. leucopus ) were bred in captivity at sea level, and first-generation lab progeny were raised to adulthood and acclimated to normoxia or hypoxia. We then used pharmacological agents to examine the capacity for adrenergic receptor stimulation to modulate heart rate ( f H ) and mean arterial pressure ( P mean ) in anaesthetized mice, and used cardiac pressure-volume catheters to evaluate the contractility of the left ventricle. We found that highlanders had a consistently greater capacity to increase f H via pharmacological stimulation of β 1 -adrenergic receptors than lowlanders. Also, whereas hypoxia acclimation reduced the capacity for increasing P mean in response to α-adrenergic stimulation in lowlanders, highlanders exhibited no plasticity in this capacity. These differences in highlanders may help augment cardiac output during locomotion or cold stress, and may preserve their capacity for α-mediated vasoconstriction to more effectively redistribute blood flow to active tissues. Highlanders did not exhibit any differences in some measures of cardiac contractility (maximum pressure derivative, d P /dt max , or end-systolic elastance, E es ), but ejection fraction was highest in highlanders after hypoxia acclimation. Overall, our results suggest that evolved changes in sensitivity to adrenergic stimulation of cardiovascular function may help deer mice cope with the cold and hypoxic conditions at high altitude.

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Section: Discussionmentioning

confidence: 99%

Adrenergic control of the cardiovascular system in deer mice native to high altitude

Wearing

Nelson

Ivy

et al. 2022

Current Research in Physiology

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“…Chronic mountain sickness (CMS) is a common and frequently occurring disease that threatens the population living on the high-altitude plateau. CMS can cause damage to multiple organs, especially the brain and heart 1 . Brain damage, such as cerebral edema, and neurological deterioration could be related to the structural changes of the white matter fibre bundle, microstructural changes within the gray matter, and cognitive function changes.…”

Section: Introductionmentioning

confidence: 99%

DTI Study on Brain Structure and Cognitive Function in Patients with Chronic Mountain Sickness

Bao

et al. 2019

Sci Rep

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In chronic mountain sickness (CMS) patients, the structure of the brain, memory and cognition are often irreversibly damaged by chronic hypoxia due to red blood cell overcompensation, elevated haemoglobin and blood stasis. In this study, we aimed to evaluate this damage using diffusion tensor imaging (DTI) and to study the correlations among the fractional anisotropy (FA),the apparent diffusion coefficient (ADC) value, the severity index of CMS and the simple Mental State Examination (MMSE) score in CMS patients. A total of 17 patients with CMS and 15 healthy controls were recruited for conventional brain magnetic resonance imaging (MRI) and DTI scans, and ADC images were reconstructed along with FA and FA colour maps. The FA and ADC values of the selected regions of interest (ROIs) were measured and compared. The FA and ADC values were also compared with the haemoglobin (Hb) and MMSE scores. CMS patients are prone to intracranial ischaemia, infarction and haemorrhage. Multiple structural changes occur in the brain of CMS patients, and these changes are related to the severity of the disease and cognitive function variation. The white matter fibre bundles of CMS patients showed no obvious damage, except in the ischaemic site.

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Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness

Cited by 2 publications

References 75 publications

Adrenergic control of the cardiovascular system in deer mice native to high altitude

Adrenergic control of the cardiovascular system in deer mice native to high altitude

DTI Study on Brain Structure and Cognitive Function in Patients with Chronic Mountain Sickness

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