Cardio-Protective Effects of Germinated Brown Rice Extract Against Myocardial Ischemia Reperfusion Injury

Petchdee, Soontaree; Laosripaiboon, Wanpen; Jarussophon, Nongpanga; Kumphune, Sarawut

doi:10.1007/s40292-020-00378-x

Cited by 6 publications

(8 citation statements)

References 23 publications

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“…The cardioprotective effect of GBR has been revealed in a previous study. 21 , 22 However, the effect of GBR treatment combined with cardioplegic solution has not been explored yet. To investigate whether the combination of GBR and cardioplegic solution protected against sI/R injury, cell viability of primary porcine cardiomyocytes cultured in experimental conditions for 72 hours were determined by MTT assay.…”

Section: Resultsmentioning

confidence: 99%

“…Bio-functional foods, especially GBR, have gained extensive attention due to their health-enhancing properties. 13,[15][16][17][18][19][20][21][22][23] However, a few previous studies prosperously published the potential effects of GBR on cardiac protection, including anti-inflammation, anti-oxidant, and anti-arrhythmia. [21][22][23] They found that GBR demonstrated the cardio-protective effects against ischemic-reperfusion injury both in vitro and in vivo experiment from chronic myocardial injury.…”

Section: Discussionmentioning

confidence: 99%

“…13,[15][16][17][18][19][20][21][22][23] However, a few previous studies prosperously published the potential effects of GBR on cardiac protection, including anti-inflammation, anti-oxidant, and anti-arrhythmia. [21][22][23] They found that GBR demonstrated the cardio-protective effects against ischemic-reperfusion injury both in vitro and in vivo experiment from chronic myocardial injury. A study in H9c2 cells revealed that GBR exerted its cardioprotective effects by preserving mitochondria function regarding mitochondria membrane potential and mitochondria respiration.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, there were several bioactive compounds of GBR that assisted the health-advantage activities. 15,22 The significant active substrates of GBR extract have been demonstrated as anti-inflammatory, anti-arrhythmia, antidiabetic properties, anti-obesity, and anti-oxidant. [13][14][15][16][17][18][19][20][21]32 It seems that the anti-inflammatory effect of GBR is due to enrichment of flavonoid and phenolic compound contents.…”

Section: Discussionmentioning

confidence: 99%

“…The possible mechanism is the activation of p38 MAPK and downstream of proapoptotic Bax and Bcl-2, and caspase-3 protein expression. 21 , 22 Recently, a study in H9c2 cardiomyocytes subjected to simulated ischemic reperfusion injury has documented a protective property of GBR via ameliorated mitochondria dysfunction by maintaining mitochondrial membrane potential and preserving mitochondrial respiration. 23 Accumulating indicated that GBR might preserve the cardiomyocytes’ function from ischemic reperfusion injury in an experimental model.…”

Section: Introductionmentioning

confidence: 99%

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A Cardiac Protection of Germinated Brown Rice During Cardiopulmonary Bypass Surgery and Simulated Myocardial Ischemia

Demeekul¹,

Sukumolanan²,

Bootcha³

et al. 2021

JIR

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The potential cardio-protective property of germinated brown rice (GBR) has been revealed by ameliorating risk factors related to cardiovascular diseases. This study hypothesized that the combination of GBR and cardioplegic solution could protect the cardiomyocytes exposed to simulated ischemic reperfusion injury in vitro study and preserve cardiac function during cardiopulmonary bypass surgery in animal models. Methods: Primary porcine cardiomyocytes were isolated and experimented cell viability against simulated ischemic reperfusion injury. In a cardiac surgical animal model, six pigs were randomly assigned to receive the two types of cardioplegic solution: i) St. Thomas cardioplegic solution (20 cc/kg); and ii) St. Thomas cardioplegic solution plus GBR (1 mg/ kg). During open-heart surgery, the aorta was cross-clamped for 20 minutes, followed by reperfusion for 1 hour. Cardiopulmonary bypass parameters were recorded until the end of the procedure. Furthermore, hemodynamic parameters and arterial blood gas characteristics of animals among groups were monitored at different time points, including baseline before cardiopulmonary bypass (T1), during cardiopulmonary bypass (T2), during aortic clamp on (T3), and aortic clamp off (T4). Results: Primarily, GBR cotreatment with cardioplegic solution essentially resulted in the improvement of cell viability in primary porcine cardiomyocytes against simulated ischemic reperfusion induction. The findings from cardiac surgery demonstrated that mean arterial pressure and heart rate are constantly stable in cardioplegic solution combined with the GBR group, while the trend of potassium and lactase concentration was decreased in the animals receiving GBR group. Consistently, all parameters from arterial blood gas showed better outcomes in animals receiving GBR; however, there were no statistically significant differences between groups, except hepatic enzymes. Conclusion: Therefore, GBR might exert cardio-protective effects against ischemic reperfusion injury in the porcine cardiac surgery model due to anti-inflammatory response. These protective actions of GBR may explain the benefits gained from applying GBR products as a possible therapeutic supplement on cardiac diseases.

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Section: Resultsmentioning

confidence: 99%