Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia

Soška, Vladimír; Dobšák, Petr; Dušek, Ladislav; Shirai, Kohji; Jarkovský, Jiří; Novàkovâ, Marie; Brhel, Petr; Šťastná, Jana; Fajkusová, Lenka; Freiberger, Tomáš; Yambe, Tomoyuki

doi:10.5551/jat.9639

Cited by 33 publications

(30 citation statements)

References 48 publications

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“…Soska et al 42) showed that CAVI was not high in heterozygous familiar hypercholesterolemic patients. On the other hand, some reports showed that CAVI is related to low-density lipoprotein (LDL) cholesterol level and also to the cholesterol / high-density lipoprotein (HDL) cholesterol ratio 43) .…”

Section: (C) Dyslipidemiamentioning

confidence: 99%

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Saiki

Sato

Watanabe

et al. 2016

J Atheroscler Thromb

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Measurement of arterial stiffness in routine medical practice is important to assess the progression of arteriosclerosis. So far, many parameters have been proposed to quantitatively represent arterial stiffness. Among these, pulse wave velocity (PWV) has been most frequently applied to clinical medicine because those could be measured simply and non-invasively. PWV had established the usefulness of measuring arterial wall stiffness. However, PWV essentially depends on blood pressure at the time of measurement. Therefore, PWV is not appropriate as a parameter for the evaluation of arterial stiffness, particularly for the studies involving blood pressure changes.On the other hand, stiffness parameter is an index reflecting arterial stiffness without the influence of blood pressure. Recently, this parameter has been applied to develop a new arterial stiffness index called cardio-ankle vascular index (CAVI). Therefore, CAVI does not depend on blood pressure changes during the measurements; CAVI could represent the stiffness of the arterial tree from the origin of the aorta to the ankle.Many clinical studies obtained from CAVI are being accumulated. CAVI showed high value in arteriosclerotic diseases, such as coronary artery diseases, cerebral infarction, and chronic kidney diseases, and also in majority of people with various coronary risk factors. The improvement of those risk factors decreased CAVI. Furthermore, the role of CAVI as a predictor of cardio-vascular events was reported recently.We review the clinical studies on CAVI and discuss the clinical usefulness of CAVI as a candidate surrogate end-point marker for cardiovascular disease.

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Section: (C) Dyslipidemiamentioning

confidence: 99%

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Saiki

Sato

Watanabe

et al. 2016

J Atheroscler Thromb

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show abstract

“…This was consistent with the findings from the previous by Soska et al They compared CAVI in FH patients and in healthy controls. 33 There was no signi ficant difference in HDL-cholesterol levels between FH patients and the controls. 33 In our study, there was also no significant difference in HDL-cholesterol levels between patients with and without CAS, although LDL-cholesterol level was higher in patients with CAS.…”

Section: Multiple Regression Analysis Of Various Parameters For Casmentioning

confidence: 97%

“…33 There was no signi ficant difference in HDL-cholesterol levels between FH patients and the controls. 33 In our study, there was also no significant difference in HDL-cholesterol levels between patients with and without CAS, although LDL-cholesterol level was higher in patients with CAS. On the other hand, another study showed that a significant increase in CAVI was observed in patients with combined hyperlipidemia who had a low (,40 mg/dL) HDL-cholesterol level but not in patients with hypercholesterolemia alone.…”

Section: Multiple Regression Analysis Of Various Parameters For Casmentioning

confidence: 97%

“…Nevertheless, the predictive ability of CAVI for coronary artery disease in FH patients has not yet been fully investigated. Although it is reported that CAVI is not elevated in FH patients, 33 hypercholesterolemia is associated with CAVI. 34 Therefore, in the present study, we aimed to determine whether CAVI could be a predictor of coronary atherosclerosis in asymptomatic FH patients.…”

Section: Introductionmentioning

confidence: 95%

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Frequency of coronary artery stenosis in patients with asymptomatic familial hypercholesterolemia and its association with carotid intimal thickness and cardio-ankle vascular index

Suzuki¹,

Takahashi²,

Iizuka³

et al. 2016

RRCC

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“…The highest CAVI was found in the group of patients with increased LDLcholesterol as well as hs-CRP. Moreover, CAVI in patients with dyslipidaemia may be influenced also by treatment with hypolipidaemics 36,37) . It has been reported that statins decrease CAVI and improve arterial stiffness in patients with coronary artery disease and hyperlipidaemia 38,39) .…”

Section: Disclosurementioning

confidence: 99%

Cardio-Ankle Vascular Index in Subjects with Dyslipidaemia and Other Cardiovascular Risk Factors

Soška

Frantisová

Dobšák

et al. 2013

JAT

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Aim:The cardio-ankle vascular index (CAVI) is a novel non-invasive marker of arterial stiffness and atherosclerosis. The aim of this work was to examine whether the CAVI value in patients with dyslipidaemia (DLP) is increased by the presence of other cardiovascular risk factors: hypertension, diabetes mellitus, and smoking. Methods: A total of 392 subjects with DLP (166 male, 226 female), with a median age of 58.5 and 5-95 percentile range 32.2-73.9 years were examined. CAVI was measured using the VaSera 1500 system. Results: CAVI correlated significantly with age (p＜0.001) and both systolic (p＜0.001) and diastolic (p=0.002) blood pressure; higher values were found in men (p= 0.034) than in women in the 56-65 age group. There was no significant difference in CAVI between smokers and non-smokers (p = 0.217) and between subjects with and without diabetes mellitus (p=0.424). CAVI was significantly higher in subjects with hypertension than in the normotensive group (p＜0.001) and in statin-treated subjects than in those without statins (p＜0.001); however, CAVI values adjusted for age and sex did not differ significantly between these groups. Adjusted CAVI values were higher only in smokers than in non-smokers (former smokers) (p＜0.001). Conclusion:The study proves conclusively that the CAVI value in DLP patients is not significantly affected by hypertension and diabetes mellitus, but it is increased by smoking.

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Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia

Cited by 33 publications

References 48 publications

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Frequency of coronary artery stenosis in patients with asymptomatic familial hypercholesterolemia and its association with carotid intimal thickness and cardio-ankle vascular index

Cardio-Ankle Vascular Index in Subjects with Dyslipidaemia and Other Cardiovascular Risk Factors

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