Cardio-Ankle Vascular Index in Subjects with Dyslipidaemia and Other Cardiovascular Risk Factors

Soška, Vladimír; Frantisová, Michaela; Dobšák, Petr; Dušek, Ladislav; Jarkovský, Jiří; Novàkovâ, Marie; Shirai, Kohji; Fajkusová, Lenka; Freiberger, Tomáš

doi:10.5551/jat.15420

Cited by 18 publications

(12 citation statements)

References 36 publications

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“…Takaki et al reported that the CAVI has a poor relationship with both the total and LDL cholesterol levels, and there is no observed correlation between the CAVI values and triglyceride and HDL cholesterol levels (9). Satoh et al reported that an increased CAVI is significantly correlated with the triglycerides and HDL cholesterol levels in men, but not women (46). This observation may reflect a difference in the pathophysiological mechanisms underlying dyslipidemia between men and women.…”

Section: Discussionmentioning

confidence: 87%

Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects

Tsuboi

Ito²,

Fujikawa³

et al. 2015

Intern. Med.

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Objective Although a relationship between post-challenge hyperglycemia and arterial stiffness has been reported, the relationship between the postprandial glucose levels and cardio-ankle vascular index (CAVI) in non-diabetic subjects is not clear. This study thus evaluated the association between the postprandial glucose levels after a composite meal and the degree of arterial stiffness measured according to CAVI in non-diabetic subjects. Methods The subjects included 1,291 individuals (655 men and 636 women; mean age, 48.6 years; range, 23-85 years) who underwent medical examinations, including blood tests and CAVI assessments, between October 2005 and April 2012. The 1-hour postprandial glucose levels were determined after a 600-kcal traditional Japanese meal. ResultsThe CAVI values were significantly higher in the subjects with higher 1-hour postprandial glucose levels (! 140 mg/dL in men; ! 158 mg/dL in women). A simple regression analysis indicated that the CAVI values were significantly correlated with the 1-hour postprandial glucose levels in men (r=0.286, p<0.0001) and women (r=0.228, p<0.0001). After adjusting for age, BMI, systolic blood pressure, triglycerides, highdensity lipoprotein cholesterol, low-density lipoprotein cholesterol, 1-hour postprandial glucose, homeostatis model assessment of insulin resistance, estimated glemerular filtration rate, and high sensitive C-reactive protein, stepwise multiple regression analysis demonstrated that the 1-hour postprandial glucose level was an independent predictor associated with the CAVI in men (p=0.003) and older women 50 years of age or older (p=0.003). Conclusion This study demonstrated that the 1-hour postprandial glucose levels are associated with increased CAVI values in non-diabetic men and older women 50 years of age or older.

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Section: Discussionmentioning

confidence: 87%

Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects

Tsuboi

Ito²,

Fujikawa³

et al. 2015

Intern. Med.

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“…In our study population, however, no blood lipid parameters were associated with the ageadjusted CAVI ( Table 2). In concordance with these results, several studies have failed to detect a significant association between the CAVI and blood lipid levels [36][37][38] . Higashiyama et al 36) reported that the CAVI is more strongly correlated with the high-sensitivity C-reactive protein (hs-CRP) level than with the LDL cholesterol level.…”

Section: Resultsmentioning

confidence: 52%

Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

Tanisawa

Ito

Sun

et al. 2015

JAT

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Aim: This study aimed to examine whether cardiorespiratory fitness (CRF) is associated with arterial stiffening, evaluated using the cardio-ankle vascular index (CAVI), independent of visceral fat (VF) in middle-aged and elderly Japanese men. We also examined whether the relationship between CRF and the CAVI is modified by age and/or hypertension. Methods: The CAVI was determined in 157 Japanese men (age range, 30-79 years), including 96 hypertensive subjects (61.1%). CRF was assessed by measuring the peak oxygen uptake (V 4 O2peak). The subjects were divided into low-and high-CRF groups, and the VF area was assessed using magnetic resonance imaging.

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“…Specifically, studies that compared CAVI with invasive coronary artery angiography or cardiac computed tomography angiography (CCTA) indicated a significant relationship between CAVI and coronary artery disease (CAD) . Although CAVI has been extensively studied and recognized as a tool to predict cardiovascular risk, most studies have been conducted in Asian countries . This is a pilot study to investigate whether CAVI can predict severity, extent, and burden of CAD by comparing results with CCTA in a US population.…”

Section: Introductionmentioning

confidence: 99%

The relationship between cardio‐ankle vascular index and subclinical atherosclerosis evaluated by cardiac computed tomographic angiography

Matsumoto

Nakanishi

Luo

et al. 2017

Clinical Cardiology

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Background The cardio‐ankle vascular index (CAVI) is a new noninvasive index to evaluate arterial stiffness. We investigated whether CAVI can predict severity, extent, and burden of coronary artery disease by comparing results with cardiac computed tomographic angiography (CCTA). Hypothesis CAVI may predict the presence of subclinical atherosclerosis. Methods We prospectively enrolled 95 patients (66% male; mean age, 50 ± 16 years) who underwent both CCTA and CAVI consecutively. We evaluated if CAVI correlated with (1) severe stenosis (≥50%); (2) plaque extent, determined by a segment‐involvement score (SIS), defined by the total number of coronary artery segments containing any plaque; and (3) plaque burden, determined by a segment‐stenosis score (SSS), defined by the extent of obstruction of coronary luminal diameter in individual coronary artery segments. Results Bivariate analysis showed a statistically significant relationship not only between CAVI and SIS, but also between CAVI and SSS (r2 = 0.4, P < 0.0001 for SIS; r2 = 0.36, P < 0.0001 for SSS). Multivariable logistic analysis demonstrated that CAVI is significantly associated with SSS >5 (odds ratio [OR]: 2.3, 95% confidence interval [CI]: 1.1‐7.8, P = 0.03) and SIS >5 (OR: 2.3, 95% CI: 1.1‐5.8, P = 0.02), but not severe stenosis (OR: 1.7, 95% CI: 0.9‐4.3, P = 0.13), after adjusting for age, sex, chest pain, hypertension, dyslipidemia, family history, diabetes, and current smoking. Conclusions We demonstrated that CAVI had a significant relationship with subclinical coronary atherosclerosis evaluated by CCTA, especially in relation to plaque burden and plaque extent, but not severe stenosis. Thus, CAVI may reflect coronary atherosclerosis burden more than severity.

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Cardio-Ankle Vascular Index in Subjects with Dyslipidaemia and Other Cardiovascular Risk Factors

Cited by 18 publications

References 36 publications

Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects

Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects

Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

The relationship between cardio‐ankle vascular index and subclinical atherosclerosis evaluated by cardiac computed tomographic angiography

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