Cardio- and reno-protective effect of remote ischemic preconditioning in patients undergoing percutaneous coronary intervention. A prospective, non-randomized controlled trial

Cardioprotective Effect of Losartan Alone or in Combination with Remote Ischemic Preconditioning on the Biochemical Changes Induced by Ischemic/Reperfusion Injury in a Mutual Prospective Study with a Clinical and Experimental Animal Arm

“…32 Also the use of RIPC<2 h before PCI, reduces the incidence of PCI-related MI and improves ischemic symptoms in patients undergoing elective PCI in our previous report on 200 patients undergoing PCI. 33 In the current study, the additive cardioprotective biochemical effects of RIPC combined with Losartanin the animal model of I/R and Losartanin the clinical part encourages a suggestion to use the RIPC plus pharmacological preconditioning (Losartan in this study) for cardiac patients before doing PCI at least to guard against periprocedure cardiac injury.…”