Cardioprotective Effect of Losartan Alone or in Combination with Remote Ischemic Preconditioning on the Biochemical Changes Induced by Ischemic/Reperfusion Injury in a Mutual Prospective Study with a Clinical and Experimental Animal Arm

Desoky, Ehab S El; Hassan, Aslinda; Salem, Safaa Y.; Fadil, Sabah A.; Taha, Amira

doi:10.17140/hroj-4-142

Cited by 3 publications

(2 citation statements)

References 25 publications

(31 reference statements)

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“…In contrast to losartan, Ang II treatment in IPC mice increased morphological damage, oxidative stress, and inflammatory responses, along with functional impairment ( 62 ). The cardioprotective benefits of IPC against I/R injury were improved when losartan was co-administered with IPC ( 63 ).…”

Section: Discussionmentioning

confidence: 99%

Renal vascular responses to angiotensin II infusion in two kidneys-one clip hypertensive rats under partial ischemia/reperfusion with and without ischemia preconditioning: the roles of AT1R blockade and co-blockades of AT1R and MasR

Karimi¹,

Nematbakhsh

2023

Research in Pharmaceutical Sciences

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Background and purpose: The renin-angiotensin system activation, partial ischemia/reperfusion (IR) injury, and hypertension contribute to the development of acute kidney injury. The study aims to look at the vascular responses of angiotensin II (Ang II) during Ang II type 1 receptor (AT1R) blockade (losartan) or co-blockades of AT1R and Mas receptor (A779) in two kidneys one clip (2K1C) hypertensive rats which subjected to partial IR injury with and without ischemia preconditioning (IPC). Experimental approach: Thirty-three 2K1C male Wistar rats with systolic blood pressure ≥ 150 mmHg were divided into three groups of sham, IR, and IPC + IR divided into two sub-groups receiving losartan or losartan + A779. The IR group had 45 min partial kidney ischemia, while the IPC + IR group had two 5 min cycles of partial ischemia followed by 10 min of reperfusion and then 45 min of partial kidney ischemia followed by reperfusion. The sham group was subjected to similar surgical procedures except for IR or IPC. Findings/Results: Ang II increased mean arterial pressure in all the groups, but there were no significant differences between the sub-groups. A significant difference was observed in the renal blood flow response to Ang II between two sub-groups of sham and IR groups treated with AT1R blockade alone or co-blockades of AT1R + A779. Conclusion and implications: These findings demonstrated the significance of AT1R and Mas receptor following partial renal IR in the renal blood flow responses to Ang II in 2K1C hypertensive rats.

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Section: Discussionmentioning

confidence: 99%

Renal vascular responses to angiotensin II infusion in two kidneys-one clip hypertensive rats under partial ischemia/reperfusion with and without ischemia preconditioning: the roles of AT1R blockade and co-blockades of AT1R and MasR

Karimi¹,

Nematbakhsh

2023

Research in Pharmaceutical Sciences

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“…Losartan is a nonpeptide angiotensin receptor II (Ang II) antagonist that lowers blood pressure and is well tolerated as it also inhibits angiotensin II binding to the type 1 receptor. Losartan has been shown to reduce hypertension, prevent cardiovascular morbidity and mortality, and protect heart function by preventing the deleterious effects on Ang II on ischemic/reperfused myocardium (EL Desoky et al 2017). Similarly, the GWF had remarkable cardioprotective efficacy not shared by the other fractions despite comparable antihypertensive activity, suggesting the presence of additional cardioprotective agents.…”

Section: Discussionmentioning

confidence: 99%

Repercussions of pathway inhibition response of Panaxginseng fractions ameliorate cardiac dysfunction in hypertensive model rats

Ali

Shalaby

Ragab

et al. 2022

ijhs

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This study examined the preventive and therapeutic benefits of various Panax ginseng fractions against NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension in rats. Rats injected with L-NAME plus vehicle exhibited persistently elevated SBP, serum concentrations of the cardiac injury biomarkers creatine kinase (CK), CK-MB, and troponin, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), and interleukin (IL)-6, but lower high-density lipoprotein (HDL) compared to the vehicle control group. Furthermore, L-NAME disrupted the normal histological structure and function of rat cardiac tissue. All ginseng fractions and losartan restored SBP to a normal level, reversed the changes in CK, CK-MB, troponin, total cholesterol, TG, HDL, and LDH, and preserved normal myocardial histology, with the WGF demonstrating the greatest cardioprotective and antihypertensive effects. Compounds within multiple ginseng fractions, but especially the aqueous fraction, possess potent and effective antihypertensive, antilipidemic, anti-inflammatory, and cardioprotective properties.

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Vascular Effects of Avocado Seed Glycosides during Diabetes-induced Endothelial Damage

Amadi

Agomuo

Adumekwe

2020

CHDDT

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Background and objectives:: The relationship between vascular damage and diabetes mellitus was exploited using avocado seed extracts. The purpose of the study was to understand the therapeutic relevance of glycosides compared to standard vascular and anti-diabetic drugs. Constituent avocado seed glycosides (ASG) were analysed and administered to rats with diabetes-induced vascular damage (DIVD). Method: The rats were first administered with streptozotocin and screened after seven days for alterations in blood glucose, insulin, vascular cell adhersion molecule (VCAM-1), Von Willebrond factor (VWF), Renin-Angiotensin-Aldosterone System(RAS), eNOx, and endothelin-1 (ET-1). Only rats that satisfied these criteria were recruited and treated with either glibenclamide, met.su + losart, or 200 mg/kg body weight ASG for 28 days. Result: There was an abundance of digitoxin (13.41 mg/100g), digoxin (17.98 mg/100g), avicularin (165.85 mg/100g), and hyperoside (282.51 mg/100g). ASG or met.su + losartexhibited slight modulatory properties on glucose homeostasis. Rats withDIVD showed elevated renin, angiotensin, VCAM-1 and Lp-PLA2 levels but slightly decreased with glibenclamide treatment and normalized with ASG or met.su + losart administration. All treatments normalized Hcy levels. DIVD caused the overproduction of CnT, LDH, CrtK, LDL-c, TG, and TC and suppressed HDL-c but were completely normalized by the ASG. Water intake remained altered in treated rats. Conclusion: The ASG had no relevant effect on glucose homeostasis during DIVD but showed significant vasoprotective properties.

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Cardioprotective Effect of Losartan Alone or in Combination with Remote Ischemic Preconditioning on the Biochemical Changes Induced by Ischemic/Reperfusion Injury in a Mutual Prospective Study with a Clinical and Experimental Animal Arm

Cited by 3 publications

References 25 publications

Renal vascular responses to angiotensin II infusion in two kidneys-one clip hypertensive rats under partial ischemia/reperfusion with and without ischemia preconditioning: the roles of AT1R blockade and co-blockades of AT1R and MasR

Renal vascular responses to angiotensin II infusion in two kidneys-one clip hypertensive rats under partial ischemia/reperfusion with and without ischemia preconditioning: the roles of AT1R blockade and co-blockades of AT1R and MasR

Repercussions of pathway inhibition response of Panaxginseng fractions ameliorate cardiac dysfunction in hypertensive model rats

Vascular Effects of Avocado Seed Glycosides during Diabetes-induced Endothelial Damage

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