Cardio- and hepato-protective potential of methanolic extract of Syzygium cumini (L.) Skeels seeds: A diabetic rat model study

Nahid, Sumaiya; Mazumder, Kishor; Rahman, Zillur; Islam, Saiful; Rashid, Mahbub; Kerr, Philip G.

doi:10.1016/j.apjtb.2016.11.025

Cited by 29 publications

(23 citation statements)

References 24 publications

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“…In vivo studies indicated the beneficial effects of some polyphenols in DCM such as methanolic extract of S. cumini seeds treated group showed normal morphological cardiac features compared to the diabetic control. This may be due to the presence of quercetin, ellagic acid, rutin, and gallic acid in the extract which contributes to reducing aspartate aminotransferase (AST), creatine kinase-MB (CK-MB), and lactate dehydrogenase (LDH) level up to the normal ( 46 , 47 ). The combined effect of A. sativum and voluntary exercise has worked as a powerful defense system, which decreases HbA1c and malondialdehyde (MDA) production in cardiomyocytes of diabetic models ( 48 ).…”

Section: Natural Polyphenols: Therapeutics Of Dcmmentioning

confidence: 99%

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

2020

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Diabetic cardiomyopathy (DCM) is an outcome of disturbances in metabolic activities through oxidative stress, local inflammation, and fibrosis, as well as a prime cause of fatality worldwide. Cardiovascular disorders in diabetic individuals have become a challenge in diagnosis and formulation of treatment prototype. It is necessary to have a better understanding of cellular pathophysiology that reveal the therapeutic targets and prevent the progression of cardiovascular diseases due to hyperglycemia. Critical changes in levels of collagen and integrin have been observed in the extracellular matrix of heart, which was responsible for cardiac remodeling in diabetic patients. This review explored the understanding of the mechanisms of how the phytochemicals provide cardioprotection under diabetes along with the caveats and provide future perspectives on these agents as prototypes for the development of drugs for managing DCM. Thus, here we summarized the effect of various plant extracts and natural polyphenols tested in preclinical and cell culture models of diabetic cardiomyopathy. Further, the potential use of selected polyphenols that improved the therapeutic efficacy against diabetic cardiomyopathy is also illustrated.

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Section: Natural Polyphenols: Therapeutics Of Dcmmentioning

confidence: 99%

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

2020

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“…The extract of T. arjuna restored the cellular arrangement in the central veins and decreased the necrosis (Ragavan and Krishnakumari, 2006). Ethanolic extract of T. arjuna showed the standard features in the liver of hyper-lipidemic rats (Shankreppa et al, 2015) and the methanolic extract of S. cumini seedstreated groups showed very favourable results when compared to standard group (Nahid et al, 2017).…”

Section: Discussionmentioning

confidence: 95%

Assessment of anti-diabetic activity of alcoholic and hydro-alcoholic extract of Terminalia arjuna & Syzygium cumini in streptozotocin-induced diabetes in Wistar rats

Takru¹,

K²,

Kapil³

et al. 2020

ijrps

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We aimed to evaluate the effect of anti-diabetic activity of Terminalia arjuna, and Syzygium cumini extracts in Streptozotocin (STZ) induced diabetes in Wistar rats. STZ (55mg/kg) followed by nicotinamide (100mg/kg) was given to rats by intraperitoneal route to induce diabetes. Oral administration of alcoholic and hydro-alcoholic extracts of T. arjuna (TAAE) (250mg/kg and 500mg/kg), S. cumini (SCAE) (200mg/kg and 400mg/kg) and their composite extract were given to rats along with standard anti-diabetic drug Glibenclamide (5mg/kg). We evaluated body weight, glucose level, lipid profile and biochemical parameters in STZ induced diabetic rats. Also, histopathological studied were done in liver, kidney and pancreatic tissues of rats. Our finding revealed that TAAE and TAHE at 250mg/kg b.w. and 500mg/kg b.w., SCAE and SCHE at 400mg/kg b.w. and combination of TAAE (250mg/kg b.w.)+SCAE (400mg/kg b.w.) had a positive effect in lowering the blood glucose level and body weight on 28th day as compared to the initial observation on 0th day and also restored all the biochemical parameters such as LDL, VLDL, triglycerides and total Cholesterol and HDL towards the normal levels as well as histopathological improvement in Kidney, Liver and Pancreas. Data analysis showed that composite extract of TAAE (250mg/kg) and SCAE (400mg/kg ) improved diabetic consequences more effectively than composite extract of TAHE (500mg/kg) and SCHE (400mg/kg). TAAE and SCHE, in combination, demonstrate as a potential therapeutic agent against diabetes.

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“…23 The methanolic extract study using 200 mg/kg for 14 days showed comparable blood glucose lowering effect as that of gliclazide 25 mgkg dose in comparison with diabetic control group. 24…”

Section: Seed Extractmentioning

confidence: 99%

Syzygium cumini (jamun) therapeutic potential: a comprehensive review on phytochemical constituents and emphasis on its pharmacological actions related to diabetic intervention

Asanaliyar¹,

Nadig²

2020

Int J Basic Clin Pharmacol

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Syzygium cumini or Eugenia Jambolana Lam is a traditional medicinal plant very native to the Indian and Asian sub-continent. It is commonly known as black plum or jamun. Various plants parts of the tree are known for ethno-medicinal uses, and in particular, the fruits of Jamun tree are well known for medicinal uses and preparation of health drinks. Studies have shown that the berries contain carbohydrates, minerals and the pharmacologically active phytochemicals. The active phytochemical includes flavonoids, terpenes, and anthocyanins. Ayurvedic and Indian Folk Medicine have already mentioned the use of jamun for diabetic treatment even before the advent of insulin. The bark, fruit pulp, seeds and the leaves are evaluated in the crude form as well as extracts in various diabetic models. Further, bioactive phytochemicals are extracted using in vitro assays, some of them such as vitalboside-A, mycominose are also characterized with spectroscopic analysis. This review article is intended to compile Syzygium cumini’s therapeutic potential with special emphasis on the phytochemical constituents and its pharmacological activities related to diabetic intervention through recent studies conducted in last one decade. It also addresses the clinical and toxicological studies.

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Cardio- and hepato-protective potential of methanolic extract of Syzygium cumini (L.) Skeels seeds: A diabetic rat model study

Cited by 29 publications

References 24 publications

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

Assessment of anti-diabetic activity of alcoholic and hydro-alcoholic extract of Terminalia arjuna & Syzygium cumini in streptozotocin-induced diabetes in Wistar rats

Syzygium cumini (jamun) therapeutic potential: a comprehensive review on phytochemical constituents and emphasis on its pharmacological actions related to diabetic intervention

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