Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates

Fortunato, Giuliana; Giarrusso, Patrizia Carandente; Martinelli, Pasquale; Sglavo, G.; Vassallo, M.; Tomeo, Luigi; Rea, Michelangelo; Paladini, D.

doi:10.1515/cclm.2006.144

Cited by 30 publications

(39 citation statements)

References 16 publications

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“…Additionally, cross reaction with fetal muscular troponin T cannot be excluded. The theory seems to be confirmed by studies conducted by Fortunato et al [9] in which cTnT concentrations in 22 healthy fetuses at 22-25 weeks of gestational age were comparable to concentrations found in preterm newborns born at 30 weeks of gestational age [9]. However, the studies performed by Clark et al [16] revealed that postnatal cTnT concentrations were usually higher than evaluated in cord blood.…”

Section: Discussionmentioning

confidence: 73%

The Evaluation of Cardiac Troponin T in Newborns

Tarkowska

Furmaga-Jabłońska

2017

Biomed Hub

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Introduction: In this paper, we evaluated the physiologic ranges of cardiac troponin T (cTnT) serum concentrations in healthy newborns. This is significant because these ranges have not been determined yet, especially for newborns older than 7 days. Cardiac troponins are widely used as diagnostic markers in adults; however, they cannot be routinely used in infants due to lack of data concerning normal values in this age group. Aim: To determine the physiologic ranges of cTnT concentrations in newborns and to evaluate the influence of factors such as age, sex, and blood saturation. Methods: The study involved 59 newborns up to 46 weeks of postmenstrual age (full-term and preterm). The exclusion criteria were severe perinatal asphyxia and presence of severe diseases. Troponin T concentrations were evaluated by the Roche CARDIAC T Quantitative Test. The obtained results were statistically analyzed by the use of the Statistica 9.0 computer program. Results: The study revealed that cTnT levels in newborns correlate with postmenstrual age, but not with chronologic or fetal age. Sex, delivery mode, and blood oxygenation did not influence cTnT concentrations in the studied patients. Conclusions: (1) Cardiac troponin T concentration depends on postmenstrual age in newborns. (2) Cardiac troponin T concentration in newborns does not depend on sex, mode of delivery, or blood saturation.

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Section: Discussionmentioning

confidence: 73%

The Evaluation of Cardiac Troponin T in Newborns

Tarkowska

Furmaga-Jabłońska

2017

Biomed Hub

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“…However, Fortunato et al reported that NT-proBNP was significantly higher in infants delivered by elective cesarean section than in infants delivered after spontaneous birth. In fact, NT-proBNP levels were higher after elective cesarean section than after a cesarean section carried out during active labor, suggesting that the decrease in NT-proBNP levels is probably attributable to labor rather than to the mode of delivery (19).…”

Section: Natriuretic Peptidesmentioning

confidence: 93%

Use of cardiac biomarkers in neonatology

et al. 2012

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“…BNP plays a major role in the organogenesis of the fetal heart and during the transition of newborn infants (NBIs) to extrauterine life. 3,4 In the first week of life, BNP levels are normally high, up to 12 times higher than maternal levels, since it does not cross the placental barrier. Such high value observed among healthy NBIs in the first days of life tends to return to normal with physiological loss in weight reaching a level similar to that observed in adults.…”

Section: Introductionmentioning

confidence: 99%

B-type natriuretic peptide: Usefulness in the management of critically-ill neonates

et al. 2017

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B-type natriuretic peptide (BNP) is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life. In the first week of life, BNP levels are high and return to normal with the physiological loss in weight. High BNP levels are associated with different conditions. Objective. To establish the relationship between BNP levels and criticality and the short-term clinical course among patients hospitalized in the neonatal intensive care unit. Method. Observational and analytical study conducted in a prospective cohort. Criticality was defined as a requirement for assisted mechanical ventilation with a fraction of inspired oxygen of more than 50% and/or inotropes. Two blood samples were collected 72 hours apart. Results. Seventy-three patients were included in the study. Depending on their clinical course on day 7, they were divided into 2 groups: patients with a good clinical course or a persistent, severe clinical course. The median baseline BNP level was similar in both groups (p: 0.15). The median BNP level at 72 hours was higher among patients with a persistent, severe clinical course (p: 0.005). The difference between both BNP values was calculated (∆BNP: BNP level at 72 hours -BNP level at 0 hours). The ∆BNP was positive among patients with a persistent, severe clinical course (X= 1260 pg/mL; range: 426-2094) and negative in the group with a good clinical course (X= -967 pg/mL; range: -1656/-278) (p: 0.0002); sensitivity: 87%; specificity: 86%; positive predictive value: 74%; and negative predictive value: 93%. Conclusion. In this group of patients, the delta-BNP value reflected the short-term clinical course.

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Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates

Cited by 30 publications

References 16 publications

The Evaluation of Cardiac Troponin T in Newborns

The Evaluation of Cardiac Troponin T in Newborns

Use of cardiac biomarkers in neonatology

B-type natriuretic peptide: Usefulness in the management of critically-ill neonates

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