Cardiac troponin-I concentrations in dogs with bradyarrhythmias before and after artificial pacing

Trafny, Dennis J.; Oyama, Mark A.; Wormser, Chloe; Reynolds, Caryn; Singletary, Gretchen E.; Peddle, Gordon D.

doi:10.1016/j.jvc.2010.07.002

Cited by 19 publications

(17 citation statements)

References 54 publications

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“…A few studies showed that dogs with AVB frequently have cTnI serum concentrations above the reference range. This is likely secondary to decreased cardiac output, structural remodeling secondary to volume overload, presence of congestive heart failure, or underlying cardiomyopathy or myocarditis . In 1 study, myocarditis was suspected in dogs with AVB that had very high serum cTnI concentrations and concurrent positive Bartonella spp.…”

Section: Discussionmentioning

confidence: 98%

“…In 1 study, myocarditis was suspected in dogs with AVB that had very high serum cTnI concentrations and concurrent positive Bartonella spp. serology or in dogs that developed a dilated‐hypokinetic phenotype after PMI with persistently increased cTnI serum concentrations . Other possible explanations, besides chronic myocarditis, for these cases include cardiomyopathy with secondary AVB or pacing‐induced cardiomyopathy …”

Section: Discussionmentioning

confidence: 99%

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Long‐term Intrinsic Rhythm Evaluation in Dogs with Atrioventricular Block

Santilli¹,

Vázquez²,

Vezzosi

et al. 2015

Veterinary Internal Medicne

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BackgroundAtrioventricular block (AVB) is a conduction abnormality along the atrioventricular node that, depending on etiology, may lead to different outcomes.ObjectivesTo evaluate variations of intrinsic rhythm (IR) in dogs that underwent pacemaker implantation (PMI).AnimalsMedical records of 92 dogs affected by 3rd degree atrioventricular block (3AVB), advanced 2nd degree AVB (2AVB), paroxysmal 3AVB, 2:1 2AVB, or 3AVB with atrial fibrillation (AF) were retrospectively reviewed.MethodThe patient IR was documented with telemetry on the day of 1 – (95% CI, 1–2), 33 – (95% CI, 28–35), 105 – (95%CI, 98–156), and 275 days (95%CI, 221–380) after PMI. According to AVB grade at different examinations, AVB was defined as progressed, regressed, or unchanged.ResultsIn 48 dogs, 3AVB remained unchanged, whereas in 7 it regressed. Eight cases of 2AVB progressed, 3 regressed and 2 remained unchanged. Eight cases of paroxysmal 3AVB progressed and 3 remained unchanged. Four dogs affected by 2:1 2AVB progressed, 2 regressed, and 1 remained unchanged. All cases with 3AVB with AF remained unchanged. Regression occurred within 30 days after PMI, whereas progression was documented at any time. Variations in IR were associated with type of AVB (P < .03) and time of follow‐up (P < .0001).Conclusions and clinical importanceThe degree of AVB assessed at the time of PMI should not be considered definitive because more than one‐third of the cases in this study either progressed or regressed. Additional studies would be necessary to elucidate possible causes for transient AVB in dogs.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Long‐term Intrinsic Rhythm Evaluation in Dogs with Atrioventricular Block

Santilli¹,

Vázquez²,

Vezzosi

et al. 2015

Veterinary Internal Medicne

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“…From the diagnostic point of view, one study tried to determine if serum cTnI concentration in dogs could distinguish between cardiogenic syncope and collapse due to either generalized epileptic seizures (both with and without cardiac disease) or VVS, but due to the overlap in cTnI concentrations between groups, measurement in an individual patient is not optimally discriminatory to differentiate them [101]. In other studies, it has been proven that serum cTnI concentration is high on presentation and shows significant reduction after PM implantation [40,41,69] although lead type and severity of the arrhythmia did not shown any correlation [40].…”

Section: Clinical Presentation and Diagnosis Av Conduction Disturbancesmentioning

confidence: 99%

“…In one of these case reports, a very high serum concentration of cardiac troponin I (cTnI) was documented and the authors suggested that this biomarker might help detect dogs with AVB secondary to active myocarditis [22]. Another study proved that cTnI is high at the time of presentation in dogs with permanent AVB but showed a significant reduction over time after PM implantation [40,41]. Lead type and arrhythmia severity did not show significant correlation with cTnI [40].…”

Section: Introductionmentioning

confidence: 99%

Indications for permanent pacing in dogs and cats

Santilli

Giacomazzi²,

Vázquez³

et al. 2019

Journal of Veterinary Cardiology

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Pacemaker implantation is considered as a standard procedure for treatment of symptomatic bradycardia in both dogs and cats. Advanced second-degree and third-degree atrioventricular blocks, sick sinus syndrome, persistent atrial standstill, and vasovagal syncope are the most common rhythm disturbances that require pacing to either alleviate clinical signs or prolong survival. Most pacemakers are implanted transvenously, using endocardial leads, but rarely epicardial leads may be necessary. To decide whether a patient is a candidate for pacing, as well as which pacing modality should be used, the clinician must have a clear understanding of the etiology, the pathophysiology, and the natural history of the most common bradyarrhythmias, as well as what result can be achieved by pacing patients with different rhythm disturbances. The goal of this review was, therefore, to describe the indications for pacing by evaluating the available evidence in both human and veterinary medicine. We described the etiology of bradyarrhythmias, clinical signs and electrocardiographic abnormalities, and the choice of pacing modality, taking into account how different choices may have different physiological consequences to selected patients. It is expected that this review will assist veterinarians in recognizing arrhythmias that may require permanent pacing and the risk-benefit of each pacing modality and its impact on outcome. ª

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“…Se ha determinado qué patologías extracardiacas que pueden producir un aumento notable de la tni en perros, posiblemente debido a lesión cardiaca secundaria a hipoxia o toxicosis, incluyen la piómetra, la parvovirosis [22], el síndrome de dilatación y el vólvulo gástrico (dtg), el derrame pericárdico [23], los traumatismos y las septicemias. Las miocarditis asociadas a babesia o tripanosoma [4], así como los perros positivos a Bartonella spp [24], pueden tener un aumento de hasta 100 veces su valor; igualmente, se han detectado incrementos en los niveles de tni en perros sanos sometidos a anestesia general [25].…”

Section: Troponinas Cardiacasunclassified

Biomarcadores cardiacos como ayuda diagnóstica en las cardiopatías

Salgado

Arango

2014

Spei Domus

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En la clínica diaria de pequeños animales, es común encontrarse con patologías cardiacas, para cuyo diagnóstico se utilizan técnicas imagenológicas como la radiografía, el electrocardiograma y la ecocardiografía. Sin embargo, a pesar de la amplia investigación sobre estas técnicas, todavía es difícil establecer con claridad el pronóstico de estos pacientes y evaluar objetivamente la evolución de dichas patologías; incluso, existen pacientes con cardiopatías ocultas que pueden pasar inadvertidas al examen clínico y a las ayudas imagenológicas. Es por este motivo que en los últimos años se vienen estudiando nuevos métodos para diagnosticar cardiopatías de forma rápida y eficaz; es el caso de los biomarcadores cardiacos, como las troponinas y los péptidos natriuréticos, que en medicina humana y animal se usan cada vez más para ayudar a establecer el diagnóstico, el pronóstico y la evolución de problemas cardiacos, con alta especificidad y sensibilidad. El presente artículo pretende actualizar los conceptos sobre el manejo de biomarcadores cardiacos en el diagnóstico cardiológico de perros y gatos.

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Cardiac troponin-I concentrations in dogs with bradyarrhythmias before and after artificial pacing

Cited by 19 publications

References 54 publications

Long‐term Intrinsic Rhythm Evaluation in Dogs with Atrioventricular Block

Long‐term Intrinsic Rhythm Evaluation in Dogs with Atrioventricular Block

Indications for permanent pacing in dogs and cats

Biomarcadores cardiacos como ayuda diagnóstica en las cardiopatías

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