Cardiac troponin I concentrations as a marker of neurodevelopmental outcome at 18 months in newborns with perinatal asphyxia

Montaldo, Paolo; Rosso, Roberto; Chello, Giovanni; Giliberti, Paolo

doi:10.1038/jp.2014.1

Cited by 31 publications

(30 citation statements)

References 25 publications

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“…In the same study, they found a correlation between the cTnI concentration, the duration of inotropes and the clinical grade of HIE, as well as a correlation between the Apgar scores at 5 minutes and the level of cTnI. They suggested that early samples of cTnI could provide a useful predictor for myocardial dysfunction, which in turn could be correlated with the severity of the asphyxia .…”

Section: Discussionmentioning

confidence: 83%

Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels

et al. 2015

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Section: Discussionmentioning

confidence: 83%

Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels

et al. 2015

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“… 23 , 35 , 45 – 53 Measurement of troponins has replaced the creatine kinase-MB (CK-MB) isoform as the biochemical test for cardiac involvement in neonates with neonatal encephalopathy. 45 , 46 , 54 Troponin levels have prognostic significance with regards to mortality and outcome in perinatal hypoxic ischemia, and elevation of cardiac troponin T and I levels appears to correlate with neurodevelopment at 18 months. 46 , 55 Elevation of cord troponin is a good early predictor of severity of encephalopathy from a perinatal hypoxic insult and mortality in term infants.…”

Section: Common Diseases That Manifest With Neonatal Cardiomyopathymentioning

confidence: 99%

Application of Neonatologist Performed Echocardiography in the Assessment and Management of Neonatal Heart Failure unrelated to Congenital Heart Disease

et al. 2018

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Neonatal heart failure (HF) is a progressive disease caused by cardiovascular and non-cardiovascular abnormalities. The most common cause of neonatal HF is structural congenital heart disease, while neonatal cardiomyopathy represents the most common cause of HF in infants with a structurally normal heart. Neonatal cardiomyopathy is a group of diseases manifesting with various morphological and functional phenotypes that affect the heart muscle and alter cardiac performance at, or soon after birth. The clinical presentation of neonates with cardiomyopathy is varied, as are the possible causes of the condition and the severity of disease presentation. Echocardiography is the selected method of choice for diagnostic evaluation, follow-up and analysis of treatment results for cardiomyopathies in neonates. Advances in neonatal echocardiography now permit a more comprehensive assessment of cardiac performance that could not be previously achieved with conventional imaging. In this review, we discuss the current and emerging echocardiographic techniques that aid in the correct diagnostic and pathophysiological assessment of some of the most common etiologies of HF that occur in neonates with a structurally normal heart and acquired cardiomyopathy and we provide recommendations for using these techniques to optimize the management of neonate with HF.

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“…Troponin levels have been shown to have a good prognostic value with regards to outcome in perinatal asphyxia, with high cardiac troponin I levels correlating well with neurodevelopment at 18 months 5. Given its use as biomarker, a possible false-positive result can have important implications from a clinical point of view and can mislead clinicians and lead to unnecessary treatments and interventions.…”

Section: Introductionmentioning

confidence: 99%

False-positive troponin I elevation in a newborn with neonatal encephalopathy

et al. 2019

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Serum biomarkers of myocardial damage are commonly used in babies after perinatal asphyxia. We present a case report of a persistently troponin I elevation without evidence of clinical or instrumental signs of myocardial ischaemia in a baby with perinatal asphyxia. When the blood was mixed with polyethylene glycol we found that the troponin I levels were falsely elevated due to interfering antibodies. This case shows that analytical errors may still occur despite modern immunoassay systems and underlines the need for further investigations to identify false-positive values in case of disagreement between clinical conditions and laboratory values.

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Cardiac troponin I concentrations as a marker of neurodevelopmental outcome at 18 months in newborns with perinatal asphyxia

Abstract: In asphyxiated neonates, cTnI concentrations within 12 h of birth correlate with medium-term outcome. Early cTnI concentration correlates with severity of HIE, myocardial dysfunction and with Bayley II scores at 18 months.

Cited by 31 publications

References 25 publications

Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels

Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels

Application of Neonatologist Performed Echocardiography in the Assessment and Management of Neonatal Heart Failure unrelated to Congenital Heart Disease

False-positive troponin I elevation in a newborn with neonatal encephalopathy

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