Cardiac transplantation for amyloid heart disease: The United Kingdom experience

Dubrey, Simon W; Burke, Margaret; Hawkins, Philip N.; Banner, Nicholas R.

doi:10.1016/j.healun.2003.08.027

Cited by 161 publications

(123 citation statements)

References 34 publications

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“…The larger series found was at the Harefield Hospital, England, in which, out of 10 operated cases, only one patient achieved late survival [9]. All other issues on the subject refer to isolate cases, however, there are reports that state the possibility of treatment for the amyloidosis disease as a real clinical alternative, which brings new expectations for these patients [1,[3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Also, favorable to this policy, there is the fact that the clinical therapy for this deposit disease has been attempted with reasonably initial success [2,6,9].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, reports in literature reveal clearly the possibility of recurrence of the disease, either in the heart or other organs [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Transplante cardíaco em amiloidose primária

Baumgratz

Vila

Guilhen

et al. 2009

Rev Bras Cir Cardiovasc

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Cardiac amyloidosis is a disease that highly compromises the survival expectancy after the beginning of the symptomatic phase, usually with sudden death as the final event. The aggression to other organs, although, can make heart transplantation a disputable form of treatment taking into consideration the shortage of organ donors. The aim is to report the evolution with a survival of seven years after heart transplantation and in fair condition of a patient with amyloidosis. One year after the heart transplantation, the patient was referred to renal transplantation also in consequence of the disease aggression. The patient evolution was favorable compared to three other patients also from our service, who died early after the diagnosis. Even considering the multi-systemic nature of amyloidosis, we can accept that in selected patients the heart transplantation is justified, taking into account the very ill prognosis of the disease.Descriptors: Amyloidosis. Heart transplantation. Cardiomyopathies/surgery. Resumo

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Section: Discussionmentioning

confidence: 99%

“…Also, favorable to this policy, there is the fact that the clinical therapy for this deposit disease has been attempted with reasonably initial success [2,6,9].…”

Section: Discussionmentioning

confidence: 99%

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Transplante cardíaco em amiloidose primária

Baumgratz

Vila

Guilhen

et al. 2009

Rev Bras Cir Cardiovasc

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“…Although in the United Kingdom study the patients were followed for two to six years with serial endomyocardial biopsies with no evidence of recurrent amyloid deposition during this time (Dubrey et al, 2004), five of the 11 patients reported by Lacy et al, demonstrated biopsy-proven recurrence in the cardiac allograft. Interestingly, none of these patients had symptoms, echocardiographic evidence, or biochemical evidence of cardiac amyloidosis.…”

Section: Recurrence Of Cardiac Amyloidosismentioning

confidence: 97%

“…Survival at four years was 39% and systemic progression was seen in the majority of patients. The Heart Transplant Centers in the European consortium reported a five-year survival of 38% in recipients with AL amyloidosis compared with 67% in recipients with HF due to non-amyloid cases (Dubrey et al, 2004). Amyloid deposition occurred in the graft in every case in which it was sought histologically, and progressive systemic amyloidosis contributed to mortality in 70% of patients (Dubrey et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Cardiac and Multi-Organ Transplantation in Patients with Amyloidosis

Raichlin¹,

Kushwaha²

2011

Amyloidosis - An Insight to Disease of Systems and Novel Therapies

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Amyloidosis and the Heart

Shah¹,

Inoue²,

Mehra³

2006

Arch Intern Med

211

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Infiltration of the heart from insoluble protein deposits in amyloidosis often results in restrictive cardiomyopathy that manifests late in its course with heart failure and conduction abnormalities. While the rare primary amyloidosis-related heart disease has been well characterized, senile amyloidosis occurring in the seventh decade of life most frequently affects the heart. Early diagnosis of cardiac amyloidosis may improve outcomes but requires heightened suspicion and a systematic clinical approach to evaluation. Demonstration of tissue infiltration of biopsy specimens using special stains, followed by immunohistochemical studies and genetic testing, is essential in defining the specific protein involved. The therapeutic strategy depends on the characterization of the type of amyloid protein and extent of disease and may include chemotherapy, stem cell transplantation, and liver transplantation. Heart transplantation is controversial and is generally performed only at isolated centers.

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Cardiac transplantation for amyloid heart disease: The United Kingdom experience

Cited by 161 publications

References 34 publications

Transplante cardíaco em amiloidose primária

Transplante cardíaco em amiloidose primária

Cardiac and Multi-Organ Transplantation in Patients with Amyloidosis

Amyloidosis and the Heart

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