Amyloidosis and the Heart

Shah, Keyur B.; Inoue, Yoshio; Mehra, Mandeep R.

doi:10.1001/archinte.166.17.1805

Cited by 211 publications

(96 citation statements)

References 103 publications

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“…Die Bezeichnung wurde 1834 von dem Hamburger Botaniker Matthias Schleiden zum ersten Mal bei der Beschreibung der wachsartigen Stärke in Pflanzen verwendet [1]. Später (1854) wählte Rudolf Virchow den Begriff als Erster zur Beschreibung eines atypischen Materials, das er in der Leber eines Verstorbenen gefunden hatte, da es, ebenso wie Stärke, bei der Zugabe von Jod eine Blaufärbung zeigte.…”

Section: Hereditäre Kardiale Amyloidosen Mit Mutationen Des Transthyrunclassified

“…Die systemisch verlaufende ATTR-Amyloidose ist die häufigste hereditäre Amyloidose [4] [1,4]. Derzeit sind über 90 Mutationen bekannt [5].…”

Section: Diskussionunclassified

“…Differenzialdiagnostisch abzugrenzen ist u. a. auch die senile systemische Amyloidose (SSA), welche bei nahezu 25% der über 80-jährigen Menschen (überwie-gend Männer) durch das Wildtyp-Transthyretin verursacht wird. Bei dieser Erkrankung können nahezu alle Organe betroffen sein [1,8].…”

Section: Diskussionunclassified

“…Später kommt es zu einer Hypertrophie der Muskulatur mit einer Zunahme der Festigkeit. Folglich sind die Erschlaffung sowie die Kontraktion der Muskulatur behindert, und es entsteht eine restriktive Kardiomyopathie [1,13,14].…”

Section: Diskussionunclassified

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Hereditäre kardiale Amyloidosen mit Mutationen des Transthyretin

Edler

Saeger

Orth

et al. 2012

Herz

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Hereditary amyloidoses present a clinically and genetically heterogeneous group of autosomal dominant diseases. The most frequent form is associated with mutations of the transthyretin gene. The type of mutation determines the process, the organs primarily involved as well as the time of onset of the disease. Life expectancy is generally limited by the degree of cardiomyopathy. The cases of two male patients who died suddenly and unexpectedly are presented. In both cases, autopsy revealed a biventricular cardiac hypertrophy. Cardiac amyloidosis was diagnosed by means of histologic and genetic analysis. Early diagnosis is essential for those affected, since liver transplantation still represents the only effective treatment. This illustrates the benefit of autopsy investigations for surviving relatives, who may themselves be affected by the disease.

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Section: Hereditäre Kardiale Amyloidosen Mit Mutationen Des Transthyrunclassified

“…Die systemisch verlaufende ATTR-Amyloidose ist die häufigste hereditäre Amyloidose [4] [1,4]. Derzeit sind über 90 Mutationen bekannt [5].…”

Section: Diskussionunclassified

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Hereditäre kardiale Amyloidosen mit Mutationen des Transthyretin

Edler

Saeger

Orth

et al. 2012

Herz

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“…Finally, amyloids are now associated with nonneurological disorders, including type 2 diabetes and some instances of heart failure. 26 Although amyloids have been identified as causes for many of these diseases, it is important to remember that there is still much debate whether, for all of these diseases, amyloids are the cause or simply an observable pathologic outcome. Nevertheless, with amyloid plaque deposition being recognized as a component of so many diseases with limited treatment options, a reasonable expectation now exists that, for at least some of these indications, targeting amyloid pathology will lead to therapeutically beneficial outcomes.…”

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Type 2 Diabetes and Alzheimer's Disease: From Common Pathologies to Potential New Therapeutics

Lévy¹

2007

J Diabetes Sci Technol

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Abbreviations: (AD) Alzheimer's disease, (PPARγ) peroxisome proliferator-activated receptor γ Keywords: Alzheimer's, amyloid, diabetes, insulin, islet, pancreatic, neuronal, plaques Throughout history, many plagues and illnesses have ravaged societies around the world. While through medicine, hygiene, and education we have largely been able to control or eliminate infectious and contagious ailments ranging from bubonic plague and leprosy to polio and small pox, we currently see an epidemic increase in diabetes. With over 20% of individuals over the age of 60 currently suffering from this disease and with an additional 1.5 million new cases diagnosed for patients over 20 years of age in 2005, diabetes is now among the greatest threats to public health today. Many factors are known to influence the risk of acquiring type 2 diabetes. Among these are genetic factors such as familial history and health factors including high blood pressure. 4 and grouped into respective classes. Although little can be done with respect to genetic risk factors and age for both diseases, appropriate lifest yle changes can impact health. Furthermore, the risk factors common to both diseases may allude to an underlying physiological link. Thus, as addressed in the following paragraphs, much interest is focused on the relationship between these diseases and the incidences of developing one once diagnosed with the other.Regarding therapeutic interventions for diabetes, current standards of care rely on control of blood glucose levels. However, in recent years, attention has focused on pancreatic function as it relates to diabetes. COMMENTARY AbstractType 2 diabetes constitutes a major health risk in the United States, with over 20% of individuals over the age of 60 currently suffering from this disease and an additional 1.5 million new cases diagnosed in patients over 20 years of age in 2005. Similarly, Alzheimer's disease represents a major risk to the aging population, with recent statistics estimating up to 16 million people diagnosed by 2050 in the United States alone. As type 2 diabetes and Alzheimer's disease are now recognized as members of the broader class of amyloid diseases and because the pathologies of disease progression between these indications is similar, common strategies focused on the design of next-generation therapeutics can be envisioned and are discussed herein.

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Indications for Permanent and Temporary Cardiac Pacing

Vijayaraman¹,

Peters²,

Ellenbogen³

2005

Cardiac Pacing and ICDs

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Fig. 1.1 A schematic diagram of the conduction system (SAN, sinus node; AVN, AV node; BH, bundle of His; LBB, left bundle branch; RBB, right bundle branch; AF, left anterior superior fascicle; PF, posterior inferior fascicle of the left bundle branch). The arterial supply is shown (RCA, right coronary artery; LAD, left anterior descending coronary artery; LCx, left circumfl ex coronary artery). For further description, see text.

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Amyloidosis and the Heart

Cited by 211 publications

References 103 publications

Hereditäre kardiale Amyloidosen mit Mutationen des Transthyretin

Hereditäre kardiale Amyloidosen mit Mutationen des Transthyretin

Type 2 Diabetes and Alzheimer's Disease: From Common Pathologies to Potential New Therapeutics

Indications for Permanent and Temporary Cardiac Pacing

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