Cardiac structure and function improvements in coronary artery disease combined with severe obstructive sleep apnea/hypopnea syndrome patients via noninvasive positive pressure ventilation therapy

Liu, Xinbing; Feng, Li; Cao, Guoliang; Huang, Hongman; Qi-tan, XU; Yu, Jianhua; Shu-fu, Zhang; Zhou, Mengmeng

doi:10.1097/mca.0000000000000129

Cited by 14 publications

(7 citation statements)

References 10 publications

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“…Results of Literature Quality Evaluation. A total of 351 literatures related to coronary heart disease and obstructive sleep apnea syndrome were retrieved, including 14 literatures [11][12][13][14][15][16][17][18][19][20][21][22][23][24] after independent screening and evaluation by two persons. Although 9 of the excluded literatures were case-control studies of coronary heart disease, coronary angiography was not performed in 6 of the excluded literatures, and the diagnostic criteria of obstructive sleep apnea syndrome were not clearly indicated in 3 of the excluded literatures.…”

Section: Resultsmentioning

confidence: 99%

Association of Obstructive Sleep Apnea Syndrome (OSA/OSAHS) with Coronary Atherosclerosis Risk: Systematic Review and Meta-Analysis

Chen

Zou

Wang

2022

Computational and Mathematical Methods in Medicine

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Objective. Obstructive sleep apnea syndrome (OSA) is the most common type of sleep disorders. This study aimed to systematically review the correlation between OSA and the risk of coronary atherosclerosis. Methods. Literature on case-control studies on the relationship between coronary heart disease (CHD) and sleep apnea syndrome was collected and collated, and the incidence of SAS in CHD and non-CHD patients was observed and compared. RevMan 5.2 analysis software and Stata12SE analysis software were used for heterogeneity test and combination analysis of the included studies. The results were expressed with odds ratio (OR), 95% confidence intervals (CI) were calculated, and publication bias and sensitivity tests were evaluated. Results. There was a statistical difference in OSA associated with the risk of coronary atherosclerosis between the experimental group and the control group [ OR = 1.38 , 95% CI (1.18, 1.62), P < 0.0001 , I 2 = 0 % , Z = 3.93 ]. OSA associated with vascular endothelial injury [ OR = 3.59 , 95% CI (3.00, 4.29), P < 0.00001 , I 2 = 90 % , Z = 14.09 ]. OSA is associated with vascular oxidation emergency [ OR = 2.19 , 95% CI (2.05, 2.33), P < 0.00001 , I 2 = 94 % , Z = 23.40 ]; OSA is associated with chronic vascular inflammation [ OR = 1.70 , 95% CI (1.39, 2.07), P < 0.00001 , I 2 = 16 % , Z = 5.18 ]. Conclusion. The incidence of obstructive sleep apnea in patients with CHD was higher than that in non-CHD patients, and obstructive sleep apnea was a risk factor for CHD.

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Section: Resultsmentioning

confidence: 99%

Association of Obstructive Sleep Apnea Syndrome (OSA/OSAHS) with Coronary Atherosclerosis Risk: Systematic Review and Meta-Analysis

Chen

Zou

Wang

2022

Computational and Mathematical Methods in Medicine

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“…Conversely, the least effective treatment was NSO (21%). Twenty-two trials [7,9,10,14,16,17,20,29,[31][32][33][35][36][37][40][41][42][43][44][46][47][48] reported the results of the dDBP. The interventions included were CPAP (16 trials; 1203 participants), MADs (3 trials; 274 participants), MRAs (2 trials; 132 participants), RDN (1 trial; 60 participants), and NSO (1 trial; 301 participants) (Fig.…”

Section: Daytime Blood Pressurementioning

confidence: 99%

Effect of different treatments for obstructive sleep apnoea on blood pressure

Kou¹,

Zhao²,

Lin³

et al. 2022

Journal of Hypertension

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Objective: Obstructive sleep apnoea (OSA) is a common cause of secondary hypertension. This network metaanalysis (NMA) assessed the effect of different OSA treatments on lowering blood pressure.Methods: PubMed, EMBASE, Web of Science, and Cochrane Library databases were searched for relevant randomized controlled trials. The search strategies included the concepts of OSA, blood pressure, hypertension, and blood pressure-reducing treatments without language or data restriction (from inception to 1 June 2021). The outcomes included office SBP, office DBP, daytime SBP (dSBP) and DBP (dDBP), and night-time SBP (nSBP) and DBP (nDBP). A Bayesian network meta-analysis was performed, and mean differences with 95% credibility intervals were calculated.Results: We reviewed 49 randomized controlled trials involving 4893 patients and the following interventions: continuous positive-airway pressure (CPAP), mandibular advancement devices, nocturnal supplemental oxygen, surgery, b-blocker, angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs), renal sympathetic denervation (RDN), mineralocorticoid receptor antagonists (MRAs), calcium channel blockers. MRAs were significantly associated with blood pressure reduction followed by ACEI/ARB. RDN could reduce office SBP, office DBP, 24-h SBP, 24-h DBP, dSBP, and dDBP. CPAP also demonstrated modest blood pressure lowering. Conclusion:MRAs and ACEIs/ARBs can reduce blood pressure effectively in patients with OSA. RDN is a novel hypertension treatment that lowered blood pressure in such patients. CPAP was associated with mild but stable blood pressure reduction, and it might be helpful as an adjunctive therapy in OSA patients with hypertension.Review registration: This systematic review and metaanalysis was registered in PROSPERO: CRD42021240891.

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“…Several recent studies showed that short-term CPAP treatment can improve cardiac function and structure, however further studies are needed to confirm its theoretical benefit on stroke risk. (54)(55)(56)(57)(58)(59) Studies have reported an association between SBD and carotid atherosclerosis. Interestingly asymptomatic carotid stenosis is associated with central, but not obstructive apneas.…”

Section: Pathophysiologymentioning

confidence: 99%

Sleep and Stroke: New Updates on Epidemiology, Pathophysiology, Assessment, and Treatment

Lau

Rundek

Ramos

2019

Curr Sleep Medicine Rep

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Purpose of review-This review aims to discuss the most recent data on sleep disorders and stroke, highlighting relevant findings for the practicing neurologist or health providers who encounter patients with sleep disorders and stroke. Recent findings-Sleep apnea and abnormal sleep duration have the strongest association with stroke risk. Possible mechanisms include non-dipping of blood pressure during sleep, hypoxemia or reoxygenation leading to sympathetic activation, hypertension, atrial fibrillation and impaired cerebral hemodynamics. Treatment studies suggest that continuous positive airway pressure (CPAP) for sleep apnea could improve primary prevention of stroke, but data is equivocal for secondary prevention. However, CPAP could improve functional outcomes after stroke. Summary-Sleep disorders present an opportunity to improve stroke risk and functional outcomes. However, new strategies are needed to determine the patients at high-risk who would most likely benefit from targeted care. Novel methods for phenotyping sleep disorders could provide personalized stroke care to improve clinical outcomes and public health strategies.

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Cardiac structure and function improvements in coronary artery disease combined with severe obstructive sleep apnea/hypopnea syndrome patients via noninvasive positive pressure ventilation therapy

Abstract: For patients with coronary heart disease combined with OSAHS, noninvasive mechanical ventilation therapy can significantly improve heart functions and reduce the occurrence of cardiovascular complications.

Cited by 14 publications

References 10 publications

Association of Obstructive Sleep Apnea Syndrome (OSA/OSAHS) with Coronary Atherosclerosis Risk: Systematic Review and Meta-Analysis

Association of Obstructive Sleep Apnea Syndrome (OSA/OSAHS) with Coronary Atherosclerosis Risk: Systematic Review and Meta-Analysis

Effect of different treatments for obstructive sleep apnoea on blood pressure

Sleep and Stroke: New Updates on Epidemiology, Pathophysiology, Assessment, and Treatment

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