Cardiac Resynchronization Therapy:

Lilli, Alessio; Ricciardi, Giuseppe; Porciani, Maria Cristina; Perini, Alessandro Paoletti; Pieragnoli, Paolo; Musilli, Nicola; Colella, Andrea; Pace, Stefano Del; Michelucci, Antonio; Turreni, Federico; Sassara, Massimo; Achilli, Augusto; Barold, S. Serge; Padeletti, Luigi

doi:10.1111/j.1540-8159.2007.00870.x

Cited by 59 publications

(42 citation statements)

References 46 publications

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“…48,49 Similarly, women with defibrillators have fewer hospitalizations and more robust ventricular remodeling than men. [50][51][52] It is unclear why, despite having a biological advantage, women do worse in the population of OHCAs. Factors such as earlier termination of resuscitative efforts, a higher number of rearrests due to more comorbidities, or older age at time of cardiac arrest could be playing a role in women.…”

Section: Discussionmentioning

confidence: 99%

Differential Survival for Men and Women from Out-of-hospital Cardiac Arrest Varies by Age: Results from the OPALS Study

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Differential Survival for Men and Women from Out-of-hospital Cardiac Arrest Varies by Age: Results from the OPALS Study

et al. 2014

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“…51,52,54 At variance with ICD studies, subgroup analyses of CRT trials suggest that women may have a better response to CRT, although different studies showed conflicting results. [55][56][57] In a post hoc analysis of the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) trial, Woo et al reported significant differences in outcome based on gender, with women randomised to CRT having a significantly lower incidence of the combined endpoint of first heart failure hospitalisation or death compared with women allocated to the placebo arm. On the other hand, no difference was reported among men for the same endpoint.…”

Section: Cardiac Resynchronisation Therapymentioning

confidence: 99%

Outcomes in Women Undergoing Electrophysiological Procedures

Biase

Basile

Al‐Ahmad

2013

Arrhythmia &Amp; Electrophysiology Review

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The number of invasive electrophysiological procedures is steadily increasing in Western countries, as the age of the population increases and technologies advance. In recent years, gender-related differences in cardiac rhythm disorders have been increasingly appreciated, which can potentially have a great impact on the outcomes of invasive electrophysiological procedures. Among supraventricular arrhythmias, women have a higher incidence of atrioventricular nodal re-entrant tachycardia and a significantly lower incidence of atrioventricular re-entrant tachycardia compared with males, and present to ablation procedures later and after having failed more antiarrhythmic drugs. The results of catheter ablation of atrial fibrillation in women have been reported worse than in men. This finding is possibly due to a later referral of females to ablation procedures, who present older and with a higher incidence of long-standing persistent atrial fibrillation. With regard to cardiac device implantation procedures, a smaller survival benefit from prophylactic implantable cardioverter defibrillator (ICD) implantation has been shown in women, essentially due to gender-specific differences in the clinical course of patients with severe left ventricular dysfunction, with women dying predominantly from non-arrhythmic causes. On the other side, the clinical outcome of cardiac resynchronisation therapy seems to be more favourable in women, who experience a greater degree of reverse left ventricular remodelling and a striking decrease of heart failure events or mortality after biventricular pacing. This review will summarise the available evidence on gender-related differences in outcomes of invasive electrophysiological procedures.

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“…37 In the Registry to Improve the Use of EvidenceBased Heart Failure Therapies in the Outpatient Setting (IMPROVE HF) trial, only 35% of indicated female patients initially had a CRT device, which improved to 65% with increased physician education at 24 months. 38 Arrhythmias in Pregnancy ECG changes in pregnancy include an increase in the resting heart rate by about 10 beats/minute, and a leftward shift of the electrical axis occurring secondary to enlargement of the gravid uterus.…”

Section: Sex Differences In Utilization and Response To Implantable Dmentioning

confidence: 99%

Arrhythmias in Women

Curtis

Narasimha

2012

Clinical Cardiology

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There are important gender differences in cardiac electrophysiology that affect the epidemiology, presentation, and prognosis of various arrhythmias. Women have been noted to have higher resting heart rates compared to men. They also have a longer QT interval, which puts them at an increased risk for drug-induced torsades de pointes. Women with atrial fibrillation are at a higher risk of stroke, and they are less likely to receive anticoagulation and ablation procedures compared to men. Women have a lower risk of sudden cardiac death and are less likely to have known coronary artery disease at the time of an event compared to men. Both men and women have been shown to derive an equal survival benefit from implantable cardioverter defibrillators and cardiac resynchronization therapy, although these devices are significantly underutilized in women. Women also appear to have a better response to cardiac resynchronization therapy in terms of reduced numbers of hospitalizations and more robust reverse ventricular remodeling. Further studies are required to elucidate the underlying pathophysiology of these sex differences in cardiac arrhythmias. IntroductionSex differences in cardiac electrophysiology affect the epidemiology, presentation, and prognosis of various arrhythmias. These sex differences can have important clinical and therapeutic implications. Although the exact reason for these differences is not known, the potential mechanisms include differences in cardiac size, structure, and the different ways in which hormones, drugs, and electrolytes affect cardiac ion channels in men and women. The purpose of this review is to provide a synopsis of the important gender differences with respect to arrhythmias and to summarize updates from recent studies.

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Cardiac Resynchronization Therapy:

Abstract: CRT induced a gender specific LV remodeling response.

Cited by 59 publications

References 46 publications

Differential Survival for Men and Women from Out-of-hospital Cardiac Arrest Varies by Age: Results from the OPALS Study

Differential Survival for Men and Women from Out-of-hospital Cardiac Arrest Varies by Age: Results from the OPALS Study

Outcomes in Women Undergoing Electrophysiological Procedures

Arrhythmias in Women

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