Cardiac Paraganglioma Presenting With Acute Myocardial Infarction and Stroke

Hayek, Emil; Hughes, Michael; Speakman, Eric; Miller, Hugh J.; Stocker, Patrick J.

doi:10.1016/j.athoracsur.2006.12.023

Cited by 25 publications

(14 citation statements)

References 7 publications

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“…In cases of extension to valves, other primary cardiac tumors such as mixoma or angiosarcoma must be excluded. More unusual presentations have been reported such as acute myocardial infarction and stroke [17], although in some cases, the tumor can be an incidental finding. A curious feature of the tumor in our patient was the absence of symptoms despite to be a functioning paraganglioma.…”

Section: Discussionmentioning

confidence: 99%

Surgical excision with left atrial reconstruction of a primary functioning retrocardiac paraganglioma

López

González

García

et al. 2013

J Cardiothorac Surg

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About 2% of all paragangliomas are located in the chest, and a few have been described to be found in the heart. Primary cardiac paragangliomas are extremely uncommon tumors and surgical experience with this neoplasm is limited. Treatment strategies described in the literature have included simple excision, excision with reconstruction, autotransplantation after excision of the tumor and even orthotopic cardiac transplantation, depending on the extent of disease. A primary retrocardiac paraganglioma catecholamine-productive was identified in an asymptomatic 49–year old female associated to familial pheochromocytoma-paraganglioma syndrome caused by germline mutation of the gen which codifies for the subunit B of succinate dehydrogenase enzyme (SDHB). The neoplasm was surgically excised from the posterior surface of the left atrium via median sternotomy using cardiopulmonary bypass. Direct ligation of feeding vessels of the tumor along with left atrial reinforcement using a pericardial patch was performed. The post-operative course was uneventful, with normalization of catecholamine secretion and no recurrence at three-month follow-up. We review the current literature about this exceptional cardiac tumor, pathophysiological conditions and options for surgical management.

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Section: Discussionmentioning

confidence: 99%

Surgical excision with left atrial reconstruction of a primary functioning retrocardiac paraganglioma

López

González

García

et al. 2013

J Cardiothorac Surg

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“…Clinical suspicion is raised in cases of resistant hypertension particularly in patients with a family history of phaeochromocytoma. However, more unusual presentations have been reported such as acute myocardial infarction and stroke [3], congestive heart failure [4], hypertensive crisis in labour [5] and upper limb parasthesia [6]. A family history of phaeochromocytoma may indicate MEN2, Von Hippel-Lindau syndrome, neurofibromatosis type 1 and familial phaeochromocytoma-paraganglioma syndrome [7], the latter being the most likely in this case as no features of the other syndromes were present.…”

Section: Discussionmentioning

confidence: 89%

“…There are only four previous cases of primary paraganglioma arising from the right atrium in the world literature [2,3,9]. All of these cases involved functional tumours with three presenting with persistent hypertension preoperatively and one case demonstrating intraoperative hypertensive crisis on palpation of the tumour [10].…”

Section: Discussionmentioning

confidence: 97%

Right atrial paraganglioma: an unusual primary cardiac tumour

Kennelly

Aziz

Toner

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…2 The commonly involved sites are the roof of the left atrium, the interatrial septum, and the anterior surface of the heart; involvement of the right atrium and left ventricle is reportedly rare. [3][4][5] Clinical symptoms of catecholamine excess, such as hypertension, palpitations, headaches, sweating, and weight loss, occur in approximately 50% of patients with a cardiac paraganglioma. Acute myocardial infarction, cerebral infarction, atypical chest pain, heart failure, and various other symptoms of tumor infiltration and compression are also seen.…”

Section: Discussionmentioning

confidence: 99%