Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats

Zhu, Minghua; Zhao, Jinping; Cui, Ning; Gonçalves-Rizzi, Victor Hugo; Possomato-Vieira, José Sérgio; Nascimento, Regina Aparecida; Dias‐Junior, Carlos A.

doi:10.1007/s11596-017-1825-6

Cited by 2 publications

(2 citation statements)

References 37 publications

(70 reference statements)

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“…Furthermore, in a study aimed at understanding the effects of MPO in hypertensive pregnancy, researchers observed increased cardiac MPO in the left but not right ventricle of hypertensive pregnant rats (131). Increased circulating MPO activities were associated with concomitantly lower number of viable fetuses, litter size, fetal and placenta weights, as well as decreases in nitric oxide in hypertensive rats.…”

Section: Hypertensionmentioning

confidence: 99%

Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection

Ramachandra

Chua

et al. 2020

Antioxidants & Redox Signaling

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Significance: Myeloperoxidase (MPO) is a heme peroxidase that is primarily expressed by neutrophils. It has the capacity to generate several reactive species, essential for its inherent antimicrobial activity and innate host defense. Dysregulated MPO release, however, can lead to tissue damage, as seen in several diseases. Increased MPO levels in circulation are therefore widely associated with conditions of increased oxidative stress and inflammation. Recent Advances: Several studies have shown a strong correlation between MPO and cardiovascular disease (CVD), through which elevated levels of circulating MPO are linked to poor prognosis with increased risk of CVD-related mortality. Accordingly, circulating MPO is considered a ''high-risk'' biomarker for patients with acute coronary syndrome, atherosclerosis, heart failure, hypertension, and stroke, thereby implicating MPO as a multifaceted target for cardiovascular protection. Consistently, recent studies that target MPO in animal models of CVD have demonstrated favorable outcomes with regard to disease progression. Critical Issues: Although most of these studies have established a critical link between circulating MPO and worsening cardiac outcomes, the mechanisms by which MPO exerts its detrimental effects in CVD remain unclear. Future Directions: Elucidating the mechanisms by which elevated MPO leads to poor prognosis and, conversely, investigating the beneficial effects of therapeutic MPO inhibition on alleviating disease phenotype will facilitate future MPO-targeted clinical trials for improving CVD-related outcomes. Antioxid. Redox Signal.

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Section: Hypertensionmentioning

confidence: 99%

Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection

Ramachandra

Chua

et al. 2020

Antioxidants & Redox Signaling

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“…Neutrophils and monocytes normally produce and release myeloperoxidase (MPO) [ 11 ]. Elevated level of MPO reflects the degree of neutrophil activation and it has been associated with vascular dysfunction [ 12 ]. Additionally, MPO is involved in the formation of ROS and the oxidation of biological material [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

Grujić-Milanović

Jacević

Miloradović

et al. 2021

IJMS

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Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.

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Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats

Cited by 2 publications

References 37 publications

Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection

Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection

Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

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