Cardiac metabolic imaging: current imaging modalities and future perspectives

Weijer, Tineke van de; Paiman, Elisabeth H.M.; Lamb, Hildo J.

doi:10.1152/japplphysiol.01051.2016

Cited by 9 publications

(6 citation statements)

References 98 publications

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“…In the normal myocardium, ATP synthesis can be maintained at the rate of ATP demand, and PCr levels are sustained. However, in cardiac disease with a decreased mitochondrial function, ATP demand may outweigh the mitochondrial capacity for ATP production, and hence, PCr concentrations will fall [ 72 ]. Hence, the PCr/ATP ratio has been suggested to be a marker of mitochondrial function; however, one should be aware that creatine supply, pH, and oxygen supply may independently influence PCr concentrations in the cardiomyocyte [ 73 ].…”

Section: Mitochondrial Functionmentioning

confidence: 99%

Changes in Cardiac Metabolism in Prediabetes

Wit‐Verheggen

Weijer

2021

Biomolecules

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In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD risk factors. Diastolic dysfunction is one of the early changes in cardiac function that precedes the onset of cardiac failure, and it occurs already in the prediabetic state. It is clear that these changes are closely linked to alterations in cardiac metabolism; however, the exact etiology is unknown. In this narrative review, we provide an overview of the early cardiac changes in fatty acid and glucose metabolism in prediabetes and its consequences on cardiac function. A better understanding of the relationship between metabolism, mitochondrial function, and cardiac function will lead to insights into the etiology of the declined cardiac function in prediabetes.

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Section: Mitochondrial Functionmentioning

confidence: 99%

Changes in Cardiac Metabolism in Prediabetes

Wit‐Verheggen

Weijer

2021

Biomolecules

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“…With technological advancements over the past few decades, many biomedical imaging tools are available to noninvasively study different aspects of cardiac pathophysiology and function in animal models and humans (please see recent reviews on this topic 1,2 and the references cited therein). Of these, techniques based on MRS or MRSI and PET are the most relevant modalities for cardiometabolic imaging.…”

Section: Introductionmentioning

confidence: 99%

Quantitative ¹⁷O MRSI of myocardial oxygen metabolic rate, blood flow, and oxygen extraction fraction under normal and high workload conditions

Zhu,

Chen

2023

Magnetic Resonance in Med

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PurposeThe heart is a highly aerobic organ consuming most of the oxygen the body in supporting heart function. Quantitative imaging of myocardial oxygen metabolism and perfusion is essential for studying cardiac physiopathology in vivo. Here, we report a new imaging method that can simultaneously assess myocardial oxygen metabolism and blood flow in the rat heart.MethodsThis novel method is based on the 17O‐MRSI combined with brief inhalation of 17O‐isotope labeled oxygen gas for quantitative imaging of myocardial metabolic rate of oxygen consumption (MVO2), myocardial blood flow (MBF), and oxygen extraction fraction (OEF). We demonstrate this imaging method under basal and high workload conditions in rat hearts at 9.4 T.ResultsWe show that this 17O MRSI–based approach can directly measure and image MVO2 (1.35–4.06 μmol/g/min), MBF (0.49–1.38 mL/g/min), and OEF (0.33–0.44) in the heart of anesthetized rat under basal and high workload (21.6 × 103–56.7 × 103 mmHg • bpm) conditions. Under high workload condition, MVO2 and MBF values in healthy rats approximately doubled, whereas OEF remained unchanged, indicating a strong coupling between myocardial oxygen metabolic demand and supply through blood perfusion.ConclusionThe 17O‐MRSI method has been used to simultaneously image the myocardial metabolic rate of oxygen consumption, blood flow, and oxygen extraction fraction in small animal hearts, which are sensitive to the physiological changes induced by high workload. This approach could provide comprehensive measures that are critical for studying myocardial function in normal and diseased states and has a potential for translation.

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“…[1][2][3][4] Non-invasive imaging of cardiac LCFA metabolism is crucial for the evaluation of cardiac function, which leads to the understanding of heart conditions in health and disease. [5][6][7] As non-invasive cardiac metabolism imaging modalities, single-photon emission computed tomography (SPECT) and positron emission tomography (PET) with radioactive LCFA analogues such as β-methyl [ 123 I] iodophenyl-pentanedecanoic acid ( 123 I-BMIPP) have been widely used in clinical studies. [8][9][10][11][12][13][14][15][16] Although SPECT and PET enable highly sensitive metabolic imaging, these imaging modalities have several disadvantages such as the high cost of instruments and radioactive tracer synthesis.…”

Section: Introductionmentioning

confidence: 99%