Quantitative 17O MRSI of myocardial oxygen metabolic rate, blood flow, and oxygen extraction fraction under normal and high workload conditions
Xiao‐Hong Zhu,
Wei Chen
Abstract:PurposeThe heart is a highly aerobic organ consuming most of the oxygen the body in supporting heart function. Quantitative imaging of myocardial oxygen metabolism and perfusion is essential for studying cardiac physiopathology in vivo. Here, we report a new imaging method that can simultaneously assess myocardial oxygen metabolism and blood flow in the rat heart.MethodsThis novel method is based on the 17O‐MRSI combined with brief inhalation of 17O‐isotope labeled oxygen gas for quantitative imaging of myocar… Show more
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