Cardiac manifestations in Behcet&amp;apos;s disease

Demirelli, Selami; Değirmenci, Hüsnü; İnci, Sinan; Arif, Ambreen

doi:10.5582/irdr.2015.01007

Cited by 111 publications

(91 citation statements)

References 44 publications

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“…Cardiac involvement is relatively uncommon [97]. The heart and great vessels are not primary targets of BD, but although not well recognized, arterial or cardiac involvement are life-threatening with associated strong prognostic implications in BD [3]. Cardiac involvement is one of the most severe complications in patients with BD despite its sporadic occurrence, being greatly correlated with mortality [98].…”

Section: Introductionmentioning

confidence: 99%

“…Mechanisms of atherothrombogenesis have been associated with inflammation and immune disorders [2]. In the recent past, many authors began to classify BD as an autoinflammatory disease rather than an autoimmune disease [3].…”

Section: Pathogenesismentioning

confidence: 99%

“…Cardiac involvement is one of the prognostically devastating manifestations of Behçet's disease (BD). Cardiac involvement is relatively uncommon [3]. The heart and great vessels are not primary targets of BD, but although not well recognized, arterial or cardiac involvement is life-threatening with associated strong prognostic implications in BD.…”

mentioning

confidence: 99%

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Vascular Manifestations of Behçet’s Disease

Demïrtürk¹,

Tünel²,

Alemdaroğlu³

2017

Behcet's Disease

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Behçet's disease (BD), a very morphologically diverse systemic disease, may involve the vascular system. The venous system is the most frequently attacked vessel system.The arterial system, when involved, increases the severity and morbidity of Behçet's disease. Cardiac involvement, although rare, can be very subtle and in itself increases the mortality. Vasculitis is the hallmark pathology resulting in occlusion, aneurysms, or both.Vascular involvement may be very challenging in all phases of treatment beginning from diagnosis till recovery and remission.

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Section: Introductionmentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

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Vascular Manifestations of Behçet’s Disease

Demïrtürk¹,

Tünel²,

Alemdaroğlu³

2017

Behcet's Disease

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“…Furthermore, CM in BD could be ischemic, non-ischemic, or inflammatory. It could manifest as systolic or diastolic heart failure, or even as asymptomatic systolic or diastolic dysfunction [10]. The clinical presentation of CM in BD could include fever, dyspnea, chest pain, hemoptysis, and edema [11].…”

Section: Introductionmentioning

confidence: 99%

Dilated Cardiomyopathy in Behcet′s Disease in a Young Male Patient

Khederlou

Taheri

Sadeghi

et al. 2017

ijcp

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Behcet's disease is a multi-systemic, inflammatory, and chronic disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and other systemic organ involvement. Cardiac involvement in Behcet's disease is rare; however, it plays an important role in prognosis and increases mortality. The current researchers hereby have reported a case of Behcet′s disease with dilated cardiomyopathy. A 28-year-old male patient was presented with constitutional symptoms, oral and genital aphthous ulcers, pseudofolliculitis, tachycardia, arthritis, splenomegaly, erythrocyte sedimentation rate and C-reactive protein elevation, and left ventricular systolic dysfunction with left ventricular ejection fraction of 45%. Azathioprine and prednisolone were begun for the patient.

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“…Cardiac complications such as (post) inflammatory occlusion of coronary arteries due to either vasculitis or coagulation disorders [4], and heart failure as a result of either inflammation of the aortic valves or the right ventricle have been observed in BD patients [5]. Despite the fact that no unambiguous relationship between heart failure and BD has been established [2], other cardiovascular complications including pericarditis, conduction disturbances, myocardial lesions, and valvular disease [6,7] have been described in BD patients. However, although inflammatory vascular disorders are related with cardiovascular complications, remarkably little cardiovascular comorbidity is reported in BD.…”

Section: Introductionmentioning

confidence: 99%

Patients with Behcet’s Disease and Cardiovascular Risk Factors are at Risk for Early Cardiovascular and Renal Disease

Hcvd¹,

Tbvd²,

Jh³

et al. 2017

J Clin Case Rep

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We present a case of a 39-year-old Turkish female patient with a mild clinical phenotype of Behçet's disease (BD), but experiencing severe cardiac and renal disease, probably enhanced by microvascular atherosclerosis and hypertension. In this case, several cardiovascular risk factors like positive family history, hypertension and smoking were present. Up until recently cardiovascular risk factors were relatively neglected in BD, however recent reports suggest that traditional risk factors are an independent predictor of early coronary artery disease-related morbidity in young BD patients. With this case report we want to stress the fact that severe atherosclerotic complications occur even in young BD patients with longstanding stable, mild disease. This is probably due to chronic inflammation process in chronic diseases like BD, which is a known factor in the initiation and progression of the atherosclerotic process. Therefore, a tight, careful risk factor management should be implied during the follow-up of BD patients.

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Cardiac manifestations in Behcet's disease

Cited by 111 publications

References 44 publications

Vascular Manifestations of Behçet’s Disease

Vascular Manifestations of Behçet’s Disease

Dilated Cardiomyopathy in Behcet′s Disease in a Young Male Patient

Patients with Behcet’s Disease and Cardiovascular Risk Factors are at Risk for Early Cardiovascular and Renal Disease

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