Cardiac magnetic resonance evaluation of left ventricular functional, morphological, and structural features in children and adolescents vs. young adults with isolated left ventricular non-compaction

Cardiovascular magnetic resonance based diagnosis of left ventricular non-compaction cardiomyopathy: impact of cine bSSFP strain analysis

“…To the best of the authors' knowledge, this study represents the largest group of LVNC phenotype patients assessed by CMR FT strain analysis. The findings of impaired myocardial strain among LVNC phenotype patients are consistent with previous smaller studies [26,27]. A study by Cai J et al investigated the relationship between LV hypertrabeculation measured by fractal analysis and myocardial deformation by CMR FT among 180 healthy subjects and 10 LVNC patients, demonstrating an independent association between the degree of hypertrabeculation and reduced circumferential strain [26].…”

“…A study by Cai J et al investigated the relationship between LV hypertrabeculation measured by fractal analysis and myocardial deformation by CMR FT among 180 healthy subjects and 10 LVNC patients, demonstrating an independent association between the degree of hypertrabeculation and reduced circumferential strain [26]. A retrospective study by Nucifora et al demonstrated impairment of radial, circumferential and longitudinal strain assessed by CMR FT in separate groups of children/adolescents and young adults with a total of 32 isolated LVNC patients compared to age-matched controls [27]. Impairment of myocardial deformation in the children/adolescent group with preserved LVEF but comparable degrees of non-compaction to young adult patients with reduced LVEF was observed, suggesting that abnormal strain may predict the development of clinically overt cardiomyopathy in LVNC.…”

Prognostic value of myocardial deformation imaging by cardiac magnetic resonance feature-tracking in patients with a first ST-segment elevation myocardial infarction

“…[4] Among these techniques, CMR feature-tracking has gained prominence as a fast and accurate modality for the assessment of LV strain using the basic cine CMR sequences without any need for a specific encoding pulse and its utility has been demonstrated in a number of cardiac states. [5][6][7][8][9][10] However, Scarce data are available whether CMR assessment of myocardial strain provides independent and incremental prognostic information in STEMI patients. The aim of the present study was to investigate the prognostic utility of CMR feature-tracking derived LV global circumferential strain (GCS) in patients admitted with a first STEMI and treated with primary percutaneous coronary intervention (PCI).…”

Left Ventricular Non-Compaction Cardiomyopathy

“…Underestimation of LVNC occurs when the regions of the mid-ventricular and apical segments are not properly visible during echocardiography. Cardiac MRI provides an opportunity to identify LVNC more precisely because of its excellent resolution at any plane of imaging [1,2,6,7,16]. MRI-criteria of LVNC (ratio of non-compacted to compacted ration >2.3) as proposed by Peterson in 2005 allows to distinguishe "pathological non-compaction, with values for sensitivity, specifi city, positive and negative predictions of 86%, 99%, 75%, and 99%, respectively" [20].…”

“…Cardiac MRI is a method of confi rming LVNC diagnosis in patients, when echocardiographic criteria remain doubtful, and allows identifying cardiac fi brosis in patients with LVNC during late gadolinium enhancement (Figs. 1, 2) [16,26]. Nucifora et al found, that the presence and extent of myocardial fi brosis along withLV dysfunction are related to adverse clinical events [16].…”