Left Ventricular Non-Compaction Cardiomyopathy

Oryshchyn, Nelya; Ivaniv, Yuriy

doi:10.25040/ntsh2019.01.07

Cited by 3 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CMR imaging helps identify LVNC more precisely. CMR criteria by Peterson with sensitivity of 86% and specificity of 99% include assessment of the noncompacted to compacted ratio, which has to be more than 2.3 during the diastole in any long-axis LV image to make a diagnosis of LVNC [ 12 ]. Jacquier et al proposed to use a highly sensitive and specific criterion: a trabeculated left ventricular mass should be more than 20% of the total LV mass [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Left Ventricular Noncompaction Cardiomyopathy in an Elderly Patient: A Case Report and Literature Review

Okan¹,

Lodeen²,

Abawkaw³

et al. 2023

Cureus

View full text Add to dashboard Cite

Isolated left ventricular noncompaction cardiomyopathy (LVNC), also known as spongy myocardium, is an extremely rare congenital disorder belonging to unclassified cardiomyopathies by the World Health Organization and classified as a genetic cardiomyopathy by the American Heart Association. Adult prevalence is 0.017-0.26% in observational echocardiographic studies. The disease occurs due to the intrauterine arrest of normal myocardial compaction, leading to left ventricular dysfunction. Reported mortality is high, ranging from 35 to 47% over a 42- to 72-month follow-up period. Knowledge regarding proper diagnosis, morbidity, and prognosis is limited; thus, this disease is subdiagnosed. Our aim is to highlight a diagnostic approach to LVNC in an elderly patient and to stress specific diagnostic signs that make the disease more recognizable. We are reporting a case of noncompaction cardiomyopathy in a 62-year-old male without any significant past medical history who was referred to our clinic for arrhythmia evaluation. The patient had several brief episodes of palpitations over the past two months. On physical examination, he presented a blowing systolic murmur at the apex and an irregularly irregular rhythm. The 12-lead electrocardiogram (ECG) demonstrated atrial fibrillation and ST-T segment depression in the V4-V6 leads. A transthoracic echocardiogram (TTE) showed signs of dilated cardiomyopathy, severe eccentric left ventricular hypertrophy, decreased contractility with an ejection fraction (EF) <30%, moderate mitral and tricuspid regurgitations, and moderate pulmonary hypertension. Multiple prominent trabeculations were noticed in the middle and apical segments of the left ventricle. The noncompacted to compacted myocardium ratio was >2.5:1. Cardiac catheterization excluded ischemic heart disease. Cardiac magnetic resonance (CMR) imaging confirmed the diagnosis of LVNC. The patient started treatment with carvedilol, ramipril, verospiron, torasemide, and rivaroxaban. An implantable cardioverter-defibrillator (ICD) was recommended. In conclusion, the diagnosis of LVNC in the adult population is often delayed because of similarities with more frequently diagnosed diseases. TTE is the initial diagnostic test of choice. Additional imaging modalities (contrast echocardiography, CMR) can help confirm the diagnosis. Early diagnosis is crucial because of the high incidence of life-threatening complications related to heart failure, thromboembolic events, and ventricular arrhythmias. Additional prospective studies are needed to improve the management and outcomes of this rare cardiomyopathy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Jacquier et al proposed to use a highly sensitive and specific criterion: a trabeculated left ventricular mass should be more than 20% of the total LV mass [ 13 ]. Cardiac magnetic resonance also identifies the extent of cardiac fibrosis using late gadolinium enhancement, which is related to adverse clinical events [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Noncompaction Cardiomyopathy in an Elderly Patient: A Case Report and Literature Review

Okan¹,

Lodeen²,

Abawkaw³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Cardiac MRI (CMRI) imaging aids in more accurate LVNC identification. Assessment of the non-compacted to compacted ratio is one of the CMR criteria by Peterson with a sensitivity of 86% and specificity of 99%, which must be greater than 2.3 during diastole in any long-axis LV image to make a diagnosis of LVNC [ 14 ]. A highly sensitive and precise criterion was suggested to be used by Jacquier et al [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Overlapping Phenotypes of Alcoholic Cardiomyopathy and Left Ventricular Non-compaction: A Case Report and Discussion of Converging Cardiomyopathies

Mendpara,

Endreddy,

Gajula

et al. 2023

Cureus

View full text Add to dashboard Cite

Left ventricular non-compaction cardiomyopathy, often known as LVNC, is a form of congenital cardiomyopathy that is extremely uncommon. It is a condition that may be identified by an elevated number of endomyocardial trabeculations as well as an increase in their prominence. Alcoholic cardiomyopathy, also known as ACM, is a non-ischemic form of dilated cardiomyopathy that is characterized by contractile failure and an enlargement of the heart ventricles. It is not entirely known whether or not there is a clinically significant overlap in phenotypic characteristics between the two illnesses. We report a patient who had previously been diagnosed with ACM and who had cardiac MRI results that fit the criteria for both LVNC and ACM.

show abstract